Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trialfor Castration-Sensitive Prostate CarcinomaDrug: Apalutamide195 locations incl. TucsonSponsor: Alliance for Clinical Trials in OncologySex: Male·Age: 18+Code: NCT06931340·Phase 3·RecruitingApply to this trial
Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancerfor Castration Levels of Testosterone334 locations incl. GilbertSponsor: SWOG Cancer Research NetworkSex: Male·Age: 18+Code: NCT03678025·Phase 3·RecruitingApply to this trial
Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, The ERASur Studyfor Metastatic Colorectal Adenocarcinoma185 locations incl. KingmanSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT05673148·Phase 3·RecruitingApply to this trial
Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)for Acute Myeloid LeukemiaDrug: Venetoclax167 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18 - 59Code: NCT05554393·Phase 2·RecruitingApply to this trial
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brainfor Anatomic Stage IV Breast Cancer AJCC v8262 locations incl. TucsonSponsor: NRG OncologySex: All·Age: 18+Code: NCT06500455·Phase 3·RecruitingApply to this trial
Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)for Acute Myeloid Leukemia129 locations incl. TucsonSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT06672146·Phase 2·RecruitingApply to this trial
Inotuzumab Ozogamicin and Blinatumomab With or Without Ponatinib in Treating Patients With Newly Diagnosed, Recurrent, or Refractory CD22-Positive B-Lineage Acute Lymphoblastic Leukemiafor B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative276 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT03739814·Phase 2·RecruitingApply to this trial
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancerfor Prostate Adenocarcinoma402 locations incl. BirminghamSponsor: NRG OncologySex: Male·Age: 18+Code: NCT05946213·Phase 3·RecruitingApply to this trial
Testing the Use of Ado-Trastuzumab Emtansine Compared to the Usual Treatment (Chemotherapy With Docetaxel Plus Trastuzumab) or Trastuzumab Deruxtecan for Recurrent, Metastatic, or Unresectable HER2-Expressing Salivary Gland Cancersfor Metastatic Salivary Gland Carcinoma152 locations incl. BirminghamSponsor: NRG OncologySex: All·Age: 18+Code: NCT05408845·Phase 2·RecruitingApply to this trial
Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trialfor Advanced Hepatocellular Carcinoma138 locations incl. BerkeleySponsor: NRG OncologySex: All·Age: 18+Code: NCT07166406·Phase 3·RecruitingApply to this trial
Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trialfor Metastatic Castration-Resistant Prostate Carcinoma102 locations incl. AnchorageSponsor: Alliance for Clinical Trials in OncologySex: Male·Age: 18+Code: NCT07200830·Phase 3·RecruitingApply to this trial
Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphomafor Diffuse Large B-Cell Lymphoma87 locations incl. TucsonSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT05633615·Phase 2·RecruitingApply to this trial
Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomasfor Metastatic Dedifferentiated Liposarcoma246 locations incl. PhoenixSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT06422806·Phase 3·RecruitingApply to this trial
Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Abilityfor Metastatic Lung Small Cell Carcinoma227 locations incl. PhoenixSponsor: NRG OncologySex: All·Age: 18+Code: NCT04804644·Phase 3·RecruitingApply to this trial
Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancerfor Astrocytoma, IDH-Mutant, Grade 3Drug: Vorasidenib82 locations incl. DuarteSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 12+Code: NCT07215910·Phase 3·RecruitingApply to this trial
Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgeryfor Grade 2 Meningioma198 locations incl. BirminghamSponsor: NRG OncologySex: All·Age: 18+Code: NCT03180268·Phase 3·RecruitingApply to this trial
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)for Hematologic Malignancies142 locations incl. BirminghamSponsor: Center for International Blood and Marrow Transplant ResearchSex: All·Age: All agesCode: NCT01351545·RecruitingApply to this trial
Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinomafor Recurrent Head and Neck Squamous Cell Carcinoma178 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18 - 79Code: NCT04671667·Phase 2·RecruitingApply to this trial
Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancerfor Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8100 locations incl. TucsonSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT07195734·Phase 2·RecruitingApply to this trial
Testing the Effectiveness of a Combination Targeted Therapy (ViPOR) for Patients With Relapsed and/or Refractory Aggressive B-cell Lymphomafor High Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements86 locations incl. TucsonSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT06649812·Phase 2·RecruitingApply to this trial
Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcomafor Retroperitoneal Sarcoma109 locations incl. BirminghamSponsor: European Organisation for Research and Treatment of Cancer - EORTCSex: All·Age: 18+Code: NCT04031677·Phase 3·RecruitingApply to this trial
Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone for People Who Have Newly Diagnosed AL Amyloidosisfor AL Amyloidosis117 locations incl. GoodyearSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT06022939·Phase 3·RecruitingApply to this trial
Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trialfor Castration-Resistant Prostate Carcinoma107 locations incl. BirminghamSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT06632977·Phase 2·RecruitingApply to this trial
Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adultsfor Cognitive Impairment, Mild102 locations incl. BirminghamSponsor: Duke UniversitySex: All·Age: 75+·Accepts healthy volunteersCode: NCT04262206·Phase 4·RecruitingApply to this trial
HEALEY ALS Platform Trial - Master Protocolfor Amyotrophic Lateral Sclerosis81 locations incl. PhoenixSponsor: Merit E. Cudkowicz, MDSex: All·Age: 18+Code: NCT04297683·Phase 2, Phase 3·RecruitingApply to this trial
Testing the Combination of Two Approved Drugs and One Experimental Drug in Patients With Relapsed or Refractory Multiple Myelomafor Recurrent Multiple Myeloma42 locations incl. AmesSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT06232044·Phase 1, Phase 2·RecruitingApply to this trial
Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanomafor Cutaneous Melanoma, Stage II130 locations incl. MobileSponsor: Melanoma and Skin Cancer Trials LimitedSex: All·Age: 18+Code: NCT03860883·RecruitingApply to this trial
Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapyfor Pulmonary Embolism40 locations incl. BirminghamSponsor: NYU Langone HealthSex: All·Age: 18+Code: NCT05591118·Phase 3·RecruitingApply to this trial
Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgeryfor Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v6 and v7140 locations incl. TucsonSponsor: ECOG-ACRIN Cancer Research GroupSex: All·Age: 18+Code: NCT03493425·Phase 2·RecruitingApply to this trial
IMPRoving Outcomes in Vascular DisEase - Aortic Dissectionfor Type B Aortic Dissection61 locations incl. BirminghamSponsor: Duke UniversitySex: All·Age: 21+Code: NCT06087029·RecruitingApply to this trial
Targeted Immunotherapy After Myeloablative TBI-Based Conditioning & AlloHCT in CAYA With High Risk T-Cell ALL & Lymphomafor T-cell Acute Lymphoblastic Leukemia16 locations incl. PhoenizSponsor: New York Medical CollegeSex: All·Age: Up to 39Code: NCT04972942·Phase 1·RecruitingApply to this trial
Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancerfor Buccal Mucosa Squamous Cell Carcinoma106 locations incl. BirminghamSponsor: NRG OncologySex: All·Age: 18+Code: NCT04333537·Phase 2, Phase 3·RecruitingApply to this trial
Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Networkfor Genetic Disease33 locations incl. BirminghamSponsor: National Human Genome Research Institute (NHGRI)Sex: All·Age: 1 Month - 100·Accepts healthy volunteersCode: NCT02450851·RecruitingApply to this trial
Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathyfor Peripartum Cardiomyopathy, Postpartum64 locations incl. BirminghamSponsor: Dennis M. McNamara, MD, MSSex: Female·Age: 18+Code: NCT05180773·Phase 4·RecruitingApply to this trial
Parkinson's Foundation PD GENEration Genetic Registryfor Parkinson's Disease54 locations incl. BirminghamSponsor: Parkinson's FoundationSex: All·Age: 18+Code: NCT04994015·RecruitingApply to this trial
Improving Safety and Quality of Tracheal Intubation Practice in Pediatric ICUsfor Failed or Difficult Intubation, Sequela63 locations incl. BirminghamSponsor: Children's Hospital of PhiladelphiaSex: All·Age: All agesCode: NCT02493478·RecruitingApply to this trial
Quality of Pediatric Resuscitation in a Multicenter Collaborativefor Cardiac Arrest40 locations incl. Los AngelesSponsor: Children's Hospital of PhiladelphiaSex: All·Age: 0 - 18Code: NCT02708134·RecruitingApply to this trial
Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavityfor Gastric Adenocarcinoma55 locations incl. IrvineSponsor: ECOG-ACRIN Cancer Research GroupSex: All·Age: 18+Code: NCT07001748·Phase 2, Phase 3·RecruitingApply to this trial
Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPERfor Endometrial Cancer72 locations incl. AnchorageSponsor: Canadian Cancer Trials GroupSex: Female·Age: 18+Code: NCT05640999·Phase 2·RecruitingApply to this trial
Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODSfor Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)32 locations incl. BirminghamSponsor: Nationwide Children's HospitalSex: All·Age: 1 Day - 17Code: NCT05267821·Phase 2, Phase 3·RecruitingApply to this trial