Paid Clinical Trials in Minnesota

Minnesota has 2,372 paid clinical trials enrolling now across cities including Rochester, Minneapolis and Saint Paul. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Minnesota include Mayo Clinic and University of Minnesota Medical Center, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 18, 2026.

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2,377 clinical trials

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Social Determinants of Health in Hepatobiliary Cancer Patients

for Malignant Hepatobiliary Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06053333·Recruiting

Apply to this trial

Tissue Destruction and Healing in Celiac Disease

for Celiac Disease

3 locations incl. Pasadena

Sponsor: University of Chicago

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT05680012·Recruiting

Apply to this trial

The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

for Atrial Fibrillation

93 locations incl. Phoenix

Sponsor: Johns Hopkins University

Sex: All·Age: 22 - 85

Code: NCT05836987·Phase 3·Recruiting

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Safety and Feasibility Study of the CELLSPAN Esophageal Implant (CEI) in Patients Requiring Short Segment Esophageal Replacement

for Esophageal Diseases

3 locations incl. Los Angeles

Sponsor: Harvard Apparatus Regenerative Technology, Inc.

Sex: All·Age: 18+

Code: NCT05877300·Phase 1·Recruiting

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Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

for Locally Advanced Lung Non-Small Cell Carcinoma

470 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05624996·Phase 3·Recruiting

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A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral Adrenoleukodystrophy

for Cerebral Adrenoleukodystrophy (cALD)

Drug: Leriglitazone

6 locations incl. Palo Alto

Sponsor: Minoryx Therapeutics, S.L.

Sex: Male·Age: 18+

Code: NCT05819866·Phase 3·Recruiting

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Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors

for Gastric Cancer

3 locations incl. Jacksonville

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06005493·Phase 1, Phase 2·Recruiting

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Evaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP)

for Familial Adenomatous Polyposis

17 locations incl. Scottsdale

Sponsor: Recursion Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT05552755·Phase 1, Phase 2·Recruiting

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Efficacy of Nerve Blocks for Episodic Migraine

for Episodic Migraine

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05734625·Phase 2·Recruiting

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A Study of Imaging in Demyelinating Diseases

for Multiple Sclerosis

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05805839·Phase 2·Enrolling By Invitation

Study of Enterra Programming with Nocturnal Cycling in Gastroparetics

for Gastroparesis

2 locations incl. Louisville

Sponsor: Enterra Medical, Inc.

Sex: All·Age: 18 - 70

Code: NCT05980455·Recruiting

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A Study of Wearable Device in Essential Tremor Patients

for Essential Tremor

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05976074·Enrolling By Invitation

Passive Leg Raise and Mini-fluid Challenge Effect on Various Cardiac Output Surrogates for Fluid Responsiveness

for Fluid Responsiveness

1 location in Saint Cloud

Sponsor: CentraCare

Sex: All·Age: 30 - 90

Code: NCT06390423·Recruiting

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The ED-AWARENESS-2 Trial

for Awareness

4 locations incl. Iowa City

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT05534243·Recruiting

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DCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid Tumors

for Advanced or Metastatic Solid Tumors

14 locations incl. Birmingham

Sponsor: DynamiCure Biotechnology

Sex: All·Age: 18+

Code: NCT05785754·Phase 1·Recruiting

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Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)

for Knee Pain Chronic

16 locations incl. Parker

Sponsor: Zimmer Biomet

Sex: All·Age: 18+

Code: NCT05787821·Recruiting

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The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)

for Coronary Artery Disease

6 locations incl. Los Angeles

Sponsor: Sunnybrook Health Sciences Centre

Sex: All·Age: 18+

Code: NCT05427370·Recruiting

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Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease

for Acute Myocardial Infarction

13 locations incl. Los Angeles

Sponsor: Population Health Research Institute

Sex: All·Age: 18+

Code: NCT05701358·Recruiting

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A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma

for Multiple Myeloma

Drug: Iberdomide

44 locations incl. Aurora

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT05827016·Phase 3·Recruiting

