Paid Clinical Trials in North Carolina

North Carolina has 2,804 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,435 clinical trials

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RSV Vaccine Pregnancy Registry

for Respiratory Syncytial Virus (RSV)

1 location in Wilmington

Sponsor: CorEvitas

Sex: Female·Age: 18 - 50·Accepts healthy volunteers

Code: NCT06521944·Recruiting·Listed Jul 2024

Apply to this trial

Embo Registry; National Registry for Artery Embolization

for Chronic Pain

Sites in Cary +1 more location

Sponsor: Vascular Solutions of North Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06477965·Recruiting·Listed Jun 2024

Apply to this trial

Antiretroviral Pregnancy Registry (APR): Multi-sponsor Registry to Detect Any Major Teratogenic Effect Involving Any of the Registry Drugs When Administered to Pregnant People.

for HIV Infections

1 location in Wilmington

Sponsor: Syneos Health

Sex: Female·Age: 12 - 60

Code: NCT00404989·Recruiting·Listed Nov 2006

Apply to this trial

Fundus Ablation Registry (Gastric Fundus Mucosal Ablation for Weight Loss)

for Obesity

1 location in Cary

Sponsor: True You Weight Loss

Sex: All·Age: 18 - 65

Code: NCT06428617·Recruiting·Listed May 2024

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Ablation Registry (Combined Gastric Mucosal Ablation With Endoscopic Sleeve Gastroplasty for Weight Loss)

for Obesity

Sites in Cary +1 more location

Sponsor: True You Weight Loss

Sex: All·Age: 18 - 65

Code: NCT06420700·Recruiting·Listed May 2024

Apply to this trial

Peer Interventions for Preschoolers With Autism

for Autism Spectrum Disorder

Sites in Chapel Hill +1 more location

Sponsor: University of Kansas

Sex: All·Age: 3 - 6

Code: NCT05799599·Recruiting·Listed Apr 2023

Apply to this trial

The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study

for Lupus Nephritis

Sites in Chapel Hill +18 more locations

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 8 - 20

Code: NCT05538208·Phase 2·Recruiting·Listed Sep 2022

Apply to this trial

Daratumumab in Primary Antiphospholipid Syndrome

for Autoimmune Disorders

Drug: Daratumumab

Sites in Durham +6 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 65

Code: NCT05671757·Phase 1, Phase 2·Recruiting·Listed Jan 2023

Apply to this trial

Virtual Village for Young Parents

for Gender-based Violence

1 location in Durham

Sponsor: RTI International

Sex: All·Age: 16 - 21·Accepts healthy volunteers

Code: NCT07226401·Recruiting·Listed Nov 2025

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Direct Comparison of Cardiac CT With TEE to Evaluate Watchman FLX LAA Occluder Device Characteristics

for Device Related Thrombosis

Sites in Charlotte +4 more locations

Sponsor: University Hospitals Cleveland Medical Center

Sex: All·Age: 18+

Code: NCT06523166·Recruiting·Listed Jul 2024

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Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial

for Acute Ischemic Stroke

Sites in Winston-Salem +50 more locations

Sponsor: Mercy Health Ohio

Sex: All·Age: 18 - 79

Code: NCT05611242·Phase 3·Recruiting·Listed Nov 2022

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Pulmonary Hypertension Association Registry

for Pulmonary Arterial Hypertension

Sites in Durham, Chapel Hill +50 more locations

Sponsor: Pulmonary Hypertension Association, Inc.

Sex: All·Age: 0+

Code: NCT04071327·Recruiting·Listed Aug 2019

Apply to this trial

Sitting Interruption and Whole-body Cardiovascular Health

for Sedentary Behavior

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 30 - 60·Accepts healthy volunteers

Code: NCT05316571·Recruiting·Listed Apr 2022

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Unity VCS: A Comparison Study Evaluating Corneal Clarity and Thickness

for Cataract

1 location in Matthews

Sponsor: Metrolina Eye Associates, PLLC

Sex: All·Age: 18+

Code: NCT07222150·Recruiting·Listed Oct 2025

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Neural Correlates of Real World Spatial Navigation in Humans

for Memory, Delayed

Sites in Durham +1 more location

Sponsor: Duke University

Sex: All·Age: 12 - 70·Accepts healthy volunteers

Code: NCT04874220·Recruiting·Listed May 2021

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A Food As Medicine Approach to Address Food Insecurity in Rural North Carolina

for Diet, Healthy

1 location in Raleigh

Sponsor: North Carolina State University

Sex: All·Age: 8 - 64·Accepts healthy volunteers

Code: NCT07221045·Recruiting·Listed Oct 2025

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Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

for Ischemic Stroke

Sites in Durham +27 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04916210·Recruiting·Listed Jun 2021

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Intent of Surgery for IPMN

for Intraductal Papillary Mucinous Neoplasm

Sites in Durham +7 more locations

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07216521·Recruiting·Listed Oct 2025

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Ultrasound for Quantifying Muscle Activation Elicited by Spinal Cord Stimulation and Functional Electrical Stimulation

for Neuromodulatory Effects of TSCS and FES in Lower Limbs

1 location in Raleigh

Sponsor: North Carolina State University

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT07206797·Recruiting·Listed Oct 2025

