Paid Clinical Trials in North Carolina

North Carolina has 2,804 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,435 clinical trials

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Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

Drug: Tremelimumab

Sites in Winston-Salem, Clemmons +21 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03606967·Phase 2·Recruiting·Listed Jul 2018

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Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

for Recurrent Glioblastoma, IDH-Wildtype

Drug: Selinexor

Sites in Winston-Salem +27 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05432804·Phase 1, Phase 2·Recruiting·Listed Jun 2022

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Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

for Migraine

Sites in Winston-Salem, Charlotte +34 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 70

Code: NCT06972056·Phase 4·Recruiting·Listed May 2025

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QuantifyHER: Quantitative Immunofluorescence and/or RT-qPCR for Measuring HER2 in HER2-low Metastatic Breast Cancer

for HER2-positive Metastatic Breast Cancer

Sites in Chapel Hill +36 more locations

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06551116·Recruiting·Listed Aug 2024

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Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry

for Rheumatic Joint Disease

Sites in Durham, Chapel Hill +64 more locations

Sponsor: Duke University

Sex: All·Age: Up to 21

Code: NCT02418442·Recruiting·Listed Apr 2015

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ONC-MM-2407: The Effect of Virtual Reality Headsets on Pain and Anxiety in the Peri and Post Bone Marrow Biopsy Period

for Hematologic Malignancy

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07203534·Recruiting·Listed Oct 2025

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Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial

for Surgery

Sites in Chapel Hill +5 more locations

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT05722002·Phase 4·Recruiting·Listed Feb 2023

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Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants

for Inherited Retinal Degeneration

Sites in Durham +18 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4+

Code: NCT05589714·Recruiting·Listed Oct 2022

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A Phase 1b Study of Menin Inhibitor SNDX- 5613 in Combination With Daunorubicin and Cytarabine in Newly Diagnosed Patients With Acute Myeloid Leukemia and NPM1 Mutated/FLT3 Wildtype or MLL/KMT2A Rearranged or NUP98 Alterations Disease

for Acute Myeloid Leukemia

Sites in Chapel Hill, Winston-Salem +19 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 75

Code: NCT05886049·Phase 1·Recruiting·Listed Jun 2023

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Cytomegalovirus (CMV) Vaccine in Orthotopic Liver Transplant Candidates

for Liver Transplant

Sites in Durham +16 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18+

Code: NCT06075745·Phase 2·Recruiting·Listed Oct 2023

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PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

for High Grade Glioma

Sites in Durham +12 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 3 - 39

Code: NCT05096481·Phase 2·Recruiting·Listed Oct 2021

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Streamlined Treatment of Pulmonary Exacerbations in Pediatrics

for Cystic Fibrosis

Sites in Chapel Hill +30 more locations

Sponsor: University of Washington, the Collaborative Health Studies Coordinating Center

Sex: All·Age: 3 - 18

Code: NCT06654752·Recruiting·Listed Oct 2024

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International CRDS Registry

for Calcium Release Deficiency Syndrome

Sites in Durham +3 more locations

Sponsor: Population Health Research Institute

Sex: All·Age: All ages

Code: NCT06508164·Recruiting·Listed Jul 2024

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Nutrition Awareness Among Women With Non-Metastatic Breast Cancer

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT07389967·Recruiting·Listed Feb 2026

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Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL

for B-cell Acute Lymphoblastic Leukemia

Sites in Charlotte +15 more locations

Sponsor: Etan Orgel

Sex: All·Age: 7 - 25

Code: NCT05082519·Phase 2·Recruiting·Listed Oct 2021

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Testing the Addition of Abemaciclib to Olaparib for Women With Recurrent Ovarian Cancer

for Recurrent Ovarian High Grade Serous Adenocarcinoma

Sites in Winston-Salem +10 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT04633239·Phase 1·Recruiting·Listed Nov 2020

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Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts

for Breast Cancer

Sites in Greenville +10 more locations

Sponsor: American College of Radiology

Sex: Female·Age: 45 - 74·Accepts healthy volunteers

Code: NCT05625659·Recruiting·Listed Nov 2022

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Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors

for Malignant Solid Neoplasm

Sites in Greensboro, Asheville +586 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04871542·Recruiting·Listed May 2021

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Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

for Metastatic Colorectal Carcinoma

Sites in Durham, Winston-Salem +52 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT05863195·Phase 3·Recruiting·Listed May 2023

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Tirzepatide in Obesity-Driven Endometrial Cancer

for Endometrial Cancer

Drug: Tirzepatide

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT07065552·EARLY_Phase 1·Recruiting·Listed Jul 2025

