Paid Clinical Trials in Orange, CA

As of August 2026, 507 paid clinical trials are recruiting in Orange, California. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 10, 2026.

Filter results

Filter results

State

City

Facility

Recruitment status

Phase

Study type

Intervention

Condition

Sex

Age

Healthy volunteers only

469 clinical trials

AS-1763 in Patients With Previously Treated CLL/SLL or Non-Hodgkin Lymphoma

for B-cell Malignancy

Sites in Orange +12 more locations

Sponsor: Carna Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT05602363·Phase 1·Recruiting·Listed Nov 2022

Apply to this trial

A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

for Locally Advanced Solid Tumor

Sites in Orange, Palo Alto +17 more locations

Sponsor: Nuvalent Inc.

Sex: All·Age: 12+

Code: NCT05118789·Phase 1, Phase 2·Recruiting·Listed Nov 2021

Apply to this trial

Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

for Major Depressive Disorder

Drug: NBI-1065845

Sites in Orange, Pico Rivera +11 more locations

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18+

Code: NCT06786624·Phase 3·Recruiting·Listed Jan 2025

Apply to this trial

A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab

for Ovarian Cancer

Drug: Cemiplimab

Sites in Orange, Irvine +10 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT04590326·Phase 1, Phase 2·Recruiting·Listed Oct 2020

Apply to this trial

Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Acute Femoropopliteal DVT

for Thrombosis, Deep Vein

Sites in Orange +12 more locations

Sponsor: Mercator MedSystems, Inc.

Sex: All·Age: 18 - 89

Code: NCT04862468·Phase 2·Recruiting·Listed Apr 2021

Apply to this trial

A Long-Term Observational Study of Patients With Fucosidosis

for Fucosidosis

Sites in Orange +1 more location

Sponsor: JCR Pharmaceuticals Co., Ltd.

Sex: All·Age: All ages

Code: NCT07615400·Recruiting·Listed May 2026

Apply to this trial

Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies

for AML (Acute Myeloid Leukemia)

Sites in Orange +1 more location

Sponsor: Rigel Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07486713·Phase 4·Recruiting·Listed Mar 2026

Apply to this trial

A Safety and Efficacy Study of EIK1001 in Combination With Pembrolizumab and Chemotherapy in Participants With Stage 4 Non-Small Cell Lung Cancer.

for Non Small Cell Lung Cancer (Squamous or Non Squamous)

Sites in Orange, Glendale +10 more locations

Sponsor: Eikon Therapeutics

Sex: All·Age: 18+

Code: NCT07365319·Phase 2, Phase 3·Recruiting·Listed Jan 2026

Apply to this trial

A Clinical Study to Evaluate the Effects of NXT007 Compared to Emicizumab Prophylaxis in People With Hemophilia A

for Hemophilia A

Drug: NXT007

Sites in Orange +5 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 12+

Code: NCT07416604·Phase 3·Recruiting·Listed Feb 2026

Apply to this trial

HMPL-A580 in Participants With Advanced or Metastatic Solid Tumor

for Solid Tumors, Adult

Drug: HMPL-A580

Sites in Orange +4 more locations

Sponsor: Hutchmed

Sex: All·Age: 18+

Code: NCT07396584·Phase 1, Phase 2·Recruiting·Listed Feb 2026

Apply to this trial

A Study to Investigate the Efficacy and Safety of Fitusiran Prophylaxis in Male Participants Aged 1 to Less Than 12 Years With Hemophilia A or B

for Hemophilia

Sites in Orange, Los Angeles +3 more locations

Sponsor: Sanofi

Sex: Male·Age: 1 - 11

Code: NCT07285460·Phase 3·Recruiting·Listed Dec 2025

Apply to this trial

A Gene Therapy Study of SPK-8011QQ in Adults With Severe or Moderately Severe Hemophilia A

for Hemophilia A

Sites in Orange, Vallejo & San Francisco

Sponsor: Hoffmann-La Roche

Sex: Male·Age: 18+

Code: NCT07226206·Phase 1, Phase 2·Recruiting·Listed Nov 2025

Apply to this trial

Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)

for Sickle Cell Disease

Drug: Anumigilimab

Sites in Orange +8 more locations

Sponsor: CSL Behring

Sex: All·Age: 18+

Code: NCT07224360·Phase 2·Recruiting·Listed Nov 2025

Apply to this trial

A Phase 1/2a, First-in-human, Study of BMS-986517 in Participants With Advanced Solid Tumors

for Solid Tumours

Drug: BMS-986517

Sites in Orange, Irvine +7 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07160725·Phase 1, Phase 2·Recruiting·Listed Sep 2025

