Clinical Trials at University of Pennsylvania

As of July 2026, 317 paid clinical trials are recruiting at University of Pennsylvania, located at Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, phone (215) 898-8001 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 1, 2026.

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317 clinical trials at University of Pennsylvania

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How Hormones and Exposure and Response Prevention (EX/RP) Affect the Brain of People With OCD

for OCD

2 locations incl. New York

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 45

Code: NCT05359562·Recruiting

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The PIVATAL Study -Study of Ventricular Arrhythmia (VTA) Ablation in Left Ventricular Assist Device (LVAD) Patients

for Arrythmia

19 locations incl. Phoenix

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT05034432·Phase 4·Recruiting

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Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women to Assess the Safety of Prevention - US Cohort Study

for Ovarian Cancer

9 locations incl. Boston

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT05287451·Recruiting

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Tadekinig Alfa (IL-18BP) Rescue Therapy for CAR T Cell Related Cytokine Release Syndrome (CRS) and HLH-like Syndrome

for CRS - Cytokine Release Syndrome

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05306080·EARLY_Phase 1·Recruiting

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Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology

for Semantic Dementia

5 locations incl. San Francisco

Sponsor: Peter Ljubenkov, MD

Sex: All·Age: 18 - 85

Code: NCT05184569·Phase 1·Recruiting

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Longitudinal Assessment of Traumatic Microvascular Injury-2

for Traumatic Brain Injury

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05725993·Recruiting

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DISE: Phenotyping Obstruction Patterns

for Obstructive Sleep Apnea

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05050383·Recruiting

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Matching Perfusion and Metabolic Activity in HFpEF

for Heart Failure With Preserved Ejection Fraction

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04913805·Phase 2·Recruiting

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CapTemY90 for Grade 2/3 NET Liver Metastases

for Neuroendocrine Tumor Grade 2

4 locations incl. La Jolla

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04339036·Phase 2·Recruiting

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Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults

for Influenza, Human

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05108818·Phase 4·Recruiting

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A Study of Daratumumab and Dose-Adjusted EPOCH in Plasmablastic Lymphoma

for Plasmablastic Lymphoma

Drug: Daratumumab

8 locations incl. Miami

Sponsor: AIDS Malignancy Consortium

Sex: All·Age: 18+

Code: NCT04139304·EARLY_Phase 1·Recruiting

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Abatacept for the Treatment of Giant Cell Arteritis

for Giant Cell Arteritis

5 locations incl. Rochester

Sponsor: University of Pennsylvania

Sex: All·Age: 50+

Code: NCT04474847·Phase 3·Recruiting

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Localizing Epileptic Networks Using MRI and iEEG

for Epilepsy

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04649008·EARLY_Phase 1·Recruiting

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Longitudinal Study for Relapsing Polychondritis

for Relapsing Polychondritis

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT04919538·Recruiting

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Physiological Effects of ANGPTL3 Variants in Humans

for Hypocholesterolemia

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04234724·Recruiting

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Prospective 4D CTA of BAV Competence

for Bicuspid

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04645862·Recruiting

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Resuscitative TEE Collaborative Registry

for Cardiac Arrest

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04972526·Recruiting

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UPenn Observational Research Repository on Neurodegenerative Disease

for Frontotemporal Degeneration(FTD)

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04715399·Recruiting

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[18F]Fluoropropyl-Trimethoprim ([18F]F-TMP) PET/CT Imaging to Evaluate Biodistribution and Kinetics in Human Subjects

for Bacterial Infections

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04263792·Phase 1·Recruiting

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Comparison of the Short-Term Effect of Dietary Carbohydrate Restriction Versus Exogenous Ketone Supplementation on Myocardial Glucose Suppression and Timing to Achieve a State of Ketosis Using FDG PET/CT Serial Imaging

for Healthy

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04275453·Phase 1, Phase 2·Recruiting

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Parkinson's Disease and Movement Disorders Clinical Database

for Parkinson Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04997642·Recruiting

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Li-Fraumeni Syndrome/TP53 Biobank

for Li-Fraumeni Syndrome

2 locations incl. Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04367246·Recruiting

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Phenotyping Genetic Risk for Type 2 Diabetes

for Diabetes Mellitus, Type 2

2 locations incl. Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 10 - 70·Accepts healthy volunteers

Code: NCT04024631·Recruiting

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[18F] F-GLN by PET/CT in Breast Cancer

for Breast Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT03863457·Phase 1·Recruiting

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Safety Trial of Antimicrobial Therapy and Precision Radiation Therapy in Patients With Oligoprogressive Non-small Cell Lung Cancer

for Early Stage Non-Small Cell Lung Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT03546829·Phase 1·Recruiting

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Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation

for Smoking, Cigarette

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT03721822·Phase 1·Recruiting

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Study of Immune Responses to Influenza Vaccination

for Influenza Vaccination

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03346772·Phase 4·Recruiting

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HoFH, the International Clinical Collaborators Registry

for Homozygous Familial Hypercholesterolemia

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT04815005·Recruiting

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International Registry for Patients With Castleman Disease

for Castleman Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT02817997·Recruiting

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PET Tau - Neurodegenerative Disease Imaging

for Neurodegenerative Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT03143374·Phase 2, Phase 3·Recruiting

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Osteochondritis Dissecans of Knee Prospective Cohort

for Osteochondritis Dissecans

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT02771496·Recruiting

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The Cancer of the Pancreas Screening-5 CAPS5)Study

for Pancreas Cancer

9 locations incl. New Haven

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT02000089·Phase 3·Recruiting

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High Resolution Retinal Imaging

for Stargardts

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 7+·Accepts healthy volunteers

Code: NCT01866371·Recruiting

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The Radiation Oncology Registry and Biosample Repository

for Neoplasia

4 locations incl. Moorestown

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT01577251·Recruiting

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Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma

for Barrett's Esophagus

10 locations incl. Baltimore

Sponsor: Case Western Reserve University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT00288119·Recruiting

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Identifying Genetic Characteristics That Increase Risk of Primary Graft Dysfunction Following Lung Transplantation

for Primary Graft Dysfunction

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 15 - 65

Code: NCT00457847·Recruiting

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Risk Factors That Increase the Chance of Developing Primary Graft Dysfunction After Lung Transplantation

for Primary Graft Dysfunction

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 13 - 68

Code: NCT00552357·Recruiting

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