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Sleep-specific DBS Therapy in Parkinson's Disease

for Deep Brain Stimulation

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 21+

Code: NCT05962489·Recruiting

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Optimization of a Behavioral Intervention to Increase Physical Activity in Older Adults Living With HIV

for Hiv

2 locations incl. Minneapolis

Sponsor: Butler Hospital

Sex: All·Age: 50+

Code: NCT05752500·Recruiting

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A Clinical Trial to Investigate Long-term Safety, Tolerability, and Efficacy of Weekly Subcutaneous Doses With TransCon CNP in Children and Adolescents With Achondroplasia

for Achondroplasia

8 locations incl. Little Rock

Sponsor: Ascendis Pharma Growth Disorders A/S

Sex: All·Age: 3 - 15

Code: NCT05929807·Phase 2, Phase 3·Enrolling By Invitation

A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle

for Respiratory Function Loss

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05856136·Phase 4·Recruiting

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A Clinical Registry of Spontaneous Intracranial Hypotension

for Spontaneous Intracranial Hypotension

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05922514·Recruiting

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Adult Spinal Deformity Surgery Real-World Functional Activity

for Degenerative Thoracolumbar Deformity

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05611775·Recruiting

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Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

for Anatomic Stage II Breast Cancer AJCC v8

820 locations incl. Birmingham

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05812807·Phase 3·Recruiting

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Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab

for Relapsing Multiple Sclerosis

36 locations incl. Birmingham

Sponsor: TG Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT05877963·Phase 3·Recruiting

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Free Samples for Health

for Cigarette Smoking

1 location in Minneapolis

Sponsor: Hennepin Healthcare Research Institute

Sex: All·Age: 18+

Code: NCT05627596·Phase 2·Enrolling By Invitation

The Effects of Exercise on Immune Phenotype of Indolent Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia Patients

for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

2 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT05876923·Recruiting

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Alzheimer's Disease Neuroimaging Initiative 4

for Mild Cognitive Impairment

59 locations incl. Birmingham

Sponsor: University of Southern California

Sex: All·Age: 55 - 90·Accepts healthy volunteers

Code: NCT05617014·Enrolling By Invitation

ASSESSING THE GAY MALE EXPERIENCE WITH ANAL CANCER PREVENTION STRATEGIES

for Anal Cancer

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: Male·Age: 18+·Accepts healthy volunteers

Code: NCT05628194·Recruiting

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SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

for Glioma

40 locations incl. Birmingham

Sponsor: Nuvation Bio Inc.

Sex: All·Age: 18+

Code: NCT05303519·Phase 3·Recruiting

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Optimal Duration of Spinal Cord Stimulation Trial Procedure: Length and Diagnostic Accuracy

for Chronic Pain

4 locations incl. Baltimore

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18+

Code: NCT07016581·Enrolling By Invitation

MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma

for Recurrent Melanoma (Skin)

Drug: Nivolumab

13 locations incl. Orange

Sponsor: Perspective Therapeutics

Sex: All·Age: 18 - 90

Code: NCT05655312·Phase 1, Phase 2·Recruiting

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A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection

for Spontaneous Coronary Artery Dissection

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT05699200·Recruiting

Apply to this trial

Ventilatory Parameters in Predicting Outcomes in ARDS Patients

for ARDS

1 location in Saint Cloud

Sponsor: CentraCare

Sex: All·Age: 19 - 80

Code: NCT06400095·Recruiting

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Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial

for Opioid Use Disorder

3 locations incl. Arcata

Sponsor: University of New Mexico

Sex: All·Age: 18+

Code: NCT06565416·Recruiting

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PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation

for Infections

13 locations incl. Indianapolis

Sponsor: Major Extremity Trauma Research Consortium

Sex: All·Age: 18+

Code: NCT05699174·Phase 3·Recruiting

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A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)

for Advanced Solid Tumor

5 locations incl. Scottsdale

Sponsor: GI Innovation, Inc.

Sex: All·Age: 18+

Code: NCT05824975·Phase 1, Phase 2·Recruiting

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Comparison of EVAR and ESAR for Infrarenal Aortic Aneurysms With a Wide Proximal Neck

for Aortic Aneurysm, Abdominal

16 locations incl. Washington

Sponsor: Rijnstate Hospital

Sex: All·Age: 18+

Code: NCT05484115·Recruiting

Apply to this trial