Clinical Trials at University of Pittsburgh Medical Center

As of August 2026, 119 paid clinical trials are recruiting at University of Pittsburgh Medical Center, located at 200 LOTHROP ST, 933 W MONTEFIORE, PITTSBURGH, PA 15213-2536, phone (412) 692-4834 in Pittsburgh, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 24, 2026.

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119 clinical trials at University of Pittsburgh Medical Center

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A Long Term, Post-marketing Study of Immune Response in Patients Receiving Palynziq Treatment for PKU (PALisade)

for Phenylketonuria (PKU)

Sites in Pittsburgh +10 more locations

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: All ages

Code: NCT06305234·Recruiting·Listed Mar 2024

Apply to this trial

Safety and Efficacy of Tideglusib in Congenital or Childhood Onset Myotonic Dystrophy

for Congenital Myotonic Dystrophy

Sites in Pittsburgh +7 more locations

Sponsor: AMO Pharma Limited

Sex: All·Age: 6 - 45

Code: NCT05004129·Phase 2, Phase 3·Recruiting·Listed Aug 2021

Apply to this trial

Cardiac RADIoablation Versus Repeat Catheter Ablation: a Pivotal Randomized Clinical Trial Evaluating Safety and Efficacy for Patients With High-risk Refractory Ventricular Tachycardia (RADIATE-VT)

for Tachycardia, Ventricular

Sites in Pittsburgh, Philadelphia +9 more locations

Sponsor: Varian, a Siemens Healthineers Company

Sex: All·Age: 18+

Code: NCT05765175·Recruiting·Listed Mar 2023

Apply to this trial

Nafamostat Efficacy in Phase 3 Registrational CRRT Study

for Acute Kidney Injury

Sites in Pittsburgh +9 more locations

Sponsor: Talphera, Inc

Sex: All·Age: 18 - 80

Code: NCT06150742·Recruiting·Listed Nov 2023

Apply to this trial

A Study of TAK-755 in Adults With Acute Ischemic Stroke

for Acute Ischemic Stroke

Sites in Pittsburgh +8 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT07392450·Phase 2·Recruiting·Listed Feb 2026

Apply to this trial

AAV Gene Therapy Clinical Study in Adult Classic PKU (PHEdom)

for Phenylketonurias

Sites in Pittsburgh +4 more locations

Sponsor: NGGT INC.

Sex: All·Age: 18 - 55

Code: NCT06332807·Phase 1, Phase 2·Recruiting·Listed Mar 2024

Apply to this trial

Transdermal Compress IDE Study

for Prosthesis and Implants

Sites in Pittsburgh, Philidelphia +7 more locations

Sponsor: Balmoral Medical company

Sex: All·Age: 18 - 60

Code: NCT06134167·Recruiting·Listed Nov 2023

Apply to this trial

Effect of Ensifentrine on Sputum Markers of Inflammation in COPD

for COPD

Sites in Pittsburgh +2 more locations

Sponsor: Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA

Sex: All·Age: 40 - 80

Code: NCT05270525·Phase 2·Recruiting·Listed Mar 2022

Apply to this trial

Valved Graft PMCF Study

for Aortic Valve Disease

Sites in Pittsburgh, Philadelphia +1 more location

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT04754217·Recruiting·Listed Feb 2021

Apply to this trial

Study of CTO1681 for the Prevention and Treatment of CRS in DLBCL Patients Receiving CAR T-Cell Therapy

for Cytokine Release Syndrome

Sites in Pittsburgh +5 more locations

Sponsor: CytoAgents, Inc.

