Paid Clinical Trials in Naples, FL

As of August 2026, 95 paid clinical trials are recruiting in Naples, Florida. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 10, 2026.

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88 clinical trials

Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis

for Ulcerative Colitis

Sites in Naples, Coral Gables +36 more locations

Sponsor: Gilead Sciences

Sex: All·Age: 18 - 75

Code: NCT06029972·Phase 2·Recruiting·Listed Sep 2023

Apply to this trial

RESTORE TRIAL: A Phase 2 Study Evaluating the Efficacy and Safety of Pemvidutide in the Treatment of Alcohol-Associated Liver Disease (ALD)

for Alcohol Liver Disease

Drug: Pemvidutide

Sites in Naples, Fort Myers +40 more locations

Sponsor: Altimmune, Inc.

Sex: All·Age: 18 - 75

Code: NCT07009860·Phase 2·Recruiting·Listed Jun 2025

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A Study of Assessment on Safety and Effectiveness of BWI Pulsed Field Ablation With OMNYPULSE Catheter for the Treatment of Paroxysmal Atrial Fibrillation (PAF)

for Atrial Fibrillation

Sites in Naples, Miami +37 more locations

Sponsor: Biosense Webster, Inc.

Sex: All·Age: 18 - 80

Code: NCT06455098·Recruiting·Listed Jun 2024

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AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

for Obesity

Drug: NNC0487-0111

Sites in Naples, Bradenton +18 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07571109·Phase 3·Recruiting·Listed May 2026

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AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

for Obesity

Drug: NNC0487-0111

Sites in Naples, Miami +15 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07571005·Phase 3·Recruiting·Listed May 2026

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A Study of VARIPULSE Pulsed Field Ablation (PFA) Catheter and FARAWAVE PFA Catheter in the Treatment of Participants With Persistent Atrial Fibrillation

for Atrial Fibrillation

Sites in Naples, Miami +28 more locations

Sponsor: Biosense Webster, Inc.

Sex: All·Age: 18 - 80

Code: NCT07523750·Recruiting·Listed Apr 2026

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AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

for Obesity

Drug: NNC0487-0111

Sites in Naples, Jacksonville +17 more locations

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07509307·Phase 3·Recruiting·Listed Apr 2026

Apply to this trial

Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis

for Multiple Sclerosis

Drug: Frexalimab

Sites in Naples, West Palm Beach +20 more locations

Sponsor: Sanofi

Sex: All·Age: 18 - 60

Code: NCT07325292·Phase 3·Recruiting·Listed Jan 2026

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A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)

for Bipolar Disorder

Drug: Brenipatide

Sites in Naples, Weston +18 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07286175·Phase 2·Recruiting·Listed Dec 2025

Apply to this trial

Horizon 360 Protocol for the Treatment of Paroxysmal Atrial Fibrillation With the Sphere-360™ Catheter and Affera™ Mapping and Ablation System (Horizon 360)

for Paroxysmal AF

Sites in Naples +23 more locations

Sponsor: Medtronic Cardiac Ablation Solutions

Sex: All·Age: 18 - 80

Code: NCT07308847·Recruiting·Listed Dec 2025

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Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)

for Atrial Fibrillation (AF)

Sites in Naples, Orlando +20 more locations

Sponsor: Medtronic Cardiac Ablation Solutions

Sex: All·Age: 18+

Code: NCT07298473·Recruiting·Listed Dec 2025

Apply to this trial

A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis

for Secondary Progressive Multiple Sclerosis

Sites in Naples, Bradenton +16 more locations

Sponsor: Zenas BioPharma (USA), LLC

Sex: All·Age: 18 - 60

Code: NCT07299019·Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

ATLAS (AltaValve) Pivotal Trial

for Mitral Regurgitation

Sites in Naples, Sarasota +34 more locations

Sponsor: 4C Medical Technologies, Inc.

Sex: All·Age: 18+

Code: NCT06465745·Recruiting·Listed Jun 2024

Apply to this trial

A Study to Assess the Efficacy and Safety of Empasiprubart in Adults With CIDP

for Chronic Inflammatory Demyelinating Polyneuropathy

Sites in Naples, Miami +7 more locations

Sponsor: argenx

Sex: All·Age: 18+

Code: NCT07091630·Phase 3·Recruiting·Listed Jul 2025

Apply to this trial

Assessment of Support With Impella® Best Practices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

for AMI Cardiogenic Shock

Sites in Naples +17 more locations

Sponsor: Abiomed Inc.