Apply to this trial

A Study of Gilteritinib in Adults With Advanced ALK-positive Non-small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer (NSCLC)

Sites in Orange, Fullerton +7 more locations

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 18+

Code: NCT07140016·Phase 1·Recruiting·Listed Aug 2025

Apply to this trial

A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)

for Esophageal Squamous Cell Carcinoma

Sites in Orange, Fullerton +11 more locations

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06644781·Phase 3·Recruiting·Listed Oct 2024

Apply to this trial

Phase 3, Open-label, Single-dose Study of CSL222 in Adolescent Male Subjects (≥ 12 to < 18 Years of Age) With Severe or Moderately Severe Hemophilia B

for Hemophilia B

Sites in Orange +4 more locations

Sponsor: CSL Behring

Sex: Male·Age: 138 Months - 206 Months

Code: NCT07080905·Phase 3·Recruiting·Listed Jul 2025

Apply to this trial

A Study of Gammagard Liquid (Immune Globulin Infusion, 10%) to Prevent Infections in Adults With Multiple Myeloma

for Multiple Myeloma

Sites in Orange +6 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06980480·Phase 3·Recruiting·Listed May 2025

Apply to this trial

A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer

for Breast Cancer

Sites in Orange, Los Angeles +2 more locations

Sponsor: Hoffmann-La Roche

Sex: Female·Age: 18+

Code: NCT07054190·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

Glycogen Storage Disease Type Ia (GSDIa) Disease Monitoring Program

for Glycogen Storage Disease Type Ia

Sites in Orange +8 more locations

Sponsor: Ultragenyx Pharmaceutical Inc

Sex: All·Age: 2+

Code: NCT06636383·Recruiting·Listed Oct 2024

Apply to this trial

A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)

for Castration-Resistant Prostatic Cancer

Sites in Orange, Los Angeles +7 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06863272·Phase 1, Phase 2·Recruiting·Listed Mar 2025

Apply to this trial

An Observational Extension Study for Adult Patients Treated in Study R5459-RT-1944 Who Receive a Kidney Transplant

for Chronic Kidney Disease (CKD)

Sites in Orange, Los Angeles +5 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18 - 70

Code: NCT05106387·Recruiting·Listed Nov 2021

Apply to this trial

Study to Evaluate IMGS-001 Treatment in Patients With Relapsed or Refractory Advanced Solid Tumors

for Solid Tumor

Sites in Orange, Santa Monica +9 more locations

Sponsor: ImmunoGenesis

Sex: All·Age: 18+

Code: NCT06014502·Phase 1·Recruiting·Listed Aug 2023

Apply to this trial

Study to Evaluate Safety and Efficacy of Different PANZYGA Dose Regimens in Pediatric Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) Patients

for Pediatric Chronic Inflammatory Demyelinating Polyneuropathy

Sites in Orange +5 more locations

Sponsor: Octapharma

Sex: All·Age: 2 - 17

Code: NCT04929236·Phase 3·Recruiting·Listed Jun 2021

Apply to this trial

A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of INV-9956 in Adult Patients With Advanced Metastatic Castration Resistant Prostate Cancer

for Advanced Metastatic Castration Resistant Prostate Cancer

Sites in Orange, Newport Beach +5 more locations

Sponsor: Shenzhen Ionova Life Sciences Co., Ltd.

Sex: Male·Age: 18+

Code: NCT06609005·Phase 1, Phase 2·Recruiting·Listed Sep 2024

Apply to this trial

Mucopolysaccharidosis VII Disease Monitoring Program

for Mucopolysaccharidosis VII

Sites in Orange +5 more locations

Sponsor: Ultragenyx Pharmaceutical Inc

Sex: All·Age: All ages

Code: NCT03604835·Recruiting·Listed Jul 2018

Apply to this trial

ET140203 T Cells in Pediatric Subjects With Hepatoblastoma, HCN-NOS, or Hepatocellular Carcinoma

for Hepatoblastoma

Sites in Orange, Los Angeles +2 more locations

Sponsor: Eureka Therapeutics Inc.