Sex: All·Age: 18+

Code: NCT05905328·Phase 1, Phase 2·Recruiting·Listed Jun 2023

Apply to this trial

Study Evaluating the Safety and Efficacy of an ECM Hydrogel for the Treatment of Anorectal Fistulas

for Fistula in Ano

Sites in Pittsburgh +1 more location

Sponsor: ECM Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07035925·Recruiting·Listed Jun 2025

Apply to this trial

A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors

for Solid Tumor

Sites in Pittsburgh +4 more locations

Sponsor: ImmVira Pharma Co. Ltd

Sex: All·Age: 18+

Code: NCT04370587·Phase 1, Phase 2·Recruiting·Listed May 2020

Apply to this trial

Phase 1/2 Study of Intratumoral Injection of STX-001 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab

for Advanced Solid Tumor

Sites in Pittsburgh +5 more locations

Sponsor: Strand Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06249048·Phase 1, Phase 2·Recruiting·Listed Feb 2024

Apply to this trial

Prospective Data Registry and Quality of Life Assessment of Patients Undergoing Radiotherapy With the RefleXion Medical Radiotherapy System

for Cancer

Sites in Pittsburgh +4 more locations

Sponsor: RefleXion Medical

Sex: All·Age: All ages

Code: NCT05406167·Recruiting·Listed Jun 2022

Apply to this trial

Malabsorption Blood Test (MBT) to Determine Exocrine Pancreatic Function and Related Quality of Life in Chronic Pancreatitis

for Chronic Pancreatitis

Sites in Pittsburgh +1 more location

Sponsor: Anna Evans Phillips

Sex: All·Age: 18+

Code: NCT07418593·Phase 4·Recruiting·Listed Feb 2026

Apply to this trial

Study to Enable New Diagnostics for Pulmonary Microbes in People With CF

for Cystic Fibrosis (CF)

Sites in Pittsburgh, Philadelphia +7 more locations

Sponsor: Chris Goss

Sex: All·Age: 16+

Code: NCT07312734·Recruiting·Listed Dec 2025

Apply to this trial

Bowel Continence Across the Lifespan in People With Spina Bifida

for Spina Bifida

Sites in Pittsburgh, Philadelphia +22 more locations

Sponsor: David Chu

Sex: All·Age: 5+

Code: NCT07390318·Recruiting·Listed Feb 2026

Apply to this trial

Brain-Stomach Circuits in Chronic Nausea

for Chronic Nausea and Vomiting Syndrome

1 location in Pittsburgh

Sponsor: David Levinthal

Sex: All·Age: 21 - 60·Accepts healthy volunteers

Code: NCT07276035·Recruiting·Listed Dec 2025

Apply to this trial

Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy

for Peripartum Cardiomyopathy, Postpartum

Sites in Pittsburgh, Hershey +59 more locations

Sponsor: Dennis M. McNamara, MD, MS

Sex: Female·Age: 18+

Code: NCT05180773·Phase 4·Recruiting·Listed Jan 2022

Apply to this trial

Collection of Tissue Samples for Cancer Research

for Neoplasms

Sites in Pittsburgh +9 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 2 Months+

Code: NCT00900198·Recruiting·Listed May 2009

Apply to this trial

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

Sites in Pittsburgh, Hershey +111 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting·Listed May 2011

Apply to this trial

QuantifyHER: Quantitative Immunofluorescence and/or RT-qPCR for Measuring HER2 in HER2-low Metastatic Breast Cancer

for HER2-positive Metastatic Breast Cancer

Sites in Pittsburgh, Philadelphia +35 more locations

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06551116·Recruiting·Listed Aug 2024

Apply to this trial

Cytomegalovirus (CMV) Vaccine in Orthotopic Liver Transplant Candidates

for Liver Transplant

Sites in Pittsburgh, Philadelphia +15 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18+