Sex: All·Age: 18+

Code: NCT06964685·Recruiting·Listed May 2025

Apply to this trial

Galvanize Prospective/Retrospective Pulsed Electric Field Device Registry

for Soft Tissue Lesion

Sites in Naples +10 more locations

Sponsor: Galvanize Therapeutics, Inc.

Sex: All·Age: 18 - 100

Code: NCT05851430·Recruiting·Listed May 2023

Apply to this trial

A Study of LY4006895 in Healthy Participants With Early Symptomatic Alzheimer's Disease (AD)

for Alzheimer Disease

Drug: LY4006895

Sites in Naples, Tampa +9 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 45 - 85·Accepts healthy volunteers

Code: NCT06657768·Phase 1·Recruiting·Listed Oct 2024

Apply to this trial

Treating Pulmonary Embolism With Laguna Thrombectomy System (TRUST)

for Pulmonary Embolism

Sites in Naples, Bradenton +11 more locations

Sponsor: Innova Vascular, Inc.

Sex: All·Age: 18 - 85

Code: NCT06041594·Recruiting·Listed Sep 2023

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A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity

for Multiple Sclerosis Spasticity

Sites in Naples, Tampa +11 more locations

Sponsor: Celgene

Sex: All·Age: 18 - 70

Code: NCT06782490·Phase 2·Recruiting·Listed Jan 2025

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A Study of LY4006896 in Healthy Participants and Participants With Parkinson's Disease

for Parkinson Disease

Drug: LY4006896

Sites in Naples, Orlando +9 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 30 - 85·Accepts healthy volunteers

Code: NCT06809400·Phase 1·Recruiting·Listed Feb 2025

Apply to this trial

Observational, Non-Interventional Study Supporting Validation of VO2Max Estimation Methods Using Results in Patients Receiving Standard of Care Cardiopulmonary Exercise Tests (CPET)

for Cardiopulmonary

Sites in Naples, Hollywood +11 more locations

Sponsor: Prolaio

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05678530·Recruiting·Listed Jan 2023

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Phase 2 Study of Inhaled SNG001 in Mechanically Ventilated Patients With Respiratory Viral Infection

for Viral Pneumonia

Sites in Naples +21 more locations

Sponsor: Synairgen Research Ltd.

Sex: All·Age: 18+

Code: NCT06999603·Phase 2·Recruiting·Listed May 2025

Apply to this trial

TVMR With the INNOVALVE System Trial - Early Feasibility Study

for Mitral Valve Regurgitation (Degenerative or Functional)

Sites in Naples +18 more locations

Sponsor: Edwards Lifesciences

Sex: All·Age: 18+

Code: NCT04919980·Recruiting·Listed Jun 2021

Apply to this trial

A Retrospective Assessment of OviTex PRS (OviTex)

for Reconstructive Surgical Procedures

Sites in Naples, South Miami +5 more locations

Sponsor: Tela Bio Inc

Sex: Female·Age: 18 - 75

Code: NCT05736848·Recruiting·Listed Feb 2023

Apply to this trial

Case-Specific Health Care Professional Clinical Survey of Liberant™ Thrombectomy System

for Venous Embolism of Lower Extremities (Diagnosis)

Sites in Naples +2 more locations

Sponsor: Medtronic Endovascular

Sex: All·Age: 22+

Code: NCT07335341·Recruiting·Listed Jan 2026

Apply to this trial

DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Real-World Setting

for Transthyretin Amyloidosis With Cardiomyopathy

Sites in Naples +3 more locations

Sponsor: Alnylam Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07358078·Recruiting·Listed Jan 2026

Apply to this trial

Endocardial Mapping With the CoreMap EP Mapping System

for Persistent Atrial Fibrillation

Sites in Naples +2 more locations

Sponsor: CoreMap Inc.

