Paid Clinical Trials in North Carolina

North Carolina has 2,804 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,435 clinical trials

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Hyperpolarized 129Xe MRI for Imaging Pulmonary Function

for Interstitial Lung Disease

1 location in Durham

Sponsor: Bastiaan Driehuys

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT01280994·Phase 2·Recruiting·Listed Jan 2011

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Mitigating PTSD-CUD After Sexual Assault

for Posttraumatic Stress Disorder

Sites in Chapel Hill, Smithfield +4 more locations

Sponsor: University of Nevada, Las Vegas

Sex: Female·Age: 18+

Code: NCT05989841·Phase 1, Phase 2·Recruiting·Listed Aug 2023

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Nutrition and Obesity in Under-Represented Populations: Food Insecurity Research to Advance Science and Improve Health

for Pediatric Obesity

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 12 Months - 24 Months·Accepts healthy volunteers

Code: NCT06116422·Recruiting·Listed Nov 2023

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Adolescent Mood During Puberty and Testosterone

for Adolescent Depression

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 11 - 14·Accepts healthy volunteers

Code: NCT06072677·Recruiting·Listed Oct 2023

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Tumor Subtypes in Subjects on FOLFIRINOX With Non-Metastatic Pancreatic Cancer

for Pancreatic Ductal Adenocarcinoma (PDAC)

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 99

Code: NCT03977233·Phase 2·Recruiting·Listed Jun 2019

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Biomarker Development for Muscular Dystrophies

for Myotonic Dystrophy

Sites in Winston-Salem +3 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 5+·Accepts healthy volunteers

Code: NCT05019625·Recruiting·Listed Aug 2021

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Opioids, Low Nicotine Cigarettes, and Chronic Pain

for Chronic Pain

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT06747871·Recruiting·Listed Dec 2024

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OUD (Opioid Use Disorder) Target Trial

for Opioid Use Disorder

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06585709·Recruiting·Listed Sep 2024

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Rare Glycogen Storage Diseases Natural History Study

for Glycogen Storage Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 0 - 90

Code: NCT06795152·Recruiting·Listed Jan 2025

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Duke Lupus Registry

for Systemic Lupus Erythematosus

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT00512694·Recruiting·Listed Aug 2007

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Maternal Autoimmune Disease Research Alliance (MADRA) Registry

for Autoimmune Diseases

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: All ages·Accepts healthy volunteers

Code: NCT03276923·Recruiting·Listed Sep 2017

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E-PRIME For Children With Medical Complexity

for Children With Medical Complexity

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: Up to 17

Code: NCT06216548·Recruiting·Listed Jan 2024

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Health Outcomes of Parents With Cystic Fibrosis-Aim 2

for Cystic Fibrosis

Sites in Chapel Hill +17 more locations

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT06296394·Recruiting·Listed Mar 2024

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Abdominal Wall Transplant

for Transplant

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 65

Code: NCT03310905·Recruiting·Listed Oct 2017

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Pharmacokinetics of Drugs Administered to Children

for Pediatric ALL

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 0 - 20

Code: NCT03481881·Recruiting·Listed Mar 2018

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Phase 2 Study of Glofitamab Monotherapy & With Polatuzumab Vedotin, Pirtobrutinib, or Atezolizumab in Richter's Transformation

for Chronic Lymphocytic Leukemia

Drug: Polatuzumab Vedotin

Sites in Chapel Hill +4 more locations

Sponsor: Christine Ryan

Sex: All·Age: 18+

Code: NCT06043674·Phase 2·Recruiting·Listed Sep 2023

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OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages

for Eosinophilic Gastrointestinal Disorders (EGIDs)

Sites in Chapel Hill +15 more locations

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 3+

Code: NCT02523118·Recruiting·Listed Aug 2015

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Pediatrics Mobile CT

for Pediatric Abdominal Imaging

1 location in Durham

Sponsor: Duke University

Sex: All·Age: Up to 5

Code: NCT07166926·Recruiting·Listed Sep 2025

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Eat Well Heart Failure

for Congestive Heart Failure Chronic

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07101289·Recruiting·Listed Aug 2025

