Cardiology Clinical Trials in Philadelphia, PA

As of July 2026, 67 paid clinical trials are recruiting for Cardiology in Philadelphia, Pennsylvania. Cardiology trials investigate SGLT-2 inhibitors, myosin modulators, lipid-lowering therapies, anti-inflammatory agents, and device-based interventions across heart failure, hypertension, AFib, and coronary artery disease. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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67 clinical trials for Cardiology

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Quantifying New Heart Muscle Cells

for Tetralogy of Fallot With Pulmonary Stenosis

Sites in Philadelphia, Pittsburgh +2 more locations

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 30 Days - 1

Code: NCT06587165·Recruiting·Listed Sep 2024

Apply to this trial

Matching Perfusion and Metabolic Activity in HFpEF

for Heart Failure With Preserved Ejection Fraction

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04913805·Phase 2·Recruiting·Listed Jun 2021

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Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

for Heart Diseases

Sites in Philadelphia, Wynnewood +39 more locations

Sponsor: Weill Medical College of Cornell University

Sex: Female·Age: 18+

Code: NCT04124120·Recruiting·Listed Oct 2019

Apply to this trial

HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

for Heart Failure

Sites in Philadelphia +5 more locations

Sponsor: Northwestern University

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT05873634·Recruiting·Listed May 2023

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Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

for Heart Failure

Sites in Philadelphia +5 more locations

Sponsor: Northwestern University

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT06517186·Recruiting·Listed Jul 2024

Apply to this trial

iTONE Trial (exercIse Training in pulmONary hypertEnsion) Exercise Program for Pediatric PH

for Pulmonary Hypertension

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 8 - 18

Code: NCT05442671·Recruiting·Listed Jul 2022

Apply to this trial

Feasibility of Semaglutide in Advanced Lung Disease

for Obesity

Drug: Semaglutide

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 80

Code: NCT05746039·Phase 1, Phase 2·Recruiting·Listed Feb 2023

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Fontan Fitness Trial

for Single-ventricle

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 10 - 17

Code: NCT06918795·Recruiting·Listed Apr 2025

Apply to this trial

SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial

for Heart Failure With Preserved Ejection Fraction

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05138575·Phase 2·Recruiting·Listed Dec 2021

Apply to this trial

Penn Medicine Healthy Heart

for Hypertension

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 35 - 80

Code: NCT06062394·Recruiting·Listed Oct 2023

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Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

for Cystic Fibrosis (CF)

Sites in Philadelphia +17 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 12+

Code: NCT06837181·Recruiting·Listed Feb 2025

Apply to this trial

His-Bundle Corrective Pacing in Heart Failure

for Right Bundle-Branch Block

Sites in Philadelphia, Wilkes-Barre +12 more locations

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT05265520·Recruiting·Listed Mar 2022

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Left vs Left Randomized Clinical Trial

for Heart Failure

Sites in Philadelphia, Allentown +55 more locations

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting·Listed Dec 2022

Apply to this trial

Prospective Validation of the Novel PVD-B65 Risk Score in Patients With Chronic Lung Disease and Pulmonary Hypertension

for Chronic Lung Disease

1 location in Philadelphia

Sponsor: Temple University

Sex: All·Age: 18 - 99

Code: NCT07151768·Recruiting·Listed Sep 2025

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The Path to Optimal Black Maternal Heart Health: Comparing Two CVD Risk Reduction Interventions (Change of HEART)

for Pregnancy Related

1 location in Philadelphia

Sponsor: Temple University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT05499507·Recruiting·Listed Aug 2022

Apply to this trial

Philly CEAL- DECIDE+ Adaptation

for Disparities

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 35 - 75·Accepts healthy volunteers

Code: NCT06732102·Recruiting·Listed Dec 2024

Apply to this trial

Home-Based Exercise Program Using Mobile Technology After Left Ventricular Assist Device Implantation

for Heart Failure

Sites in Philadelphia +3 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06291922·Recruiting·Listed Mar 2024

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Perioperative Anticoagulant Use for Surgery Evaluation -2 (PAUSE-2) Study Patients Receiving a Direct Oral Anticoagulant (DOACs-Dabigatran, Rivaroxaban, Apixaban or Edoxaban) and Needing Elective High-Bleed-Risk Surgery or an Invasive Procedure

for Atrial Fibrillation (AF)

Sites in Philadelphia +5 more locations

Sponsor: McMaster University

Sex: All·Age: 18+

Code: NCT06957366·Recruiting·Listed May 2025

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Pediatric Pulmonary Hypertension Network (PPHNet) Informatics Registry

for Pulmonary Vascular Disease

Sites in Philadelphia +12 more locations

Sponsor: New York Medical College

Sex: All·Age: 1 Day - 21

Code: NCT02249923·Recruiting·Listed Sep 2014

Apply to this trial

Pulmonary Hypertension Association Registry

for Pulmonary Arterial Hypertension

Sites in Philadelphia, Pittsburgh +50 more locations

Sponsor: Pulmonary Hypertension Association, Inc.

Sex: All·Age: 0+

Code: NCT04071327·Recruiting·Listed Aug 2019

Apply to this trial

Perioperative Anticoagulant Use for Surgery Evaluation -Virtual Visit (PAUSE-Virtual)

for Atrial Fibrillation (AF)

Sites in Philadelphia +3 more locations

Sponsor: McMaster University

Sex: All·Age: 18 - 100

Code: NCT06844227·Recruiting·Listed Feb 2025

Apply to this trial

Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

for Pulmonary Hypertension

Sites in Philadelphia +7 more locations

Sponsor: Insmed Incorporated

Sex: All·Age: 18+

Code: NCT07179380·Phase 3·Recruiting·Listed Sep 2025

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A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event

for Cardiovascular Disease

Sites in Philadelphia, Horsham +294 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07000357·Phase 3·Recruiting·Listed Jun 2025

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Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure

for Chronic Lymphocytic Leukaemia

Sites in Philadelphia +1 more location

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06651970·Phase 4·Recruiting·Listed Oct 2024

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Product Surveillance Registry

for Cardiac Rhythm Disorders

Sites in Philadelphia, Allentown +127 more locations

Sponsor: Medtronic

Sex: All·Age: All ages

Code: NCT01524276·Recruiting·Listed Feb 2012

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Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

for Heart Failure

Drug: Dapagliflozin

Sites in Philadelphia, Horsham +172 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40+

Code: NCT06677060·Phase 3·Recruiting·Listed Nov 2024

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Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

for Arrhythmia

Sites in Philadelphia, Allentown +83 more locations

Sponsor: Medtronic

Sex: All·Age: All ages

Code: NCT00271180·Recruiting·Listed Dec 2005

Apply to this trial

Conditions in Cardiology (Philadelphia, PA)

Heart failure· 23 Cardiovascular disease (general)· 15 Atrial fibrillation· 13 Pulmonary hypertension· 13 Hypertension (high blood pressure)· 12 Coronary artery disease· 7 Peripheral artery disease· 3 Congenital heart disease· 2 Myocardial infarction (heart attack)· 1 Venous thromboembolism· 1