Clinical Trials at University of Pennsylvania

As of July 2026, 317 paid clinical trials are recruiting at University of Pennsylvania, located at Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, phone (215) 898-8001 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 1, 2026.

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317 clinical trials at University of Pennsylvania

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The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers

for Smoking

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06264154·Recruiting

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TumorGlow Intraoperative Molecular Imaging (IMI)

for Tumor, Solid

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04723810·Phase 1, Phase 2·Recruiting

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Home-Based Exercise Program Using Mobile Technology After Left Ventricular Assist Device Implantation

for Heart Failure

4 locations incl. Detroit

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06291922·Recruiting

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Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia

for Stroke

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 85

Code: NCT06968663·Phase 2·Recruiting

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FAPI-74 PET/CT in Adults With Fibrosis

for Fibrosis (Morphologic Abnormality)

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 21+

Code: NCT06413355·Phase 1·Recruiting

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tACS to Enhance Language Abilities

for Stroke

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT06092814·Recruiting

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Integrating Telehealth to Advance Lung Cancer Screening

for Early Detection of Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 50 - 80

Code: NCT06638554·Recruiting

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Sildenafil for Microvasculopathy in Chronic TBI

for Traumatic Brain Injury

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 70

Code: NCT05782244·Phase 2·Recruiting

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Exploration of Personalized Biomarkers During Neoadjuvant Radiation Therapy for Spinal and Sacral Chordoma

for Chordoma of Spine

2 locations incl. Baltimore

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All·Age: 18+

Code: NCT06463262·Recruiting

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APPLE: Aspirin to Prevent Pregnancy Loss and Preeclampsia

for Pre-Eclampsia

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 18 - 45

Code: NCT06408181·Phase 3·Recruiting

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Testing LiverWatch, a Home-Based Remote-Monitoring Intervention for Advanced Liver Disease

for Cirrhosis, Liver

2 locations incl. Ann Arbor

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06136221·Recruiting

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MicroRNAs as Biomarkers for Obstructive Sleep Apnea

for Obstructive Sleep Apnea

2 locations incl. Columbus

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 75

Code: NCT06189755·Recruiting

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Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial]

for Lymphedema of the Head and Neck

2 locations incl. Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06125743·Recruiting

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Text-Messaging Telehealth and Contingency Management for Opioid Use Disorder Treatment Engagement

for Opioid Use Disorder

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05897788·Recruiting

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CD33KO-HSPC Infusion Followed by CART-33 Infusion(s) for Refractory/Relapsed AML

for Leukemia, Myeloid, Acute

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05945849·Phase 1·Recruiting

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SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation

for Acute Myeloid Leukemia With FLT3/ITD Mutation

4 locations incl. Chapel Hill

Sponsor: Uma Borate

Sex: All·Age: 18+

Code: NCT06222580·Phase 1·Recruiting

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Study of Biodistribution, Metabolism, Excretion and Brain Uptake11C-M503

for Tauopathies

3 locations incl. New Haven

Sponsor: University of Pennsylvania

Sex: All·Age: 40 - 85·Accepts healthy volunteers

Code: NCT06303921·EARLY_Phase 1·Recruiting

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Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia

for Primary Progressive Aphasia

2 locations incl. Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 50 - 90·Accepts healthy volunteers

Code: NCT05386394·Phase 2·Recruiting

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Prostate Tissue BioBank

for Prostate Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: Male·Age: 18+

Code: NCT06659614·Recruiting

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Transforming Hemodialysis-Related Vascular Access Education

for Chronic Kidney Disease

3 locations incl. Baltimore

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05997875·Recruiting

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TmCD19-IL18 in CD19+ Cancers

for Non Hodgkin Lymphoma

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05989204·Phase 1·Recruiting

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Integrating Brain, Neurocognitive, and Computational Tools in OUD

for Opioid Use Disorder

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 60

Code: NCT06136247·Recruiting

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Early Longitudinal Imaging in the Parkinson's Progressive Marker Initiative (PPMI) Using (18F)AV-133 (PPMI AV-133 Prodromal Imaging)

for Prodromal Parkinsons Disease

2 locations incl. New Haven

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 18+

Code: NCT07265596·Phase 2·Recruiting

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FES BPET-DBT in Newly Diagnosed Breast Cancer

for Breast Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: Female·Age: 18+

Code: NCT05659797·EARLY_Phase 1·Recruiting

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A Study to Investigate Why Overweight People Regain Weight After Losing Weight in a Behavioral Weight Loss Program

for Obesity

3 locations incl. New York

Sponsor: University of Pittsburgh

Sex: All·Age: 25 - 59

Code: NCT05748158·Recruiting

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Strategies to Close the Gap From Cervical Cancer Diagnosis to Treatment in Botswana

for Cervical Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: Female·Age: 18+

Code: NCT05952141·Recruiting

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Study of Biodistribution, Metabolism, Excretion and Brain Uptake of 11C-HY-2-15

for Tauopathies

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 40 - 80·Accepts healthy volunteers

Code: NCT06032026·EARLY_Phase 1·Recruiting

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CW2IP2: Imaging and Diagnostic Assessments

for Tauopathies

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 40 - 85·Accepts healthy volunteers

Code: NCT06083467·Recruiting

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Human Learning of New Structured Information Across Time and Sleep

for Learning

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 35·Accepts healthy volunteers

Code: NCT05910762·Recruiting

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Phase IB/II of CPX-351 for Relapse Prevention in AML

for Acute Myeloid Leukemia (AML) in Remission

3 locations incl. Washington D.C.

Sponsor: Georgetown University

Sex: All·Age: 18+

Code: NCT04990102·Phase 1, Phase 2·Recruiting

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Cannabis Use and Outcomes in Black and White Patients With Cancer

for Cancer

3 locations incl. Buffalo

Sponsor: State University of New York at Buffalo

Sex: All·Age: 21 - 99

Code: NCT06037681·Recruiting

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Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)

for Alzheimer's Disease

2 locations incl. Boston

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 120

Code: NCT05658913·Recruiting

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Reducing Patient Memory Recall in the Burning Mouth Patient Population

for Burning Mouth Syndrome

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05819697·Recruiting

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Longitudinal Study for Central Nervous System Vasculitis

for Central Nervous System Vasculitis

4 locations incl. Rochester

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05734404·Recruiting

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Decoding and Modulating Affective Brain States

for Rumination

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 65

Code: NCT05437705·Recruiting

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Effect of CPAP on Blood Pressure in Excessively Sleepy Obstructive Sleep Apnea Subtype

for Obstructive Sleep Apnea

2 locations incl. Columbus

Sponsor: Ohio State University

Sex: All·Age: 18 - 75

Code: NCT05742360·Recruiting

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Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension; Renewal

for Liver Diseases

2 locations incl. Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT05470205·Phase 3·Recruiting

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Resting State Changes Following Theta Burst Stimulation

for Brain Connectivity

1 location in Philadelphia

Sponsor: Nicholas Balderston, PhD

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT05322239·Recruiting

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All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma

for Glioma

1 location in Philadelphia

Sponsor: Stephen Bagley, MD, MSCE

Sex: All·Age: 18+

Code: NCT05345002·Phase 2·Recruiting

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LCAT (Lecithin Cholesterol Acyl Transferase) Natural History Study

for LCAT Deficiency

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT06217588·Recruiting

Apply to this trial