A Long-term Follow-up Study in Patients Who Received BEAM-101for Hemoglobinopathy17 locations incl. BirminghamSponsor: Beam Therapeutics Inc.Sex: All·Age: 14 - 37Code: NCT07373639·RecruitingApply to this trial
A Long-term, Post-marketing Safety Study of Palynziq in Patients With PKU (PALace)for Phenylketonuria (PKU)12 locations incl. AuroraSponsor: BioMarin PharmaceuticalSex: All·Age: All agesCode: NCT05813678·RecruitingApply to this trial
Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3for COPD18 locations incl. BirminghamSponsor: Apreo Health, Inc.Sex: All·Age: 40 - 84Code: NCT06891755·RecruitingApply to this trial
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)for Treatment Resistant Depression24 locations incl. BirminghamSponsor: Abbott Medical DevicesSex: All·Age: 22 - 70Code: NCT06423430·RecruitingApply to this trial
A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)for Epilepsy, Temporal Lobe17 locations incl. Little RockSponsor: Neurona TherapeuticsSex: All·Age: 18 - 75Code: NCT06422923·Phase 1, Phase 2·RecruitingApply to this trial
A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myelomafor Multiple Myeloma28 locations incl. Little RockSponsor: Janssen Research & Development, LLCSex: All·Age: 18+Code: NCT07258511·Phase 3·RecruitingApply to this trial
A Study of Valemetostat Tosylate in Combination With DXd ADCs in Subjects With Solid Tumorsfor Advanced Solid Tumor20 locations incl. IrvineSponsor: Daiichi SankyoSex: All·Age: 18+Code: NCT06244485·Phase 1·RecruitingApply to this trial
Study of SGR-1505 in Mature B-Cell Neoplasmsfor Mature B-Cell Neoplasm16 locations incl. GilbertSponsor: Schrödinger, Inc.Sex: All·Age: 18+Code: NCT05544019·Phase 1·RecruitingApply to this trial
Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancerfor Ovarian Cancer21 locations incl. BirminghamSponsor: Regeneron PharmaceuticalsSex: Female·Age: 18+Code: NCT06787612·Phase 2·RecruitingApply to this trial
A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)for Relapsed or Refractory Multiple Myeloma (RRMM)22 locations incl. BirminghamSponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanySex: All·Age: 18+Code: NCT06615479·Phase 3·RecruitingApply to this trial
A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis, Progressive Forms of Multiple Sclerosis or Refractory Myasthenia Gravis (MG) (Breakfree-2)for Multiple Sclerosis17 locations incl. BirminghamSponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanySex: All·Age: 18 - 60Code: NCT06220201·Phase 1·RecruitingApply to this trial
A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancerfor Unresectable MelanomaDrug: IOV-400111 locations incl. Los AngelesSponsor: Iovance Biotherapeutics, Inc.Sex: All·Age: 18 - 70Code: NCT05361174·Phase 1, Phase 2·RecruitingApply to this trial
A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Kneefor Chondral Defect12 locations incl. Palo AltoSponsor: Vericel CorporationSex: All·Age: 10 - 17Code: NCT03588975·Phase 3·RecruitingApply to this trial
Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)for Non-Hodgkin Lymphoma18 locations incl. GilbertSponsor: Imugene LimitedSex: All·Age: 18+Code: NCT03666000·Phase 1·RecruitingApply to this trial
Study of INCA036978 in Participants With Myeloproliferative Neoplasmsfor Myeloproliferative NeoplasmsDrug: INCA03697822 locations incl. BirminghamSponsor: Incyte CorporationSex: All·Age: 18+Code: NCT07441694·Phase 1·RecruitingApply to this trial
Evaluating the Safety and Efficacy of dNerva Lung Denervation System in Patients With COPDfor COPD10 locations incl. BirminghamSponsor: Nuvaira, Inc.Sex: All·Age: 40 - 80Code: NCT07051707·RecruitingApply to this trial
A Study to Learn About the Effects of Felzartamab Infusions in Adults With Kidney Transplants Who Have Late Isolated Microvascular Inflammationfor Microvascular Inflammation20 locations incl. Loma LindaSponsor: BiogenSex: All·Age: 18 - 74Code: NCT07219043·Phase 2·RecruitingApply to this trial
A Study to Evaluate INCA035784 in Participants With Myeloproliferative Neoplasmsfor Myeloproliferative Neoplasms13 locations incl. PhoenixSponsor: Incyte CorporationSex: All·Age: 18+Code: NCT07008118·Phase 1·RecruitingApply to this trial
A Study of Navlimetostat (BMS-986504) in Participants With Pre-treated Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With Homozygous MTAP Deletion (MountainTAP-9)for Carcinoma, Non-Small-Cell LungDrug: Navlimetostat12 locations incl. AnchorageSponsor: Bristol-Myers SquibbSex: All·Age: 18+Code: NCT06855771·Phase 2·RecruitingApply to this trial
Phase 2 Study of Inhaled SNG001 in Mechanically Ventilated Patients With Respiratory Viral Infectionfor Viral Pneumonia22 locations incl. SacramentoSponsor: Synairgen Research Ltd.Sex: All·Age: 18+Code: NCT06999603·Phase 2·RecruitingApply to this trial
Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosisfor Multiple Sclerosis, Relapsing-Remitting12 locations incl. Loma LindaSponsor: Bristol-Myers SquibbSex: All·Age: 10 - 17Code: NCT06408259·Phase 3·RecruitingApply to this trial
A Study to Investigate Safety and Effectiveness of BGB-16673 in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignanciesfor B-cell Malignancy18 locations incl. PhoenixSponsor: BeOne MedicinesSex: All·Age: 18+Code: NCT06634589·Phase 1, Phase 2·RecruitingApply to this trial
XTX301 in Patients With Advanced Solid Tumorsfor Advanced Solid Tumor12 locations incl. SacramentoSponsor: Xilio Development, Inc.Sex: All·Age: 18+Code: NCT05684965·Phase 1, Phase 2·RecruitingApply to this trial
A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignanciesfor Chronic Lymphocytic Leukemia (CLL)18 locations incl. DuarteSponsor: Nurix Therapeutics, Inc.Sex: All·Age: 18+Code: NCT05131022·Phase 1·RecruitingApply to this trial
A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myelomafor Relapsed/Refractory Multiple MyelomaDrug: Daratumumab16 locations incl. BirminghamSponsor: BeOne MedicinesSex: All·Age: 18+Code: NCT04973605·Phase 1, Phase 2·RecruitingApply to this trial
A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With REGN5678 for Adult Participants With Advanced Prostate Cancerfor Metastatic Castration-resistant Prostate Cancer14 locations incl. Palo AltoSponsor: Regeneron PharmaceuticalsSex: Male·Age: 18+Code: NCT05125016·Phase 1, Phase 2·RecruitingApply to this trial
A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Diseasefor Autoimmune Diseases12 locations incl. OrangeSponsor: TScan Therapeutics, Inc.Sex: All·Age: 18+Code: NCT06587828·RecruitingApply to this trial
A Long-Term Study of Zasocitinib in Children and Teenagers With Plaque Psoriasisfor Plaque PsoriasisDrug: Zasocitinib11 locations incl. Chula VistaSponsor: TakedaSex: All·Age: 4 - 17Code: NCT07250802·Phase 3·RecruitingApply to this trial
Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemiafor Myelofibrosis22 locations incl. DuarteSponsor: Disc Medicine, IncSex: All·Age: 18+Code: NCT05320198·Phase 1, Phase 2·RecruitingApply to this trial
A Study of Valemetostat (DS-3201b) in Combination With Darolutamide in Metastatic Castration Resistant Prostate Cancer (mCRPC)for Metastatic Castration-resistant Prostate Cancer9 locations incl. La JollaSponsor: Daiichi SankyoSex: Male·Age: 18+Code: NCT07244341·Phase 1·RecruitingApply to this trial
A Study of DB-OTO, an Adeno-Associated Virus (AAV) Based Gene Therapy, in Children/Infants, Adolescents and Adults With Hearing Loss Due to Otoferlin Mutationsfor Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)9 locations incl. Los AngelesSponsor: Regeneron PharmaceuticalsSex: All·Age: All agesCode: NCT05788536·Phase 1, Phase 2·RecruitingApply to this trial
US National TOP Registryfor Lung Transplant7 locations incl. PhoenixSponsor: TransMedicsSex: All·Age: All agesCode: NCT06513091·RecruitingApply to this trial
GORE® TAG® Thoracic Branch Endoprosthesis Zone 0/1 Post-Approval Studyfor Aortic Arch Dissection10 locations incl. Los AngelesSponsor: W.L.Gore & AssociatesSex: All·Age: 18+Code: NCT07166133·RecruitingApply to this trial
A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab Deruxtecan (I-DXd) in Participants With Relapsed/Refractory Extensive-Stage Small Cell Lung Cancer (MK-6070-002)for Small Cell Lung CancerDrug: Gocatamig9 locations incl. AuroraSponsor: Merck Sharp & Dohme LLCSex: All·Age: 18+Code: NCT06780137·Phase 1, Phase 2·RecruitingApply to this trial
Aptis PRUJ Prosthesis for the Treatment of Patients With Proximal Radial Ulna Joint Disorders.for Arthritis7 locations incl. CarmelSponsor: Aptis MedicalSex: All·Age: 18 - 85·Accepts healthy volunteersCode: NCT05796908·RecruitingApply to this trial
Asciminib Roll-over Studyfor Chronic Myelogenous Leukemia6 locations incl. Ann ArborSponsor: Novartis PharmaceuticalsSex: All·Age: 7 - 100Code: NCT04877522·Phase 4·RecruitingApply to this trial
REMASTer: REcurrent Brain Metastases After SRS Trialfor Brain Metastases9 locations incl. Los AngelesSponsor: Monteris MedicalSex: All·Age: 18+Code: NCT05124912·RecruitingApply to this trial
A Study of BGB-11417 in Participants With Myeloid Malignanciesfor Acute Myeloid Leukemia5 locations incl. DuarteSponsor: BeOne MedicinesSex: All·Age: 18+Code: NCT04771130·Phase 1, Phase 2·RecruitingApply to this trial
Combination of TATE and PD-1 Inhibitor in Liver Cancerfor Hepatocellular Carcinoma3 locations incl. OrangeSponsor: Teclison Ltd.Sex: All·Age: 18 - 80Code: NCT03259867·Phase 2·RecruitingApply to this trial
GORE® ENFORM Biomaterial Product Studyfor Hernia, Ventral9 locations incl. San DiegoSponsor: W.L.Gore & AssociatesSex: All·Age: 18+Code: NCT04718168·RecruitingApply to this trial