Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 23, 2026.

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3,605 clinical trials

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Preliminary Evaluation of [68Ga]CBP8 in Healthy Individuals, Lung Cancer, and Idiopathic Pulmonary Fibrosis Patients

for Pulmonary Fibrosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT03535545·Phase 1·Recruiting

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Angelman Syndrome Natural History Study

for Angelman Syndrome

8 locations incl. Los Angeles

Sponsor: Boston Children's Hospital

Sex: All·Age: All ages

Code: NCT04507997·Recruiting

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ABL001 + Dasatinib + Prednisone + Blinatumomab in BCR-ABL+ B-ALL or CML

for B-cell Acute Lymphoblastic Leukemia

4 locations incl. Chicago

Sponsor: Marlise Luskin, MD

Sex: All·Age: 18+

Code: NCT03595917·Phase 1·Recruiting

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Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells

for Neoplasms

100 locations incl. Birmingham

Sponsor: Celgene

Sex: All·Age: All ages

Code: NCT03435796·Phase 2, Phase 3·Recruiting

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Sleep-dependent Learning in Aging

for Sleep

1 location in Amherst

Sponsor: University of Massachusetts, Amherst

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT03840083·Recruiting

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A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration

for Age-Related Macular Degeneration

19 locations incl. Phoenix

Sponsor: Astellas Institute for Regenerative Medicine

Sex: All·Age: 50+

Code: NCT03178149·Phase 1·Recruiting

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Pharmacokinetics of Bivalirudin for Pediatric Anticoagulation

for Drug Effect

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: Up to 17

Code: NCT03532399·Recruiting

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Lung Recruitment Maneuver as a Potential Predictor of Fluid Responsiveness in Mechanically Ventilated Pediatric Patients

for Anesthesia

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: Up to 17

Code: NCT03431064·Recruiting

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Long-term Safety and Efficacy Follow-up of BIIB111 for the Treatment of Choroideremia and BIIB112 for the Treatment of X-Linked Retinitis Pigmentosa

for Choroideremia

10 locations incl. Los Angeles

Sponsor: NightstaRx Ltd, a Biogen Company

Sex: Male·Age: 18+

Code: NCT03584165·Phase 3·Enrolling By Invitation

Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers

for Recurrent Ovarian Cancer

Drug: Cemiplimab

11 locations incl. Birmingham

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT03564340·Phase 1, Phase 2·Recruiting

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Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

for Ganglioneuroblastoma

152 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 30

Code: NCT03126916·Phase 3·Recruiting

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Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone

for Giant Cell Tumor of Bone

14 locations incl. Los Angeles

Sponsor: St. Louis University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03295981·Phase 3·Recruiting

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A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

for Advanced/Metastatic Solid Tumors

23 locations incl. La Jolla

Sponsor: Merus B.V.

Sex: All·Age: 18+

Code: NCT03526835·Phase 1, Phase 2·Recruiting

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Longitudinal Early-onset Alzheimer's Disease Study Protocol

for Early Onset Alzheimer Disease

18 locations incl. Sun City

Sponsor: Indiana University

Sex: All·Age: 40 - 64·Accepts healthy volunteers

Code: NCT03507257·Recruiting

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Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change

for Advanced Lung Non-Small Cell Carcinoma

Drug: Osimertinib

345 locations incl. Anchorage

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03191149·Phase 2·Recruiting

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A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma

for Metastatic Castration Resistant Prostate Cancer (mCRPC)

Drug: Mevrometostat

46 locations incl. Tucson

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT03460977·Phase 1·Recruiting

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Patient Satisfaction With Appearance, Scar Outcome and Quality of Life After Skin Cancer Surgery

for Skin Cancer

5 locations incl. Sacramento

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 21+

Code: NCT03503240·Enrolling By Invitation

Brain Connectivity in Depression

for Depression

4 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT03276793·Recruiting

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A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

for Recurrent Glioblastoma Multiforme

5 locations incl. Boston

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT03423628·Phase 1·Recruiting

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Ivosidenib and Venetoclax With or Without Azacitidine in Treating Patients With IDH1 Mutated Hematologic Malignancies

for Acute Myeloid Leukemia

Drug: Venetoclax

4 locations incl. Boston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT03471260·Phase 1, Phase 2·Recruiting