Sex: All·Age: 18 - 80

Code: NCT06529978·Recruiting·Listed Jul 2024

Apply to this trial

A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)

for Alzheimer Disease

Drug: KarXT

Sites in Naples +4 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 55 - 90

Code: NCT06947941·Phase 3·Recruiting·Listed Apr 2025

Apply to this trial

A Phase 1b/2 Study of IM-101 in Adult Participants With Generalized Myasthenia Gravis and Ocular Myasthenia Gravis

for Myasthenia Gravis

Sites in Naples, Port Charlotte +6 more locations

Sponsor: ImmunAbs Inc.

Sex: All·Age: 18 - 74

Code: NCT07250750·Phase 1, Phase 2·Recruiting·Listed Nov 2025

Apply to this trial

The WiSE®-UP Registry (The WiSE System Utilization & Performance Registry)

for Heart Failure

Sites in Naples +4 more locations

Sponsor: EBR Systems, Inc.

Sex: All·Age: All ages

Code: NCT07098858·Recruiting·Listed Aug 2025

Apply to this trial

Trial of the F2 Filter and Delivery System for Embolic Protection During TAVR

for Aortic Stenosis Treated With TAVI

Sites in Naples +7 more locations

Sponsor: EnCompass Technologies, Inc.

Sex: All·Age: 50+

Code: NCT06689839·Recruiting·Listed Nov 2024

Apply to this trial

Outcome Research to Confirm the Anti-anginal Effect of T89 in Patients With Stable Angina

for Chronic Stable Angina Pectoris

1 location in Naples

Sponsor: Tasly Pharmaceuticals, Inc.

Sex: All·Age: 18 - 90

Code: NCT03789552·Phase 3·Recruiting·Listed Dec 2018

Apply to this trial

Unconscious Mind Training

for Memory Encoding

1 location in Naples

Sponsor: Dream Video LLC

Sex: All·Age: 10 - 75·Accepts healthy volunteers

Code: NCT07597603·Recruiting·Listed May 2026

Apply to this trial

Real-world Experience of Catheter Ablation for the Treatment of Arrhythmias

for Paroxysmal Atrial Fibrillation

Sites in Naples, Sarasota +62 more locations

Sponsor: Heart Rhythm Clinical and Research Solutions, LLC

Sex: All·Age: 18+

Code: NCT04088071·Recruiting·Listed Sep 2019

Apply to this trial

Patients With Congenital Myasthenic Syndrome Will be Treated With Mesenchymal Stem Cell Exosome Solution

for Congenital Myasthenic Syndrome

Sites in Naples +1 more location

Sponsor: The Foundation for Orthopaedics and Regenerative Medicine

Sex: All·Age: 18+

Code: NCT07226726·Phase 1·Recruiting·Listed Nov 2025

Apply to this trial

Efficacy and Safety of Leadless Pacemakers Versus Left Bundle Area Pacing - A Preliminary Exploration

for Pacemaker Implantation

Sites in Naples +1 more location

Sponsor: NCH Healthcare System, Inc. dba Naples Comprehensive Health and dba NCH

Sex: All·Age: 18+

Code: NCT06690333·Recruiting·Listed Nov 2024

Apply to this trial

Safety and Efficacy of Workflows of High Volume Single Operators in a LAAO Device Implant Procedural Day

for Atrial Fibrillation

Sites in Naples, Jacksonville +5 more locations

Sponsor: Heart Rhythm Clinical and Research Solutions, LLC

Sex: All·Age: 18+

Code: NCT06436924·Recruiting·Listed May 2024

Apply to this trial

A Study to Assess the Effectiveness and Safety of GSK3862995B in Adults With Bronchiectasis

for Bronchiectasis

Sites in Naples, Plantation +12 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 18 - 85

Code: NCT07201051·Phase 2·Recruiting·Listed Oct 2025

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A Study to Evaluate the Efficacy, Safety, and PK of AZD0292 Administered IV in Participants 12 Years of Age and Older With Bronchiectasis and Chronic Pseudomonas Aeruginosa Colonization

for Bronchiectasis With Pseudomonas Aeruginosa Colonization

Sites in Naples, Plantation +18 more locations

Sponsor: AstraZeneca

Sex: All·Age: 12+

Code: NCT07088926·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

for Chronic Obstructive Pulmonary Disease (COPD)

Sites in Naples, Cape Coral +74 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40+

Code: NCT07082738·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial