Clinical Trials at Children's Hospital of Philadelphia

As of June 2026, 300 paid clinical trials are recruiting at Children's Hospital of Philadelphia in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 3, 2026.

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300 clinical trials at Children's Hospital of Philadelphia

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A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

for Anaplastic Kidney Wilms Tumor

177 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 30

Code: NCT04322318·Phase 2·Recruiting

Apply to this trial

Child and Adolescent Registry for Participants With Narcolepsy

for Narcolepsy

25 locations incl. Phoenix

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: Up to 17

Code: NCT04899947·Recruiting

Apply to this trial

Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults

for Glioblastoma

14 locations incl. Birmingham

Sponsor: Sabine Mueller, MD, PhD

Sex: All·Age: 6 Months - 25

Code: NCT04323046·Phase 1·Recruiting

Apply to this trial

Outcomes and Health Care Resource Utilization in Pediatric Congenital Heart Disease Patients Undergoing Non-Cardiac Procedures

for Congenital Heart Disease in Children

9 locations incl. Los Angeles

Sponsor: Boston Children's Hospital

Sex: All·Age: Up to 21

Code: NCT04604418·Recruiting

Apply to this trial

ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders

for Hematologic Disorder

71 locations incl. Phoenix

Sponsor: American Thrombosis and Hemostasis Network

Sex: All·Age: All ages

Code: NCT04398628·Recruiting

Apply to this trial

Sleep and Glycemic Control in Type 2 Diabetes Adolescents

for Type 2 Diabetes

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 12 - 20

Code: NCT04213547·Recruiting

Apply to this trial

Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy

for Duchenne Muscular Dystrophy

3 locations incl. Gainesville

Sponsor: University of Florida

Sex: Male·Age: 5 - 62·Accepts healthy volunteers

Code: NCT01484678·Recruiting

Apply to this trial

A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

for Acute Myeloid Leukemia

185 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT04293562·Phase 3·Recruiting

Apply to this trial

Inspiring New Science In Guiding Healthcare in Turner Syndrome Registry

for Turner Syndrome

10 locations incl. Aurora

Sponsor: University of Colorado, Denver

Sex: Female·Age: All ages

Code: NCT05052606·Recruiting

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Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body

for Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion

51 locations incl. Mesa

Sponsor: Bayer

Sex: All·Age: All ages

Code: NCT04142437·Recruiting

Apply to this trial

Orphan Indications for CD19 Redirected Autologous T Cells

for Pediatric and Young Adult Patientswith Hypodiploid or t(17

1 location in Philadelphia

Sponsor: Stephan Grupp MD PhD

Sex: All·Age: 0 - 29

Code: NCT04276870·Phase 2·Recruiting

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A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

for Low Grade Astrocytoma

Drug: Selumetinib

124 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 2 - 21

Code: NCT04166409·Phase 3·Recruiting

Apply to this trial

RH Genotype Matched RBC Transfusions

for Sickle Cells Disease

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 6 Months+

Code: NCT04156893·Phase 1, Phase 2·Recruiting

Apply to this trial

A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer

for Neoplasms

30 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 1 - 39

Code: NCT05999994·Phase 2·Recruiting

Apply to this trial

Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

for B Acute Lymphoblastic Leukemia

203 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 25

Code: NCT03959085·Phase 3·Recruiting

Apply to this trial

Phase 1/2 Study of UCART22 in Patients With Relapsed or Refractory CD22+ B-cell Acute Lymphoblastic Leukemia (BALLI-01)

for B-cell Acute Lymphoblastic Leukemia

14 locations incl. Los Angeles

Sponsor: Cellectis S.A.

Sex: All·Age: 15 - 50

Code: NCT04150497·Phase 1, Phase 2·Recruiting

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Autosomal Dominant Polycystic Kidney Disease (ADPKD) Study

for ADPKD

4 locations incl. Washington D.C.