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Service and Health Among Deployed Veterans

for Pulmonary Function

6 locations incl. San Diego

Sponsor: VA Office of Research and Development

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT02825654·Enrolling By Invitation

The PREDICT Registry:

for DCIS

30 locations incl. Scottsdale

Sponsor: PreludeDx

Sex: Female·Age: 30 - 85

Code: NCT03448926·Recruiting

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Phase I/II Trial of Lentiviral Gene Transfer for SCID-X1 With Low Dose Targeted Busulfan Conditioning

for Severe Combined Immunodeficiency, X Linked

4 locations incl. Los Angeles

Sponsor: David Williams

Sex: Male·Age: 0 - 5

Code: NCT03311503·Phase 1, Phase 2·Recruiting

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Gastroschisis Outcomes of Delivery (GOOD) Study

for Gastroschisis

38 locations incl. Phoenix

Sponsor: Medical College of Wisconsin

Sex: Female·Age: 18+

Code: NCT02774746·Recruiting

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Comparing Hypothermic Temperatures During Hemiarch Surgery

for Thoracic Aortic Disease

3 locations incl. Boston

Sponsor: Ottawa Heart Institute Research Corporation

Sex: All·Age: 18+

Code: NCT02860364·Recruiting

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Brain Effects of Gamma Frequency Sensory Stimulation (40Hz Light, Sound and Other Devices)

for Cognitively Healthy People

1 location in Cambridge

Sponsor: Massachusetts Institute of Technology

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT07496918·Phase 2·Recruiting

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LMWH vs Aspirin for VTE Prophylaxis in Orthopaedic Oncology

for Sarcoma

10 locations incl. Los Angeles

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03244020·Phase 4·Enrolling By Invitation

Home Hospital for Suddenly Ill Adults

for Infection

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT03524222·Recruiting

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BezafibrateTreatment for Bipolar Depression: A Proof of Concept Study

for Bipolar Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT02481245·Phase 2·Recruiting

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Randomization of Single vs Multiple Arterial Grafts

for Coronary Artery Disease

11 locations incl. Boulder

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18 - 70

Code: NCT03217006·Recruiting

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Responses to Genetic Risk Modifier Testing Among Women With Pathogenic Variants in Breast Cancer Predisposition Genes

for Genetic Testing

7 locations incl. Boston

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: Female·Age: 25+

Code: NCT03396341·Recruiting

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Genetics of Differences of Sex Development and Hypospadias

for Disorders of Sex Development

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: All ages

Code: NCT03102554·Enrolling By Invitation

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

for Functional Mitral Regurgitation

75 locations incl. Gilbert

Sponsor: Cardiac Dimensions, Inc.

Sex: All·Age: 18+

Code: NCT03142152·Recruiting

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SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

for Cancer, Metastatic

67 locations incl. Birmingham

Sponsor: Massive Bio, Inc.

Sex: All·Age: All ages

Code: NCT03452774·Recruiting

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Real-world Experience of Catheter Ablation for the Treatment of Paroxysmal and Persistent Atrial Fibrillation

for Paroxysmal Atrial Fibrillation

64 locations incl. Birmingham

Sponsor: Heart Rhythm Clinical and Research Solutions, LLC

Sex: All·Age: 18+

Code: NCT04088071·Recruiting

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A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy

for Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD)

Drug: Rituximab

40 locations incl. Duarte

Sponsor: Pierre Fabre Medicament

Sex: All·Age: All ages

Code: NCT03394365·Phase 3·Recruiting

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CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)

for Relapsed Hematologic Malignancy

Drug: Emavusertib

27 locations incl. Phoenix

Sponsor: Curis, Inc.

Sex: All·Age: 18+

Code: NCT03328078·Phase 1, Phase 2·Recruiting

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Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett's Esophagus

for Barrett Esophagus

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03830801·Recruiting

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Cardiogenic Shock Working Group Registry

for Cardiogenic Shock

16 locations incl. Weston

Sponsor: Tufts Medical Center

Sex: All·Age: 18+

Code: NCT04682483·Recruiting

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Biomarker Profiling in Individuals at Risk for Prion Disease

for CJD (Creutzfeldt Jakob Disease)

1 location in Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT05124392·Recruiting

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