A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma

Part of paid clinical trials in Aurora, Colorado.

Sponsor
Bristol-Myers Squibb
Study ID
NCT05827016
Phase
PHASE3
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Iberdomide — DRUG
    Specified dose on specified days
  • Lenalidomide — DRUG
    Specified dose on specified days

Study Details

The purpose of this study is to compare the effectiveness of iberdomide maintenance to lenalidomide maintenance therapy after autologous stem cell transplantation (ASCT) in participants with newly diagnosed multiple myeloma (NDMM).

Key Dates

First listed
Apr 24, 2023
Start date
Jun 22, 2023
Status verified
Jun 2026
Primary completion
Mar 15, 2029
Completion
Jan 1, 2036

Study Design

Enrollment
1,230 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Arm A1: Iberdomide Dose 1
  • Experimental: Arm A2: Iberdomide Dose 2
  • Experimental: Arm A3: Iberdomide Dose 3
  • Active Comparator: Arm B: Lenalidomide

Primary Outcome Measure

Progression-free survival (PFS) [ Time Frame: Up to 6 years ]

Locations (44)

FacilityCityStateZIPSite coordinators
Rocky Mountain Cancer CentersAuroraColorado80012-5405-
Mayo Clinic Hospital - FloridaJacksonvilleFlorida32224-1865-
H. Lee Moffitt Cancer Center & Research InstituteTampaFlorida33612-9416-
Local Institution - 0308TampaFlorida33606-
Cleveland ClinicWestonFlorida33331-3609-
University Cancer & Blood CenterAthensGeorgia30607-1465-
The Winship Cancer Institute of Emory UniversityAtlantaGeorgia30322-1013-
Augusta University - Georgia Cancer CenterAugustaGeorgia30912-
Local Institution - 0237ChicagoIllinois60637-1426-
University of Kansas Cancer Center - The Richard and Annette Bloch Cancer Care PavilionWestwoodKansas66205-2003-
Maryland Oncology Hematology, PA- ClintonClintonMaryland20735-4230-
UMass Memorial Medical CenterWorcesterMassachusetts01655-
University of Michigan - Rogel Cancer CenterAnn ArborMichigan48109-5000-
Henry Ford Health System - The Henry Ford Cancer Institute (HFCI) - DetroitDetroitMichigan48202-2610-
Cancer & Hematology Centers of Western Michigan (CHCWM)Grand RapidsMichigan49503-
Mayo Clinic Cancer Center (MCCC) - RochesterRochesterMinnesota55905-
Hattiesburg Clinic - Hematology & OncologyHattiesburgMississippi39401-
Morristown Medical CenterMorristownNew Jersey07960-
Perlmutter Cancer Center - Sunset ParkBrooklynNew York11220-3313-
Perlmutter Cancer Center at NYU Langone Hematology Oncology Associates-MineolaMineolaNew York11501-
Columbia University Medical Center - Herbert Irving Pavilion LocationNew YorkNew York10032-3729-
NYU Langone HealthNew YorkNew York10016-6402-
Optum Medical Care PCWestburyNew York11590-5119-
Levine Cancer InstituteCharlotteNorth Carolina28204-
Novant Health Cancer Institute - ElizabethCharlotteNorth Carolina28803-2493-
Duke University HospitalDurhamNorth Carolina27705-3976-
Novant Health Cancer Institute Hematology - ForsythWinston-SalemNorth Carolina27103-
Wake Forest University Baptist Medical Center (WFUBMC) - Comprehensive Cancer CenterWinston-SalemNorth Carolina27157-
Oncology Hematology Care, Inc. - Cincinnati - Galbraith RdCincinnatiOhio45236-2725-
Cleveland ClinicClevelandOhio44195-
Cleveland Clinic - Fairview Hospital - Cancer Center (Moll Cancer Center)ClevelandOhio44111-
Midwest Oncology Associates - Kansas CityKansasOhio64132-
Cleveland Clinic - Hillcrest Hospital - Hillcrest Cancer CenterMayfield HeightsOhio44124-
Local Institution - 0013ToledoOhio43623-
Wooster Milltown Specialty and Surgery CenterWoosterOhio44691-
Willamette Valley Cancer InstituteEugeneOregon97401-
Fox Chase Cancer Center - Jeanes CampusPhiladelphiaPennsylvania19111-2433-
Thomas Jefferson University HospitalPhiladelphiaPennsylvania19107-
Local Institution - 0253PittsburghPennsylvania15232-
West Cancer CenterGermantownTennessee38138-1762-
Local Institution - 0004NashvilleTennessee37203-1625-
Texas Oncology - Baylor Charles A. Sammons Cancer CenterDallasTexas75246-
University of Texas Southwestern Harold C. Simmons Comprehensive Cancer CenterDallasTexas75390-0001-
The University of Texas MD Anderson Cancer CenterHoustonTexas77030-

Find similar trials in Aurora, CO

By condition
Multiple myeloma
By specialty
OncologyBlood cancer
By research site
Rocky Mountain Cancer Centers· Aurora, COMayo Clinic Hospital - Florida· Jacksonville, FLH. Lee Moffitt Cancer Center & Research Institute· Tampa, FLLocal Institution - 0308· Tampa, FLCleveland Clinic· Weston, FLUniversity Cancer & Blood Center· Athens, GA

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