Code: NCT06075745·Phase 2·Recruiting·Listed Oct 2023

Apply to this trial

Simvastatin Treatment to Improve Patient-reported Outcomes in Patients With Chronic Pancreatitis

for Recurrent Acute Pancreatitis

Sites in Pittsburgh +4 more locations

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 18 - 75

Code: NCT05771675·EARLY_Phase 1·Recruiting·Listed Mar 2023

Apply to this trial

Subcortical Arousal in Perceptual Awareness

for Epilepsy

Sites in Pittsburgh +7 more locations

Sponsor: Yale University

Sex: All·Age: 13+

Code: NCT06934356·Recruiting·Listed Apr 2025

Apply to this trial

INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

for Glioblastoma

Sites in Pittsburgh +3 more locations

Sponsor: David Reardon, MD

Sex: All·Age: 18+

Code: NCT02977780·Phase 2·Recruiting·Listed Nov 2016

Apply to this trial

Neoadjuvant Neratinib in Stage I-III HER2-Mutated Lobular Breast Cancers

for Anatomic Stage I Breast Cancer

Sites in Pittsburgh +4 more locations

Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All·Age: 18+

Code: NCT05919108·Phase 2·Recruiting·Listed Jun 2023

Apply to this trial

Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis

for Systemic Sclerosis

3 locations in Pittsburgh

Sponsor: Paul Szabolcs

Sex: All·Age: 8 - 60

Code: NCT03630211·Phase 2·Recruiting·Listed Aug 2018

Apply to this trial

Cortical Excitability in Cyclic Vomiting Syndrome

for Cyclic Vomiting Syndrome

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT05256160·Recruiting·Listed Feb 2022

Apply to this trial

Inflammatory Bowel Disease (IBD) Research Registry

for Inflamatory Bowel Disease (Crohn's and Ulcerative Colitis)

1 location in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT04243525·Recruiting·Listed Jan 2020

Apply to this trial

Comparing Digital Therapy, Trazodone, and Daridorexant for Menopause-Related Insomnia Symptoms

for Menopausal Women

Drug: Daridorexant

Sites in Pittsburgh +4 more locations

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: 40 - 62

Code: NCT07136415·Phase 4·Recruiting·Listed Aug 2025

Apply to this trial

Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes

for Lung Transplant

Sites in Pittsburgh, Philadelphia +16 more locations

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06399302·Recruiting·Listed May 2024

Apply to this trial

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

for Cognitive Impairment, Mild

Sites in Pittsburgh, Philadelphia +89 more locations

Sponsor: Duke University

Sex: All·Age: 75+·Accepts healthy volunteers

Code: NCT04262206·Phase 4·Recruiting·Listed Feb 2020

Apply to this trial

The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry

for Cesarean Delivery

Sites in Pittsburgh +32 more locations

Sponsor: Yale University

Sex: Female·Age: 15 - 55·Accepts healthy volunteers

Code: NCT06030063·Recruiting·Listed Sep 2023

Apply to this trial

Pioglitazone Versus Empagliflozin for Chronic Pancreatitis/Recurrent Acute Pancreatitis/Acute Pancreatitis Associated Diabetes Mellitus

for Pancreatitis, Chronic

Drug: Empagliflozin

Sites in Pittsburgh +2 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80

Code: NCT06729996·Phase 2·Recruiting·Listed Dec 2024

Apply to this trial

Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

for Hiv

Sites in Pittsburgh, Philadelphia +16 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT06263426·Recruiting·Listed Feb 2024

Apply to this trial

Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapy

for Pulmonary Embolism

Sites in Pittsburgh, Wynnewood +38 more locations

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT05591118·Phase 3·Recruiting·Listed Oct 2022

Apply to this trial

ZEN003694 Combined With Talazoparib in Patients With Recurrent Ovarian Cancer

for Ovarian Cancer

1 location in Pittsburgh

Sponsor: Alexander B Olawaiye, MD

Sex: Female·Age: 18+

Code: NCT05071937·Phase 2·Recruiting·Listed Oct 2021

Apply to this trial

Get ActivE Study for At-risk Youth

for Anhedonia

Sites in Pittsburgh & Philadelphia

Sponsor: University of Pittsburgh

Sex: All·Age: 12 - 18

Code: NCT06829953·Recruiting·Listed Feb 2025

Apply to this trial

IMPRoving Outcomes in Vascular DisEase - Aortic Dissection

for Type B Aortic Dissection

Sites in Pittsburgh, Philadelphia +50 more locations

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT06087029·Recruiting·Listed Oct 2023

Apply to this trial