Paid Clinical Trials in North Carolina

North Carolina has 2,804 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,435 clinical trials

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Product Surveillance Registry

for Cardiac Rhythm Disorders

Sites in Durham, Chapel Hill +127 more locations

Sponsor: Medtronic

Sex: All·Age: All ages

Code: NCT01524276·Recruiting·Listed Feb 2012

Apply to this trial

Robotic OCT for ER Anterior Eye Exams

for Develop and Test Robotically Assisted Imaging System for the Front of the Eye

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06566339·Recruiting·Listed Aug 2024

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Study to Assess Real-world Effectiveness of Belimumab for Treatment of Adults With LN

for Lupus Nephritis

Sites in Charlotte +3 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT06527872·Recruiting·Listed Jul 2024

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Safety and Performance of the OTTAVA System in Participants Undergoing Inguinal Hernia Repair

for Hernia, Inguinal

Sites in Durham +3 more locations

Sponsor: Auris Health, Inc.

Sex: All·Age: 22+

Code: NCT07298317·Recruiting·Listed Dec 2025

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Dose-Ranging Safety, Tolerability, and Efficacy Study of AZD2373 in Participants With APOL1-Mediated Kidney Disease

for APOL1-Mediated Kidney Disease

Sites in Durham, Winston-Salem +76 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 65

Code: NCT06824987·Phase 2·Recruiting·Listed Feb 2025

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A Long-term Treatment Extension Study of Niraparib in Participants Who Completed a Prior GlaxoSmithKline/TESARO-sponsored Niraparib Study

for Ovarian Neoplasms

Drug: Niraparib

Sites in Charlotte +8 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT04641247·Phase 2·Recruiting·Listed Nov 2020

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Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS

for Acute Coronary Syndrome

Sites in Winston-Salem, Rocky Mount +146 more locations

Sponsor: DalCor Pharmaceuticals

Sex: All·Age: 45+

Code: NCT05918861·Phase 3·Recruiting·Listed Jun 2023

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Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation

for Delayed Graft Function

Sites in Durham +29 more locations

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06830798·Phase 3·Recruiting·Listed Feb 2025

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Global Trial in APG2575 for Patients With CLL/SLL

for CLL/SLL

Sites in Greenville +10 more locations

Sponsor: Ascentage Pharma Group Inc.

Sex: All·Age: 18 - 99

Code: NCT06104566·Phase 3·Recruiting·Listed Oct 2023

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First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors

for Solid Tumor, Adult

Sites in Huntersville +8 more locations

Sponsor: DualityBio Inc.

Sex: All·Age: 18+

Code: NCT06554795·Phase 1, Phase 2·Recruiting·Listed Aug 2024

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A Study to Investigate OCS Tapering in Adult Participants With Generalized Myasthenia Gravis Treated With Ravulizumab

for Generalized Myasthenia Gravis

Sites in Raleigh +4 more locations

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07221838·Phase 4·Recruiting·Listed Oct 2025

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A Study on the Immune Response and Safety of an Investigational Chickenpox Vaccine When Given to Healthy Children 12 to 15 Months of Age

for Chickenpox

Sites in Charlotte +49 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 12 Months - 15 Months·Accepts healthy volunteers

Code: NCT06740630·Phase 3·Recruiting·Listed Dec 2024

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A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)

for Head and Neck Squamous Cell Carcinoma

Drug: Petosemtamab

Sites in Durham, Winston-Salem +34 more locations

Sponsor: Merus B.V.

Sex: All·Age: 18+

Code: NCT06525220·Phase 3·Recruiting·Listed Jul 2024

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A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)

for Polymyositis, Dermatomyositis

Sites in Durham, Charlotte +32 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 75

Code: NCT06455449·Phase 3·Recruiting·Listed Jun 2024

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A Trial to Evaluate the Efficacy and Safety of Ninerafaxstat in Patients With Symptomatic Non-obstructive Hypertrophic Cardiomyopathy

for Non-obstructive Hypertrophic Cardiomyopathy

Sites in Charlotte +21 more locations

Sponsor: Imbria Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07023614·Phase 2·Recruiting·Listed Jun 2025

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A Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis

for Pulmonary Sarcoidosis

Sites in Greenville +13 more locations

Sponsor: Xentria, Inc.

Sex: All·Age: 18 - 80

Code: NCT05890729·Phase 1, Phase 2·Recruiting·Listed Jun 2023

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A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)

for Multiple Myeloma

Drug: Belantamab mafodotin

Sites in Winston-Salem, Charlotte +28 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT06679101·Phase 3·Recruiting·Listed Nov 2024

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Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)

for Pulmonary Disease, Chronic Obstructive

Drug: Depemokimab

Sites in Shelby +54 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 40 - 80

Code: NCT06961214·Phase 3·Recruiting·Listed May 2025

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A Study of Azenosertib (ZN-c3) in Patients With Ovarian Cancer

for Solid Tumor

Sites in Durham +6 more locations

Sponsor: K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc

Sex: Female·Age: 18+

Code: NCT04516447·Phase 1·Recruiting·Listed Aug 2020

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Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension

for Hypertension

Sites in Kinston +27 more locations

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 18 - 65

Code: NCT07090161·Phase 2·Recruiting·Listed Jul 2025

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Open-label Extension Study in Participants With Early Alzheimer's Disease

for Alzheimer's Disease

Sites in Matthews +8 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 50 - 85

Code: NCT07105709·Phase 2·Recruiting·Listed Aug 2025

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Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS)

for Acute Respiratory Distress Syndrome

Sites in Durham, Winston-Salem +30 more locations

Sponsor: Direct Biologics, LLC

Sex: All·Age: 18 - 75

Code: NCT05354141·Phase 3·Recruiting·Listed Apr 2022

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Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer

for Colonic Neoplasms

Drug: Dostarlimab

Sites in Durham +26 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT05855200·Phase 3·Recruiting·Listed May 2023

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An Eight-Week Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye

for Dry Eye

Sites in Shelby +4 more locations

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07179055·Phase 2·Recruiting·Listed Sep 2025

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A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

for Triple Negative Breast Cancer

Sites in Huntersville +9 more locations

Sponsor: Dren Bio

Sex: All·Age: 18+

Code: NCT06999187·Phase 1·Recruiting·Listed May 2025

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Study of ALTO-300 in MDD

for Major Depressive Disorder

Sites in Hickory +37 more locations

Sponsor: Alto Neuroscience

Sex: All·Age: 18 - 70

Code: NCT05922878·Phase 2·Recruiting·Listed Jun 2023

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A Study to Evaluate the Safety and Efficacy of NEXAGON® (Lufepirsen Ophthalmic Gel) in Subjects With PCED

for Persistent Corneal Epithelial Defect

Sites in Shelby +20 more locations

Sponsor: Glaukos Corporation

Sex: All·Age: 2+

Code: NCT05966493·Phase 2·Recruiting·Listed Jul 2023

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A Phase 2a Proof of Concept Open-Label, Randomized, Controlled Study to Evaluate the Safety and Efficacy of MDI-1228-mesylate Gel Compared With Standard of Care Alone in Patients With Diabetic Foot Ulcers

for Diabetic Foot Ulcer

1 location in Durham

Sponsor: Zhuhai Rui-Inno Pharmaceutical Technology Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT06852976·Phase 2·Recruiting·Listed Feb 2025

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A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

for Major Depressive Disorder

Sites in Hickory +39 more locations

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT06223880·Phase 4·Recruiting·Listed Jan 2024

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