Clinical Trials at UPMC Hillman Cancer Center

As of June 2026, 91 paid clinical trials are recruiting at UPMC Hillman Cancer Center in Pittsburgh, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 8, 2026.

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91 clinical trials at UPMC Hillman Cancer Center

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A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian Cancers

for Epithelial Ovarian Cancer

5 locations incl. Boston

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT06469281·Phase 1·Recruiting

Apply to this trial

Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced or Metastatic HCC

for Hepatocellular Carcinoma

12 locations incl. Beverly Hills

Sponsor: Replimune, Inc.

Sex: All·Age: 18+

Code: NCT05733598·Phase 2·Recruiting

Apply to this trial

Dietary Interventions in Cancer Patients Treated With Immune Checkpoint Inhibitors

for Cancer

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT06475807·Recruiting

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IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)

for Advanced Melanoma

Drug: Nivolumab

37 locations incl. Tucson

Sponsor: Immunocore Ltd

Sex: All·Age: 18+

Code: NCT06112314·Phase 3·Recruiting

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A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)

for Thrombocythemia, Essential

4 locations incl. Ann Arbor

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06351631·Phase 3·Recruiting

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A Study of SNDX-5613 in Combination With Intensive Chemotherapy in Participants With Acute Myeloid Leukemias

for Acute Myeloid Leukemias

26 locations incl. Burbank

Sponsor: Syndax Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT06226571·Phase 1·Recruiting

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Liver Volume Variation Effect on SBRT Planning and Delivery for Upper Abdominal Malignancies

for Upper Abdominal Malignancies

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT06355895·Recruiting

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A Study Assessing KB707 for the Treatment of Advanced Solid Tumor Malignancies Affecting the Lungs

for Lung Cancer, Non-small Cell

14 locations incl. Dothan

Sponsor: Krystal Biotech, Inc.

Sex: All·Age: 18+

Code: NCT06228326·Phase 1, Phase 2·Recruiting

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A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors

for Oncology

17 locations incl. San Francisco

Sponsor: Nested Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT06326411·Phase 1·Recruiting

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Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors

for Ovarian Cancer

16 locations incl. Duarte

Sponsor: Xencor, Inc.

Sex: All·Age: 15+

Code: NCT06276491·Phase 1·Recruiting

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RP1 in Primary Melanoma to Reduce the Risk of Sentinel Lymph Node Metastasis

for Melanoma

1 location in Pittsburgh

Sponsor: Yana Najjar

Sex: All·Age: 18+

Code: NCT06216938·EARLY_Phase 1·Recruiting

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A Study of Alisertib in Patients With Extensive Stage Small Cell Lung Cancer

for Small Cell Lung Cancer

30 locations incl. Daphne

Sponsor: Puma Biotechnology, Inc.

Sex: All·Age: 18+

Code: NCT06095505·Phase 2·Recruiting

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Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC

for Non-Small Cell Lung Cancer, NSCLC

26 locations incl. Gilbert

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06162221·Phase 1, Phase 2·Recruiting

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A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY3537982

91 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06119581·Phase 3·Recruiting

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Study of ADI-PEG 20 or Placebo Plus Gem and Doc in Previously Treated Subjects With Leiomyosarcoma (ARGSARC)

for Soft Tissue Sarcoma

26 locations incl. Phoenix

Sponsor: Polaris Group

Sex: All·Age: 18 - 99

Code: NCT05712694·Phase 3·Recruiting

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Safety Study for a Gamma Delta T Cell Product Used With Low Dose Radiotherapy in Patients With Locally Advanced or Metastatic NSCLC or Solid Tumors With Bone Metastases

for Carcinoma, Non-Small-Cell Lung Cancer

5 locations incl. Tucson

Sponsor: Kiromic BioPharma Inc.

Sex: All·Age: 18+

Code: NCT06069570·Phase 1·Recruiting

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A Study Assessing KB707 for the Treatment of Locally Advanced or Metastatic Solid Tumors

for Cancer

15 locations incl. Los Angeles

Sponsor: Krystal Biotech, Inc.

Sex: All·Age: 18+

Code: NCT05970497·Phase 1, Phase 2·Recruiting

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KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

for Solid Tumors With HRAS Alterations

23 locations incl. Phoenix

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT06026410·Phase 1·Recruiting

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A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.

for Triple Negative Breast Cancer

Drug: Cemiplimab

9 locations incl. Los Angeles

Sponsor: OncoNano Medicine, Inc.

Sex: All·Age: 18+

Code: NCT06022029·Phase 1·Recruiting

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Pulsed Dose Chemotherapy Plus Pembrolizumab in Recurrent/Metastatic HNSCC

for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)

1 location in Pittsburgh

Sponsor: Dan Zandberg

Sex: All·Age: 18+

Code: NCT06052839·Phase 2·Recruiting

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A Study of ASKG915 in Patients With Selected Advanced Solid Tumors.

for Advanced Solid Tumors

2 locations incl. New York

Sponsor: AskGene Pharma, Inc.