Apply to this trial

Pediatric Dose Optimization for Seizures in Emergency Medical Services

for Seizures

Sites in Charlotte +19 more locations

Sponsor: Stanford University

Sex: All·Age: 6 Months - 13

Code: NCT05121324·Phase 3·Recruiting·Listed Nov 2021

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Stent Omission After Ureteroscopy and Lithotripsy in the Michigan Urological Surgery Improvement Collaborative

for Stone, Kidney

Sites in Chapel Hill +15 more locations

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT05866081·Recruiting·Listed May 2023

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Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement

for Aortic Stenosis

Sites in Charlotte +54 more locations

Sponsor: University of British Columbia

Sex: All·Age: All ages

Code: NCT04634240·Recruiting·Listed Nov 2020

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National Collaborative to Improve Care of Children With Complex Congenital Heart Disease

for Hypoplastic Left Heart Syndrome (HLHS)

Sites in Durham, Charlotte +57 more locations

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: Up to 15 Months

Code: NCT02852031·Recruiting·Listed Aug 2016

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Depression, Aging, Stress and Heart Health Study

for Menopause

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 44 - 55·Accepts healthy volunteers

Code: NCT05570721·Recruiting·Listed Oct 2022

Apply to this trial

GERD in Children With Cystic Fibrosis

for GERD in Children

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 2 - 18

Code: NCT06617013·Recruiting·Listed Sep 2024

Apply to this trial

Vestibular Rehabilitation App for Adults With Dizziness Related to mTBI

for Mild Traumatic Brain Injury

Sites in Durham +2 more locations

Sponsor: Mountain Home Research & Education Corporation

Sex: All·Age: 18+

Code: NCT06222450·Recruiting·Listed Jan 2024

Apply to this trial

Clinical Evaluation of WaveLight Plus LASIK

for Myopia

1 location in Greensboro

Sponsor: Laser Defined Vision

Sex: All·Age: 18+

Code: NCT07127757·Recruiting·Listed Aug 2025

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Comparing Cognitive-Behavioral Therapy Versus Mindfulness-Based Therapy for Autistic Adults

for Autism Spectrum Disorder

Sites in Chapel Hill +1 more location

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT06060860·Recruiting·Listed Sep 2023

Apply to this trial

BREAST Choice Decision Tool R21 - AIM2

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06817226·Recruiting·Listed Feb 2025

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Graded Exposure and Mindfulness Meditation for Patients Post-ACL Reconstruction

for Anterior Cruciate Ligament Injuries

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 14 - 35

Code: NCT05949177·Recruiting·Listed Jul 2023

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APPROVE Trial: Evaluating a Prescription Digital Therapeutic for Treatment of OAB in Women

for Overactive Bladder (OAB)

Sites in Winston-Salem +8 more locations

Sponsor: Medstar Health Research Institute

Sex: Female·Age: 22+

Code: NCT06797245·Recruiting·Listed Jan 2025

Apply to this trial

Beta-Blocker Influences on Inflammatory and Neural Responses to Stress

for Cardiovascular Disease

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 30·Accepts healthy volunteers

Code: NCT06263452·Phase 4·Recruiting·Listed Feb 2024

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Young Adult Infusion Space Experience Satisfaction Survey

for Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 39

Code: NCT05720546·Recruiting·Listed Feb 2023

Apply to this trial

Oxygen Toxicity: Mechanisms in Humans

for Oxygen Toxicity

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05761756·Recruiting·Listed Mar 2023

Apply to this trial

Emovi 3D Knee Assessment Device Intervention for Operational Readiness

for Patellofemoral Pain

Sites in Fort Liberty +1 more location

Sponsor: Womack Army Medical Center

Sex: All·Age: 18 - 50

Code: NCT06517056·Recruiting·Listed Jul 2024

Apply to this trial

Performance and Safety of a Digital Tool for Unsupervised Self-assessment of NMOSD

for Neuromyelitis Optica

Sites in Chapel Hill +9 more locations

Sponsor: Ad scientiam

Sex: All·Age: 18+

Code: NCT05566769·Recruiting·Listed Oct 2022

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Evaluating Hemidiaphragmatic Paralysis With Prolonged Neural Blockade From an Interscalene Brachial Plexus Block

for Shoulder Surgery

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 80

Code: NCT04209504·Recruiting·Listed Dec 2019

Apply to this trial

sTErnAl heMostasiS Trial

for Excessive Bleeding During Surgery

1 location in Raleigh

Sponsor: WakeMed Health and Hospitals

Sex: All·Age: 21+

Code: NCT06511778·Phase 4·Recruiting·Listed Jul 2024

Apply to this trial

COA-APTIC Cognitive Interview Study of Caregiver and Clinician Assessment of Acute Pain in Infants and Young Children

for Acute Pain

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06164028·Recruiting·Listed Dec 2023

Apply to this trial

The EndRAD Trial: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children, Adolescents, and Young Adults With B-ALL

for B-cell Acute Lymphoblastic Leukemia

Sites in Charlotte +23 more locations

Sponsor: Pediatric Transplantation & Cellular Therapy Consortium

Sex: All·Age: 1 - 25

Code: NCT03509961·Phase 2·Recruiting·Listed Apr 2018

Apply to this trial