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High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers

for Metastatic Prostate Cancer

Sites in Durham, Salisbury +15 more locations

Sponsor: VA Office of Research and Development

Sex: Male·Age: 18+

Code: NCT05011383·Phase 2·Recruiting·Listed Aug 2021

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Multimedia Aid for Genetic Testing in Gynecologic Oncology

for Ovary Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 18+

Code: NCT07084168·Recruiting·Listed Jul 2025

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Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

for Pain

Sites in Durham, Greenville +12 more locations

Sponsor: University of Pittsburgh

Sex: All·Age: 16 - 30

Code: NCT06374238·Recruiting·Listed Apr 2024

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Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

for Cutaneous Melanoma, Stage II

Sites in Durham, Chapel Hill +128 more locations

Sponsor: Melanoma and Skin Cancer Trials Limited

Sex: All·Age: 18+

Code: NCT03860883·Recruiting·Listed Mar 2019

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The ExTINGUISH Trial of Inebilizumab in NMDAR Encephalitis

for Autoimmune Encephalitis

Drug: Inebilizumab

Sites in Winston-Salem +34 more locations

Sponsor: University of Utah

Sex: All·Age: 12+

Code: NCT04372615·Phase 2·Recruiting·Listed May 2020

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Designing Visual Tools to Enhance Cancer Surgeon Decision-making

for Prostate Cancer

Sites in Chapel Hill & Wilmington

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06965192·Recruiting·Listed May 2025

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Efficacy of 3D-Printed Mouth Splints

for Microstomia

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 2 - 99

Code: NCT06801535·Recruiting·Listed Jan 2025

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Pilot Study of Fisetin to Improve Fatigue Among Older Adult Cancer Survivors

for Fatigue

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT06819254·Phase 4·Recruiting·Listed Feb 2025

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Total Intravenous Anesthesia (TIVA)/Sevoflurane Initiated Intravenous Anesthesia (SIIVA) in Pediatric Patients

for Extubation

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: Up to 9

Code: NCT05837936·Recruiting·Listed May 2023

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Mobile Neurofeedback for Low Back Pain

for Chronic Low Back Pain

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT05669027·Recruiting·Listed Dec 2022

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Rare and Atypical Diabetes Network

for Diabetes Mellitus

Sites in Chapel Hill +12 more locations

Sponsor: University of South Florida

Sex: All·Age: All ages

Code: NCT05544266·Recruiting·Listed Sep 2022

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Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)

for Hypertension

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 7 - 18·Accepts healthy volunteers

Code: NCT04752293·Recruiting·Listed Feb 2021

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Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy

for Head and Neck Cancer

Sites in Durham +3 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT05793151·Recruiting·Listed Mar 2023

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NextGen - Clinical Implication of Next Generation Sequencing

for Urinary Tract Infections

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18 - 80

Code: NCT05206500·Phase 4·Recruiting·Listed Jan 2022

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Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia

for Pain, Postoperative

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 3 - 17·Accepts healthy volunteers

Code: NCT06576830·Phase 4·Recruiting·Listed Aug 2024

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HMCT/CT2401: Abatacept GVHD Prophylaxis Following Omidubicel HCT

for Hematologic Malignancy

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06731504·EARLY_Phase 1·Recruiting·Listed Dec 2024

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Comparative Efficacy of Organizational Skills Training (OST) and Mindfulness-Based Intervention (MBI)

for ADHD

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 13 - 17·Accepts healthy volunteers

Code: NCT07089745·Recruiting·Listed Jul 2025

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Resources for Optimizing Outcomes in Toddlers on the Spectrum

for Autism Spectrum Disorder

1 location in Carrboro

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 1 - 99

Code: NCT07086781·Recruiting·Listed Jul 2025

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Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2

for Charcot-Marie-Tooth Disease, Type Ia (Disorder)

Sites in Chapel Hill +16 more locations

Sponsor: University of Iowa

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01193088·Recruiting·Listed Sep 2010

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Excision of Lymph Node Trial (EXCILYNT) (Mel69)

for Melanoma

Sites in Durham +6 more locations

Sponsor: Craig L Slingluff, Jr

Sex: All·Age: 18+

Code: NCT05839912·Recruiting·Listed May 2023

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Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance

for Heart Failure and Reduced Ejection Fraction

Sites in Charlotte +4 more locations

Sponsor: Minneapolis Heart Institute Foundation

Sex: All·Age: 18+

Code: NCT07131631·Recruiting·Listed Aug 2025

Apply to this trial