Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,479 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 4, 2026.

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3,012 clinical trials

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Optimizing Integrative Oncology Approaches to Address Chemotherapy-induced Peripheral Neuropathy in Gastrointestinal (GI) Cancer Patients: A SMART Pilot Study

for Peripheral Neuropathy

1 location in Philadelphia

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT07501663·Recruiting·Listed Mar 2026

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Clinical Trial to Evaluate the Safety and Immunogenicity of the V2 Apex-Directed Immunogens DV201P-RNA and DV202B1-RNA in Adult Participants Without HIV

for HIV

Sites in Philadelphia, Pittsburgh +5 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07390474·Phase 1·Recruiting·Listed Feb 2026

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Flourish in Schools Pilot Study

for Psychological Distress

Sites in Pittsburgh +1 more location

Sponsor: Candice Biernesser

Sex: All·Age: 11 - 21

Code: NCT07506525·Recruiting·Listed Apr 2026

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Pembrolizumab Plus Ultrasound-Induced Microbubble Cavitation in Head and Neck Cancer

for Head and Neck Cancer

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT07501650·Phase 1·Recruiting·Listed Mar 2026

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A Study of Targeted Post-Surgery Radiation Therapy for Non-Small Cell Lung Cancer With Remaining Lymph Node Cancer After Treatment

for Lung Non-Small Cell Carcinoma

Sites in Pittsburgh, Erie +95 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT07293247·Phase 2·Recruiting·Listed Dec 2025

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Kidney Transplant Improvement Through New Exercise Training to Increase Capacity

for Chronic Kidney Disease 5D

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 60+

Code: NCT07446296·Recruiting·Listed Mar 2026

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Testing the Effect of Teclistamab on Recurrent Plasmablastic Lymphoma

for Recurrent Plasmablastic Lymphoma

Drug: Teclistamab

Sites in Pittsburgh +4 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07332507·Phase 1·Recruiting·Listed Jan 2026

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PopSci CHW4CervixHealth

for Cervical Cancer

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: Female·Age: 25 - 65·Accepts healthy volunteers

Code: NCT07336134·Recruiting·Listed Jan 2026

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Click & Pick Study

for Chronic Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07422922·Recruiting·Listed Feb 2026

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Stimulation-Based Modulation of Spinal and Cortical Sensory Pathways

for Stroke

1 location in Pittsburgh

Sponsor: Peter C. Gerszten, MD

Sex: All·Age: 21 - 75·Accepts healthy volunteers

Code: NCT07401186·Recruiting·Listed Feb 2026

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Mental Health Clinician / Chaplain Collaboration

for Moral Injury

1 location in Pittsburgh

Sponsor: Central Arkansas Veterans Healthcare System

Sex: All·Age: 18 - 80

Code: NCT07579143·Recruiting·Listed May 2026

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Neoadjuvant CADI-05 in Combination With Pembrolizumab for Surgically Resectable Locally Advanced Head and Neck Squamous Cell Carcinomas

for Squamous Cell Carcinoma of Head and Neck

2 locations in Philadelphia

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 18+

Code: NCT07455032·Phase 1·Recruiting·Listed Mar 2026

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EXploring Inflammation and Social deTerminants Study in Breast Cancer Patients

for Breast Cancer

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: Female·Age: 18+

Code: NCT07478016·Recruiting·Listed Mar 2026

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Endotype DIrected Treatment for OSA in Down Syndrome

for Obstructive Sleep Apnea (OSA)

Sites in Philadelphia +4 more locations

Sponsor: University of Arizona

Sex: All·Age: 6+

Code: NCT07280468·Phase 4·Recruiting·Listed Dec 2025

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Malabsorption Blood Test (MBT) to Determine Exocrine Pancreatic Function and Related Quality of Life in Chronic Pancreatitis

for Chronic Pancreatitis

Sites in Pittsburgh +1 more location

Sponsor: Anna Evans Phillips

Sex: All·Age: 18+

Code: NCT07418593·Phase 4·Recruiting·Listed Feb 2026

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Radiotherapy for Refractory Hidradenitis Suppurativa

for Hidradenitis Suppurativa (HS)

Sites in Philadelphia +1 more location

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT07414550·Recruiting·Listed Feb 2026

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Spinal Dural Arteriovenous Fistula International Data and Outcomes Registry

for Spinal Dural Arteriovenous Fistula

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: All ages

Code: NCT07574645·Recruiting·Listed May 2026

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Emergency Department Implementation of the i-STAT Alinity Traumatic Brain Injury Whole Blood Test

for TBI (Traumatic Brain Injury)

1 location in Pittsburgh

Sponsor: Shawn Eagle

Sex: All·Age: 18+

Code: NCT07373509·Recruiting·Listed Jan 2026

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Sleep and Circadian Interventions for College Students at High Risk of Suicide

for Sleep Disturbance

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 25

Code: NCT07346014·Recruiting·Listed Jan 2026

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GUCY2C Prime-Boost Vaccination for Advanced Colorectal and Small Bowel Adenocarcinomas

for Colorectal Cancer

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT07417488·Phase 1·Recruiting·Listed Feb 2026

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Study to Enable New Diagnostics for Pulmonary Microbes in People With CF

for Cystic Fibrosis (CF)

Sites in Philadelphia, Pittsburgh +7 more locations

Sponsor: Chris Goss

Sex: All·Age: 16+

Code: NCT07312734·Recruiting·Listed Dec 2025

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Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

for Advanced Endometrial Carcinoma

Drug: Bevacizumab

Sites in Philadelphia, Pittsburgh +260 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT07198074·Phase 3·Recruiting·Listed Sep 2025

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Testing the Addition of Cemiplimab (REGN2810) to Chemotherapy Treatment Given Prior to Surgery in Patients With Sinonasal Squamous Cell Carcinoma

for Sinonasal Squamous Cell Carcinoma

Drug: Cemiplimab

Sites in Pittsburgh +13 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07281417·Phase 2·Recruiting·Listed Dec 2025

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Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

Sites in Philadelphia, Pittsburgh +1087 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting·Listed May 2023

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Implementation of eHealth Delivery Alternatives for Cancer Genetic Testing for Hereditary Cancer (eREACH3)

for Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07471958·Recruiting·Listed Mar 2026

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Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors

for Malignant Pleural Effusion

1 location in Pittsburgh

Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Sex: All·Age: 18 - 79

Code: NCT07443020·Phase 1·Recruiting·Listed Mar 2026

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MAPT Protocol: Fixation Versus Arthroplasty Surgical Treatments for Early Recovery After HIP Fracture (FASTER-HIP)

for Femoral Neck Fractures

Sites in Allentown +19 more locations

Sponsor: University of Southern California

Sex: All·Age: 60+

Code: NCT07244211·Recruiting·Listed Nov 2025

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Application of Contrast-enhanced Ultrasound in Monitoring Soft Tissue Sarcoma Response to Neoadjuvant Radiotherapy

for Soft Tissue Sarcoma

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT07436364·EARLY_Phase 1·Recruiting·Listed Feb 2026

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Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

for Lung Non-Small Cell Carcinoma

Sites in Philadelphia, Pittsburgh +622 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04267848·Phase 3·Recruiting·Listed Feb 2020

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Hysteroscopy for the Diagnosis and Treatment of Pregnancy of Unknown Location

for Pregnancy of Unknown Location

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 18+

Code: NCT07469605·Recruiting·Listed Mar 2026

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Family Communications After Genetic Testing

for Colon Adenocarcinoma

Sites in Allentown, Bethlehem +308 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07143487·Recruiting·Listed Aug 2025

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Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

for Stage III Colon Cancer

Sites in Philadelphia, Pittsburgh +923 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05174169·Phase 2, Phase 3·Recruiting·Listed Dec 2021

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Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma

for Osteosarcoma

Sites in Hershey +1 more location

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 0 - 50

Code: NCT07321912·Phase 2·Recruiting·Listed Jan 2026

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Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer

for Astrocytoma, IDH-Mutant, Grade 3

Drug: Vorasidenib

Sites in Philadelphia, Pittsburgh +115 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 12+

Code: NCT07215910·Phase 3·Recruiting·Listed Oct 2025

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Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas

for Intracranial Meningioma

Sites in Philadelphia, Pittsburgh +446 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT02523014·Phase 2·Recruiting·Listed Aug 2015

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mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

for Advanced Esophageal Adenocarcinoma

Drug: Nivolumab

Sites in Philadelphia, Allentown +626 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05677490·Phase 3·Recruiting·Listed Jan 2023

Apply to this trial

Self-collection for HPV Testing to Improve Cervical Cancer Prevention (SHIP) Trial (LMI-001-A-S04)

for Cervical Carcinoma

Sites in Philadelphia, Pittsburgh +16 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 25+·Accepts healthy volunteers

Code: NCT07281430·Recruiting·Listed Dec 2025

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Investigating Real-Time Immunotherapy Symptoms Study

for Cancer

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT07280715·Recruiting·Listed Dec 2025

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Bowel Continence Across the Lifespan in People With Spina Bifida

for Spina Bifida

Sites in Philadelphia, Pittsburgh +22 more locations

Sponsor: David Chu

Sex: All·Age: 5+

Code: NCT07390318·Recruiting·Listed Feb 2026

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ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Philadelphia, Pittsburgh +594 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06876714·Phase 3·Recruiting·Listed Mar 2025

Apply to this trial