SPI-1005 in Adults Receiving Cochlear Implantfor Hearing Loss6 locations incl. Iowa CitySponsor: Sound Pharmaceuticals, IncorporatedSex: All·Age: 18+Code: NCT06340633·Phase 2·RecruitingApply to this trial
A Study of BG-75098 Alone and in Combination With Other Agents in Adults With Advanced Solid Tumorsfor Advanced Solid Tumor6 locations incl. BirminghamSponsor: BeOne MedicinesSex: All·Age: 18+Code: NCT07226349·Phase 1·RecruitingApply to this trial
Evaluation of Potassium (K) and Ionized Calcium (iCa) Tests Using Capillary Specimensfor Hematologic Tests3 locations incl. AlbuquerqueSponsor: Abbott Point of CareSex: All·Age: 18+·Accepts healthy volunteersCode: NCT07287618·RecruitingApply to this trial
Evaluation of Neoadjuvant Xaluritamig in Localized Prostate Cancerfor Prostate Cancer7 locations incl. San FranciscoSponsor: AmgenSex: Male·Age: 18+Code: NCT06613100·Phase 1·RecruitingApply to this trial
Clinical Evaluation of Precision for the Potassium and Ionized Calcium Tests in Capillary Specimensfor Hematologic Tests3 locations incl. AlbuquerqueSponsor: Abbott Point of CareSex: All·Age: 18+·Accepts healthy volunteersCode: NCT07287631·RecruitingApply to this trial
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25for Breast Cancer1214 locations incl. BirminghamSponsor: NRG OncologySex: Female·Age: 18 - 60Code: NCT05879926·Phase 3·RecruitingApply to this trial
Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancerfor Previously Treated Non-Small Cell Lung Cancer1229 locations incl. BirminghamSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT03851445·Phase 2, Phase 3·RecruitingApply to this trial
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])for Lung Non-Small Cell Carcinoma1150 locations incl. AnchorageSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT04267848·Phase 3·RecruitingApply to this trial
ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumabfor Anatomic Stage I Breast Cancer AJCC v8667 locations incl. PhoenixSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT06876714·Phase 3·RecruitingApply to this trial
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Diseasefor Stage III Colon Cancer1023 locations incl. BirminghamSponsor: NRG OncologySex: All·Age: 18+Code: NCT05174169·Phase 2, Phase 3·RecruitingApply to this trial
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumabfor Anatomic Stage II Breast Cancer AJCC v8824 locations incl. BirminghamSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT05812807·Phase 3·RecruitingApply to this trial
Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomasfor Intracranial Meningioma780 locations incl. BirminghamSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT02523014·Phase 2·RecruitingApply to this trial
Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancerfor Fallopian Tube Endometrioid AdenocarcinomaDrug: Bevacizumab658 locations incl. BirminghamSponsor: NRG OncologySex: All·Age: 18+Code: NCT06580314·Phase 3·RecruitingApply to this trial
Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancerfor Advanced Lung Non-Squamous Non-Small Cell CarcinomaDrug: Bevacizumab603 locations incl. AnchorageSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT04181060·Phase 3·RecruitingApply to this trial
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)for Stage I Breast Cancer812 locations incl. BirminghamSponsor: NRG OncologySex: All·Age: 50 - 70Code: NCT04852887·Phase 3·RecruitingApply to this trial
Collection of Research Data and Samples From Patients Who Experience Immunotherapy Side Effectsfor Malignancy625 locations incl. AnchorageSponsor: Alliance for Clinical Trials in OncologySex: All·Age: All agesCode: NCT04242095·RecruitingApply to this trial
Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trialfor Extensive Stage Lung Small Cell CarcinomaDrug: Atezolizumab416 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT04402788·Phase 2, Phase 3·RecruitingApply to this trial
Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Studyfor Muscle Invasive Bladder Urothelial Carcinoma491 locations incl. PhoenixSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT05987241·Phase 2, Phase 3·RecruitingApply to this trial
Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)for Recurrent Lung Non-Small Cell Carcinoma454 locations incl. DaphneSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT05642572·Phase 2·RecruitingApply to this trial
Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancerfor Resectable Lung Non-Small Cell Carcinoma382 locations incl. BirminghamSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT06632327·Phase 3·RecruitingApply to this trial
Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancerfor Clear Cell Renal Cell Carcinoma415 locations incl. PhoenixSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT06661720·Phase 3·RecruitingApply to this trial
Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancerfor Anatomic Stage II Breast Cancer AJCC v8Drug: Durvalumab541 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT06058377·Phase 3·RecruitingApply to this trial
Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemiafor B Acute Lymphoblastic Leukemia455 locations incl. BirminghamSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18 - 39Code: NCT03150693·Phase 3·RecruitingApply to this trial
Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancerfor Locally Advanced Lung Non-Small Cell Carcinoma476 locations incl. BirminghamSponsor: NRG OncologySex: All·Age: 18+Code: NCT05624996·Phase 3·RecruitingApply to this trial
Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancerfor Locally Advanced Cervical Adenocarcinoma296 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: Female·Age: 18+Code: NCT07061977·Phase 3·RecruitingApply to this trial
A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancerfor Ovarian Carcinoma539 locations incl. BirminghamSponsor: NRG OncologySex: Female·Age: 35 - 50Code: NCT04251052·RecruitingApply to this trial
Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancerfor Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma321 locations incl. GilbertSponsor: NRG OncologySex: All·Age: 18+Code: NCT06958328·Phase 3·RecruitingApply to this trial
MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)for Acute Myeloid Leukemia336 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT05564390·Phase 2·RecruitingApply to this trial
Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphomafor Mantle Cell Lymphoma237 locations incl. Little RockSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 60+Code: NCT05976763·Phase 3·RecruitingApply to this trial
Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trialfor Metastatic Renal Cell Carcinoma323 locations incl. BirminghamSponsor: NRG OncologySex: All·Age: 18+Code: NCT05327686·Phase 2·RecruitingApply to this trial
Testing Whether High Dose Chemotherapy and Infusion of the Patients' Own Stem Cells Improves Survival in Patients With Peripheral T-cell Lymphoma Who Achieved a Complete Response at the End of the Initial Chemotherapyfor Anaplastic Large Cell Lymphoma, ALK-Negative158 locations incl. BirminghamSponsor: Eastern Cooperative Oncology GroupSex: All·Age: 18 - 75Code: NCT06724237·Phase 3·RecruitingApply to this trial
Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trialfor Metastatic Clear Cell Renal Cell Carcinoma387 locations incl. BirminghamSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT04510597·Phase 3·RecruitingApply to this trial
Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphomafor Classic Follicular LymphomaDrug: Mosunetuzumab270 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT06337318·Phase 3·RecruitingApply to this trial
BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Studyfor Clinical Stage III Cutaneous Melanoma AJCC v8Drug: Cabozantinib223 locations incl. PhoenixSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT05136196·Phase 2·RecruitingApply to this trial
High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancerfor Head and Neck Squamous Cell Carcinoma200 locations incl. GilbertSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT06992427·Phase 3·RecruitingApply to this trial
Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancerfor Oropharyngeal p16INK4a-Negative Squamous Cell CarcinomaDrug: Atezolizumab338 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT01810913·Phase 2, Phase 3·RecruitingApply to this trial
Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancerfor Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8153 locations incl. GilbertSponsor: NRG OncologySex: All·Age: 18+Code: NCT06532279·Phase 2·RecruitingApply to this trial
Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)for Myelodysplastic Syndrome141 locations incl. BerkeleySponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT06577441·Phase 2·RecruitingApply to this trial
Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)for Acute Myeloid LeukemiaDrug: Venetoclax225 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT06317649·Phase 2·RecruitingApply to this trial
Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)for Acute Myeloid Leukemia211 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18 - 59Code: NCT05554406·Phase 2·RecruitingApply to this trial