Paid Clinical Trials in North Carolina

North Carolina has 2,944 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,944 clinical trials

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A Study of Azenosertib (ZN-c3) in Subjects With Platinum-Resistant High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

for High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

44 locations incl. Mobile

Sponsor: K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc

Sex: Female·Age: 18+

Code: NCT05128825·Phase 2·Recruiting

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AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

for Heart Failure

37 locations incl. Fairhope

Sponsor: Cordio Medical

Sex: All·Age: 22+

Code: NCT06378632·Recruiting

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TReatment for ImmUne Mediated PathopHysiology

for Acute Liver Failure

24 locations incl. Los Angeles

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 1 - 18

Code: NCT04862221·Phase 2·Recruiting

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Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps

for Adenocarcinoma of the Colon

472 locations incl. Fairbanks

Sponsor: NRG Oncology

Sex: All·Age: 45 - 70

Code: NCT05080673·Recruiting

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Assessment of CCM in HF With Higher Ejection Fraction

for Heart Failure

105 locations incl. Birmingham

Sponsor: Impulse Dynamics

Sex: All·Age: 18+

Code: NCT05064709·Recruiting

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A Study to Test the Safety and Tolerability of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures

for Stereotypical Prolonged Seizures

53 locations incl. Phoenix

Sponsor: UCB Biopharma SRL

Sex: All·Age: 12+

Code: NCT05076617·Phase 3·Enrolling By Invitation

Safety and Efficacy Study of PF-06835375 in Primary Immune Thrombocytopenia

for Primary Immune Thrombocytopenia

1 location in Greenville

Sponsor: Pfizer

Sex: All·Age: 18 - 70

Code: NCT05070845·Phase 2·Recruiting

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Post Approval Study2: Hintermann Series H3 Total Ankle Replacement System

for Osteoarthritis Ankle

10 locations incl. Mission Hills

Sponsor: DT MedTech, LLC

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT04770870·Recruiting

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A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors

for HER2-positive Advanced Solid Tumor

Drug: DB-1303/BNT323

35 locations incl. Cerritos

Sponsor: DualityBio Inc.

Sex: All·Age: 18+

Code: NCT05150691·Phase 1, Phase 2·Recruiting

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CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

for Diffuse Midline Glioma, H3 K27-Altered

34 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 12 Months - 21

Code: NCT04870944·Phase 1, Phase 2·Recruiting

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Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers

for Advanced Solid Tumor

27 locations incl. Tucson

Sponsor: Synthekine

Sex: All·Age: 18+

Code: NCT05098132·Phase 1, Phase 2·Recruiting

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Open Versus Arthroscopic Stabilization of Shoulder Instability With Subcritical Bone Loss: The OASIS Trial

for Shoulder Dislocation

15 locations incl. Tempe

Sponsor: University of Pittsburgh

Sex: All·Age: 17 - 50

Code: NCT04809064·Recruiting

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Virtual Reality Visual Field Testing as an Alternative in Childhood Eye Disease

for Visual Field Defect, Peripheral

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 4 - 21·Accepts healthy volunteers

Code: NCT05150197·Recruiting

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Long-term Extension Study to Assess Safety and Tolerability of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Pediatric Participants (Ages 6-17)

for Migraine

Drug: Ubrogepant

109 locations incl. Huntsville

Sponsor: AbbVie

Sex: All·Age: 6 - 17

Code: NCT05127954·Phase 3·Enrolling By Invitation

Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)

for Migraine

Drug: Ubrogepant

125 locations incl. Huntsville

Sponsor: AbbVie

Sex: All·Age: 6 - 17

Code: NCT05125302·Phase 3·Recruiting

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Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD

for AMD

107 locations incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: 50 - 89

Code: NCT05407636·Phase 3·Recruiting

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Myriad™ Augmented Soft Tissue Reconstruction Registry

for Abdominal Wound Dehiscence

13 locations incl. Los Angeles

Sponsor: Aroa Biosurgery Limited

Sex: All·Age: 18+

Code: NCT05243966·Recruiting

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Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma

for Lymphoplasmacytic Lymphoma

Drug: Venetoclax

133 locations incl. Tucson

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04840602·Phase 2·Recruiting

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Proact: A Study of REACT in Subjects With Type 2 Diabetes Mellitus and Chronic Kidney Disease

for Type 2 Diabetes Mellitus

79 locations incl. Huntsville

Sponsor: Prokidney

Sex: All·Age: 30 - 80

Code: NCT05099770·Phase 3·Recruiting

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Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II

for Refractory Angina

70 locations incl. Phoenix

Sponsor: Shockwave Medical, Inc.

Sex: All·Age: 18+

Code: NCT05102019·Recruiting

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A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

for Locally Advanced Solid Tumor

20 locations incl. Orange

Sponsor: Nuvalent Inc.

