A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma

Part of paid clinical trials in Aurora, Colorado.

Sponsor
Bristol-Myers Squibb
Study ID
NCT05827016
Phase
PHASE3
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Iberdomide — DRUG
    Specified dose on specified days
  • Lenalidomide — DRUG
    Specified dose on specified days

Study Details

The purpose of this study is to compare the effectiveness of iberdomide maintenance to lenalidomide maintenance therapy after autologous stem cell transplantation (ASCT) in participants with newly diagnosed multiple myeloma (NDMM).

Key Dates

First listed
Apr 24, 2023
Start date
Jun 22, 2023
Status verified
Sep 2026
Primary completion
Mar 15, 2029
Completion
Jan 1, 2036

Study Design

Enrollment
1,230 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Arm A1: Iberdomide Dose 1
  • Experimental: Arm A2: Iberdomide Dose 2
  • Experimental: Arm A3: Iberdomide Dose 3
  • Active Comparator: Arm B: Lenalidomide

Primary Outcome Measure

Progression-free survival (PFS) [ Time Frame: Up to 6 years ]

Locations (44)

FacilityCityStateZIPSite coordinators
Local Institution - 0202AuroraColorado80012-5405-
Local Institution - 0007JacksonvilleFlorida32224-1865-
Local Institution - 0192TampaFlorida33612-9416-
Local Institution - 0308TampaFlorida33606-
Local Institution - 0003WestonFlorida33331-3609-
Local Institution - 0019AthensGeorgia30607-1465-
Local Institution - 0018AtlantaGeorgia30322-1013-
Local Institution - 0021AugustaGeorgia30912-
Local Institution - 0237ChicagoIllinois60637-1426-
University of Kansas Cancer Center - The Richard and Annette Bloch Cancer Care PavilionWestwoodKansas66205-2003-
Local Institution - 0205ClintonMaryland20735-4230-
Local Institution - 0279WorcesterMassachusetts01655-
Local Institution - 0001Ann ArborMichigan48109-5000-
Local Institution - 0257DetroitMichigan48202-2610-
Local Institution - 0296Grand RapidsMichigan49503-
Local Institution - 0303RochesterMinnesota55905-
Local Institution - 0207HattiesburgMississippi39401-
Local Institution - 0191MorristownNew Jersey07960-
Local Institution - 0328BrooklynNew York11220-3313-
Local Institution - 0288MineolaNew York11501-
Local Institution - 0020New YorkNew York10032-3729-
Local Institution - 0180New YorkNew York10016-6402-
Local Institution - 0274WestburyNew York11590-5119-
Local Institution - 0005CharlotteNorth Carolina28803-2493-
Local Institution - 0331CharlotteNorth Carolina28204-
Local Institution - 0281DurhamNorth Carolina27705-3976-
Local Institution - 0286Winston-SalemNorth Carolina27103-
Local Institution - 0322Winston-SalemNorth Carolina27157-
Local Institution - 0238CincinnatiOhio45236-2725-
Local Institution - 0002ClevelandOhio44195-
Local Institution - 0299ClevelandOhio44111-
Local Institution - 0017KansasOhio64132-
Local Institution - 0301Mayfield HeightsOhio44124-
Local Institution - 0013ToledoOhio43623-
Local Institution - 0300WoosterOhio44691-
Local Institution - 0203EugeneOregon97401-
Local Institution - 0011PhiladelphiaPennsylvania19111-2433-
Local Institution - 0012PhiladelphiaPennsylvania19107-
Local Institution - 0253PittsburghPennsylvania15232-
Local Institution - 0294GermantownTennessee38138-1762-
Local Institution - 0004NashvilleTennessee37203-1625-
Local Institution - 0009DallasTexas75390-0001-
Local Institution - 0193DallasTexas75246-
Local Institution - 0006HoustonTexas77030-

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By condition
Multiple myeloma
By specialty
OncologyBlood cancer
By research site
Local Institution - 0202· Aurora, COLocal Institution - 0007· Jacksonville, FLLocal Institution - 0192· Tampa, FLLocal Institution - 0308· Tampa, FLLocal Institution - 0003· Weston, FLLocal Institution - 0019· Athens, GA

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