Sex: All·Age: 1 - 21

Code: NCT04634357·Phase 1, Phase 2·Recruiting·Listed Nov 2020

Apply to this trial

Study to Assess Safety, Efficacy, and Cellular Kinetics of YTB323 in Generalized Myasthenia Gravis

for Generalized Myasthenia Gravis

Sites in Orange +3 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 65

Code: NCT06704269·Phase 1, Phase 2·Recruiting·Listed Nov 2024

Apply to this trial

AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor

for Ventricular Ejection Fraction

Sites in Orange, Pasadena +6 more locations

Sponsor: Peerbridge Health, Inc

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06699056·Recruiting·Listed Nov 2024

Apply to this trial

A Phase 1/2, First-in-Human Study On ODM-212 In Subjects With Selected Advanced Solid Tumours

for Solid Tumours

Sites in Orange, Los Angeles +6 more locations

Sponsor: Orion Corporation, Orion Pharma

Sex: All·Age: 18+

Code: NCT06725758·Phase 1, Phase 2·Recruiting·Listed Dec 2024

Apply to this trial

A Study to Evaluate the Safety and Tolerability of Eravacycline in Pediatric Patients Aged 8 to 17 With Complicated Intra-abdominal Infections (cIAI)

for Complicated Intra-abdominal Infections (cIAI)

Sites in Orange, Los Angeles +3 more locations

Sponsor: Tetraphase Pharmaceuticals, Inc

Sex: All·Age: 8 - 17

Code: NCT06794541·Phase 2·Recruiting·Listed Jan 2025

Apply to this trial

Combination of TATE and PD-1 Inhibitor in Liver Cancer

for Hepatocellular Carcinoma

Sites in Orange +2 more locations

Sponsor: Teclison Ltd.

Sex: All·Age: 18 - 80

Code: NCT03259867·Phase 2·Recruiting·Listed Aug 2017

Apply to this trial

EvaluatioN of Optilume Drug-Coated Balloon for the Endoscopic Treatment of UREteric Strictures

for Ureteral Stricture

Sites in Orange +6 more locations

Sponsor: Urotronic Inc.

Sex: All·Age: 18+

Code: NCT07020520·Recruiting·Listed Jun 2025

Apply to this trial

A Study of VET3-TGI in Patients With Solid Tumors

for Solid Tumor, Adult

Sites in Orange, Los Angeles +5 more locations

Sponsor: KaliVir Immunotherapeutics

Sex: All·Age: 18+

Code: NCT06444815·Phase 1·Recruiting·Listed Jun 2024

Apply to this trial

Study of CTO1681 for the Prevention and Treatment of CRS in DLBCL Patients Receiving CAR T-Cell Therapy

for Cytokine Release Syndrome

Sites in Orange +5 more locations

Sponsor: CytoAgents, Inc.

Sex: All·Age: 18+

Code: NCT05905328·Phase 1, Phase 2·Recruiting·Listed Jun 2023

Apply to this trial

TATE and Pembrolizumab (MK3475) in mCRC and NSCLC

for Colorectal Cancer

1 location in Orange

Sponsor: Teclison Ltd.

Sex: All·Age: 18+

Code: NCT04701476·Phase 2·Recruiting·Listed Jan 2021

Apply to this trial

A Study of D3S-001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.G12C Mutation

for KRAS P.G12C

Sites in Orange, Palo Alto +5 more locations

Sponsor: D3 Bio (Wuxi) Co., Ltd

Sex: All·Age: 18+

Code: NCT05410145·Phase 1, Phase 2·Recruiting·Listed Jun 2022

Apply to this trial

Global Patient Registry to Monitor Long-term Safety and Effectiveness of Increlex® in Children and Adolescents With Severe Primary Insulin-like Growth Factor-1 Deficiency (SPIGFD).

for IGF1 Deficiency

Sites in Orange +4 more locations

Sponsor: Esteve Pharmaceuticals, S.A.

Sex: All·Age: 2 - 18

Code: NCT00903110·Recruiting·Listed May 2009

Apply to this trial

AAV Gene Therapy Clinical Study in Adult Classic PKU (PHEdom)

for Phenylketonurias

Sites in Orange +4 more locations

Sponsor: NGGT INC.

Sex: All·Age: 18 - 55

Code: NCT06332807·Phase 1, Phase 2·Recruiting·Listed Mar 2024

Apply to this trial

A Phase 1/2, Dose-Exploration Study to Evaluate the Safety and Efficacy of BEAM-301 in Patients With Glycogen Storage Disease Type Ia (GSDIa)

for Glycogen Storage Disease Type Ia

Sites in Orange +2 more locations

Sponsor: Beam Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06735755·Phase 1, Phase 2·Recruiting·Listed Dec 2024

Apply to this trial