Sex: All·Age: 12+

Code: NCT05118789·Phase 1, Phase 2·Recruiting

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HALOS: A Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Multiple Ascending Doses of ION582 in Participants With Angelman Syndrome

for Angelman Syndrome

6 locations incl. San Diego

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 0 - 50

Code: NCT05127226·Phase 1, Phase 2·Recruiting

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UNC Childhood, Adolescent, and Young Adult Cancer Cohort

for Pediatric Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 1 - 39

Code: NCT05096923·Recruiting

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ViTAA Registry Pre- and Post-Operative Monitoring for Endovascular Aortic Aneurysm Repair and Serial Monitoring for AAA

for Abdominal Aortic Aneurysms

4 locations incl. Birmingham

Sponsor: ViTAA Medical Solutions

Sex: All·Age: 18+

Code: NCT05004051·Recruiting

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Long-term Follow-up Study for Participants of Kite-Sponsored Interventional Studies Treated With Gene-Modified Cells

for Solid and Hematological Malignancies

49 locations incl. Gilbert

Sponsor: Kite, A Gilead Company

Sex: All·Age: All ages

Code: NCT05041309·Enrolling By Invitation

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

for Neovascular Age-related Macular Degeneration

Drug: Ranibizumab

51 locations incl. Mesa

Sponsor: Genentech, Inc.

Sex: All·Age: 50+

Code: NCT04853251·Phase 4·Recruiting

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Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors

for Renal Cell Carcinoma (RCC)

46 locations incl. Phoenix

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT05176483·Phase 1·Recruiting

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JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC

for Carcinoma, Squamous Cell

26 locations incl. Birmingham

Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All·Age: 60+

Code: NCT04892173·Phase 3·Recruiting

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Study of ONO-4685 in Patients With Relapsed or Refractory T Cell Lymphoma

for Relapsed or Refractory T Cell Lymphoma

20 locations incl. Birmingham

Sponsor: Ono Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT05079282·Phase 1·Recruiting

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Prospective Case Collection Study for New Mammography Technologies

for Mammography

15 locations incl. Gilbert

Sponsor: Hologic, Inc.

Sex: Female·Age: 35 - 100·Accepts healthy volunteers

Code: NCT05199701·Recruiting

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4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration

for Neovascular (Wet) Age-Related Macular Degeneration

24 locations incl. Phoenix

Sponsor: 4D Molecular Therapeutics

Sex: All·Age: 50+

Code: NCT05197270·Phase 1, Phase 2·Recruiting

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X-ray Psoralen Activated Cancer Therapy in Head and Neck, Breast, Sarcoma and Melanoma

for Advanced Solid Tumor Cancer

4 locations incl. Washington D.C.

Sponsor: Immunolight, LLC

Sex: All·Age: 18+

Code: NCT04389281·Phase 1·Recruiting

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Hearing Impairment, Strategies and Outcomes in VA Emergency Departments

for Hearing Loss

6 locations incl. Aurora

Sponsor: VA Office of Research and Development

Sex: All·Age: 60+

Code: NCT05028972·Recruiting

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A Study to Test the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures

for Stereotypical Prolonged Seizures

66 locations incl. Phoenix

Sponsor: UCB Biopharma SRL

Sex: All·Age: 12+

Code: NCT05077904·Phase 3·Recruiting

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A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine

for Migraine

20 locations incl. New Haven

Sponsor: H. Lundbeck A/S

Sex: All·Age: 6 - 17

Code: NCT05164172·Phase 3·Recruiting

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Pediatric Post-Approval Registry

for Obstructive Sleep Apnea

8 locations incl. Aurora

Sponsor: Inspire Medical Systems, Inc.

Sex: All·Age: 18 - 21

Code: NCT04457154·Recruiting

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(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis

for Indolent Systemic Mastocytosis

14 locations incl. Birmingham

Sponsor: Blueprint Medicines Corporation

Sex: All·Age: 18+

Code: NCT04910685·Phase 2, Phase 3·Recruiting

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A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With REGN5678 for Adult Participants With Advanced Prostate Cancer

for Metastatic Castration-resistant Prostate Cancer

14 locations incl. Palo Alto

Sponsor: Regeneron Pharmaceuticals

Sex: Male·Age: 18+

Code: NCT05125016·Phase 1, Phase 2·Recruiting

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Development & Validation of Preoperative Objective Physiological Evaluation

for Cardiorespiratory Fitness

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT05092126·Recruiting

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CLN-049 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)

for Relapsed/Refractory Acute Myeloid Leukemia (AML)

11 locations incl. Birmingham

Sponsor: Cullinan Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT05143996·Phase 1·Recruiting

Apply to this trial