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Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

for Acute Respiratory Distress Syndrome

Sites in Durham, Winston-Salem +31 more locations

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06066502·Phase 3·Recruiting·Listed Oct 2023

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Validation of a Platelet Proteomic Assay for Diagnosing and Monitoring Prostate Cancer

for Prostate Cancer (Diagnosis)

1 location in Durham

Sponsor: Duke University

Sex: Male·Age: 40+

Code: NCT07144228·Recruiting·Listed Aug 2025

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Cord Clamping Among Neonates With Congenital Heart Disease

for Congenital Heart Disease (CHD)

Sites in Durham +17 more locations

Sponsor: Carl Backes, MD

Sex: All·Age: 37 Weeks - 42 Weeks

Code: NCT06153459·Recruiting·Listed Dec 2023

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Resilience Enhancement Using Electronic Frailty Index-Directed Care Pathway

for Cancer

Sites in Winston-Salem & Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 65+

Code: NCT07175376·Recruiting·Listed Sep 2025

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The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study

for Ischemic Heart Disease (IHD)

Sites in Charlotte +12 more locations

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 35 - 85

Code: NCT06854458·Recruiting·Listed Mar 2025

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Belumosudil to Block Chronic Lung Allograft Dysfunction (CLAD) in High Risk Lung Transplant Recipients

for Lung Transplant

Sites in Durham +10 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 12+

Code: NCT06476132·Phase 2·Recruiting·Listed Jun 2024

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Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)

for T-cell Acute Lymphoblastic Leukemia

Drug: Venetoclax

Sites in Charlotte +3 more locations

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 1 - 18

Code: NCT06390319·Phase 2·Recruiting·Listed Apr 2024

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An International Observational Study of Adults With Acute Infection

for Infectious Disease

Sites in Durham, Winston-Salem +18 more locations

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT07069400·Recruiting·Listed Jul 2025

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Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

for Rectal Cancer

Sites in Greenville +102 more locations

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT06205485·Phase 3·Recruiting·Listed Jan 2024

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Functional Assessment in Liver Transplantation

for End Stage Liver Disease

Sites in Durham +7 more locations

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT03228290·Recruiting·Listed Jul 2017

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CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

for Traumatic Brain Injury

Sites in Fort Bragg +4 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT05663034·Recruiting·Listed Dec 2022

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Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes

for Lung Transplant

Sites in Durham +17 more locations

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06399302·Recruiting·Listed May 2024

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Anesthetics and Analgesics in Children

for Anesthesia

Sites in Durham +3 more locations

Sponsor: Chi Dang Hornik

Sex: All·Age: 0 - 17

Code: NCT03427736·Recruiting·Listed Feb 2018

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DCIS: RECAST Trial Ductal Carcinoma In Situ: Re-Evaluating Conditions for Active Surveillance Suitability as Treatment

for Ductal Carcinoma in Situ

Sites in Durham, Winston-Salem +23 more locations

Sponsor: QuantumLeap Healthcare Collaborative

Sex: Female·Age: 18+

Code: NCT06075953·Phase 2·Recruiting·Listed Oct 2023

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Molecular Residual Disease Assessment in a Representative Diverse Population of Patients With Early-stage Breast Cancer

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07025785·Recruiting·Listed Jun 2025

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Inhaled Treprostinil (Tyvaso Nebulizer) For COPD Patients With Hypoxemia

for COPD (Chronic Obstructive Pulmonary Disease)

1 location in Durham

Sponsor: Bastiaan Driehuys

Sex: All·Age: 40+

Code: NCT07037836·Phase 2·Recruiting·Listed Jun 2025

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Dental-Child Interaction Training

for Behavior and Behavior Mechanisms

Sites in Chapel Hill +3 more locations

Sponsor: University of Florida

Sex: All·Age: 18 - 99

Code: NCT06138405·Recruiting·Listed Nov 2023

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Testing the Effectiveness of the Anti-cancer Drug, Mirdametinib, in Treating Relapsed, Refractory Chronic Lymphocytic Leukemia

for Recurrent Chronic Lymphocytic Leukemia

Drug: Mirdametinib

Sites in Chapel Hill +7 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07061951·Phase 2·Recruiting·Listed Jul 2025

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ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas

for Diffuse Intrinsic Pontine Gliomas (DIPG)

Sites in Durham +11 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT06838676·Phase 2·Recruiting·Listed Feb 2025

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De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

for Stage I Breast Cancer

Sites in Winston-Salem, Charlotte +705 more locations

Sponsor: NRG Oncology

Sex: All·Age: 50 - 70

Code: NCT04852887·Phase 3·Recruiting·Listed Apr 2021

Apply to this trial