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: Up to 18

Code: NCT04338048·Recruiting

Apply to this trial

Clinical and Basic Investigations Into Congenital Disorders of Glycosylation

for Congenital Disorders of Glycosylation

12 locations incl. San Diego

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: All ages

Code: NCT04199000·Recruiting

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Treatment of BK Virus Infection With CTL Cells in Immunocompromised Transplant Patients

for BK Polyomavirus

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 5 Weeks - 25

Code: NCT04293042·EARLY_Phase 1·Recruiting

Apply to this trial

Oral Iron in Children With Chronic Kidney Disease

for Chronic Kidney Insufficiency

2 locations incl. New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 1 - 21

Code: NCT03991169·Phase 4·Recruiting

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CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT

for Acute Leukemia

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: Up to 25

Code: NCT03810196·Recruiting

Apply to this trial

Two Dose Levels of Privigen in Pediatric CIDP

for Pediatric Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

9 locations incl. Phoenix

Sponsor: CSL Behring

Sex: All·Age: 2 - 17

Code: NCT03684018·Phase 4·Recruiting

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Studying Health Outcomes After Treatment in Patients With Retinoblastoma

for Retinoblastoma

10 locations incl. Chicago

Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT03932786·Recruiting

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A Long-term Observational Study Evaluating Eteplirsen, Golodirsen, or Casimersen in Routine Clinical Practice

for Duchenne Muscular Dystrophy

20 locations incl. Little Rock

Sponsor: Sarepta Therapeutics, Inc.

Sex: Male·Age: All ages

Code: NCT06606340·Enrolling By Invitation

A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee

for Chondral Defect

12 locations incl. Palo Alto

Sponsor: Vericel Corporation

Sex: All·Age: 10 - 17

Code: NCT03588975·Phase 3·Recruiting

Apply to this trial

Rifampin in CYP24A1-related Hypercalcemia and Hypercalciuria

for Idiopathic Infantile Hypercalcaemia - Severe Form

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 6 Months - 65

Code: NCT03301038·Phase 2·Recruiting

Apply to this trial

CEUS for Blunt Abdominal Trauma in Children

for Trauma Abdomen

2 locations incl. Rochester

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 - 17

Code: NCT03490929·Phase 4·Recruiting

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Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

for Ganglioneuroblastoma

152 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 30

Code: NCT03126916·Phase 3·Recruiting

Apply to this trial

Pencil Beam Scanning in Patients With Renal Tumors

for Renal Tumor

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 - 30

Code: NCT03810651·EARLY_Phase 1·Recruiting

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Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia

for Recurrent B Acute Lymphoblastic Leukemia

156 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 1 - 21

Code: NCT02981628·Phase 2·Recruiting

Apply to this trial

Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

for Childhood Extracranial Germ Cell Tumor

566 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: All ages

Code: NCT03067181·Phase 3·Recruiting

Apply to this trial

Natural History Study of Mitochondrial Myopathy

for Primary Mitochondrial Disease

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 - 100·Accepts healthy volunteers

Code: NCT05250375·Recruiting

Apply to this trial

Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children

for Seizures

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 1 Month - 18

Code: NCT03419260·Recruiting

Apply to this trial

MEASuRE: Metreleptin Effectiveness And Safety Registry

for Generalised Lipodystrophy

16 locations incl. Birmingham

Sponsor: Amryt Pharma

Sex: All·Age: All ages

Code: NCT02325674·Recruiting

Apply to this trial

Prospective Research Rare Kidney Stones (ProRKS)

for Hyperoxaluria

8 locations incl. Birmingham

Sponsor: Mayo Clinic

Sex: All·Age: All ages

Code: NCT02780297·Recruiting

Apply to this trial

National Collaborative to Improve Care of Children With Complex Congenital Heart Disease

for Hypoplastic Left Heart Syndrome (HLHS)

61 locations incl. Birmingham

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: Up to 15 Months

Code: NCT02852031·Recruiting

Apply to this trial

Quality of Pediatric Resuscitation in a Multicenter Collaborative

for Cardiac Arrest

40 locations incl. Los Angeles

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 - 18

Code: NCT02708134·Recruiting

Apply to this trial

Neurocognition in Congenital Central Hypoventilation Syndrome (CCHS)

for Congenital Central Hypoventilation Syndrome

4 locations incl. Los Angeles

Sponsor: Debra Weese-Mayer

Sex: All·Age: 3 - 85

Code: NCT03568669·Recruiting

Apply to this trial

Evaluation of Outcome Metrics in Alexander Disease

for Alexander Disease

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: All ages

Code: NCT02714764·Recruiting

Apply to this trial

Fecal Microbiome Transplant

for Clostridium Difficile

1 location in Philadelphia

Sponsor: Judith Kelsen

Sex: All·Age: 3 - 21

Code: NCT02636517·Phase 1·Enrolling By Invitation