Sex: All·Age: 18+

Code: NCT05867420·Phase 1, Phase 2·Recruiting

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MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma

for Recurrent Melanoma (Skin)

Drug: Nivolumab

13 locations incl. Orange

Sponsor: Perspective Therapeutics

Sex: All·Age: 18 - 90

Code: NCT05655312·Phase 1, Phase 2·Recruiting

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Vismodegib Combined With Atezolizumab in Platinum Resistant Ovarian, Fallopian Tube, and Primary Peritoneal Cancer

for Platinum-Resistant Fallopian Tube Carcinoma

Drug: Atezolizumab

1 location in Pittsburgh

Sponsor: Ronald Buckanovich

Sex: Female·Age: 18+

Code: NCT05538091·Phase 2·Recruiting

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ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

for H3 K27M

67 locations incl. Phoenix

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: All ages

Code: NCT05580562·Phase 3·Recruiting

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Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)

for Advanced Melanoma

Drug: Tebentafusp

25 locations incl. Phoenix

Sponsor: Immunocore Ltd

Sex: All·Age: 18+

Code: NCT05549297·Phase 3·Recruiting

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A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

for Melanoma

58 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 16+

Code: NCT05538130·Phase 1·Recruiting

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GD2-SADA:177Lu-DOTA Complex in Patients With Solid Tumors Known to Express GD2

for SCLC

8 locations incl. Scottsdale

Sponsor: Y-mAbs Therapeutics

Sex: All·Age: 16+

Code: NCT05130255·Phase 1·Recruiting

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A Substudy of Investigational Agents in Programmed Cell Death-1/Ligand 1 (PD-1/L1) Refractory Locally Advanced or Metastatic Urothelial Carcinoma (mUC) (MK-3475-04A)

for Urothelial Carcinoma

10 locations incl. Orange

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT05562830·Phase 1, Phase 2·Recruiting

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A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

for Colorectal Neoplasms

128 locations incl. Glendale

Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All·Age: 18+

Code: NCT05253651·Phase 3·Recruiting

Apply to this trial

TERPS Trial for de Novo Oligometastic Prostate Cancer

for Prostate Cancer

10 locations incl. La Jolla

Sponsor: University of Maryland, Baltimore

Sex: Male·Age: 18+

Code: NCT05223803·Phase 2·Recruiting

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Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

for Prostate Cancer

32 locations incl. Birmingham

Sponsor: Janux Therapeutics

Sex: Male·Age: 18 - 100

Code: NCT05519449·Phase 1·Recruiting

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Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation

for Multiple Myeloma

Drug: Teclistamab

42 locations incl. Phoenix

Sponsor: European Myeloma Network B.V.

Sex: All·Age: 18+

Code: NCT05243797·Phase 3·Recruiting

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A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer

for Unresectable Melanoma

10 locations incl. Los Angeles

Sponsor: Iovance Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT05361174·Phase 1, Phase 2·Recruiting

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Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer

for Oropharynx Cancer

1 location in Pittsburgh

Sponsor: Heath Skinner

Sex: All·Age: 18+

Code: NCT05388773·Phase 2·Recruiting

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Study of PLK1 Inhibitor, Onvansertib, in Relapsed Small Cell Lung Cancer

for Small-cell Lung Cancer

Drug: Onvansertib

2 locations incl. Baltimore

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18+

Code: NCT05450965·Phase 2·Recruiting

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Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers

for Advanced Solid Tumor

27 locations incl. Tucson

Sponsor: Synthekine

Sex: All·Age: 18+

Code: NCT05098132·Phase 1, Phase 2·Recruiting

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Long-term Follow-up Study for Participants of Kite-Sponsored Interventional Studies Treated With Gene-Modified Cells

for Solid and Hematological Malignancies

49 locations incl. Gilbert

Sponsor: Kite, A Gilead Company

Sex: All·Age: All ages

Code: NCT05041309·Enrolling By Invitation

Safety of SBRT With Anti-PD1 and Anti-IL-8 for the Treatment of Multiple Metastases in Advanced Solid Tumors and Melanoma

for Melanoma

2 locations incl. Chicago

Sponsor: Yana Najjar

Sex: All·Age: 18+

Code: NCT04572451·Phase 1·Recruiting

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Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

for Advanced Solid Tumor

6 locations incl. Santa Monica

Sponsor: Senhwa Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT04890613·Phase 1·Recruiting

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A Study of 177Lu-FAP-2286 in Advanced Solid Tumors

for Solid Tumor

20 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT04939610·Phase 1, Phase 2·Recruiting

Apply to this trial