Paid Clinical Trials in Pittsburgh, PA

As of August 2026, 1,248 paid clinical trials are recruiting in Pittsburgh, Pennsylvania. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 10, 2026.

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1,100 clinical trials

A Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care Treatment

for Homocystinuria

Sites in Pittsburgh, Philadelphia +11 more locations

Sponsor: Travere Therapeutics, Inc.

Sex: All·Age: 12 - 65

Code: NCT06247085·Phase 3·Recruiting·Listed Feb 2024

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A Study of CHS-114 (Tagmokitug) in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors

for Metastatic Solid Tumor

Sites in Pittsburgh +17 more locations

Sponsor: Coherus Oncology, Inc.

Sex: All·Age: 18+

Code: NCT06657144·Phase 1·Recruiting·Listed Oct 2024

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AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy

for Mesial Temporal Lobe Epilepsy

Sites in Pittsburgh, Philadelphia +15 more locations

Sponsor: UniQure Biopharma B.V.

Sex: All·Age: 18 - 75

Code: NCT06063850·Phase 1, Phase 2·Recruiting·Listed Oct 2023

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BoxX-NoAF Clinical Trial

for Post Operative Atrial Fibrillation

Sites in Pittsburgh +23 more locations

Sponsor: AtriCure, Inc.

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT06989775·Recruiting·Listed May 2025

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Onyx™ Liquid Embolic IDE Clinical Study

for Peripheral Arterial Hemorrhage

Sites in Pittsburgh +16 more locations

Sponsor: Medtronic Endovascular

Sex: All·Age: 22+

Code: NCT06742801·Recruiting·Listed Dec 2024

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A Study to Evaluate the Safety and Effectiveness of the Rapidlink Device When Used in Patients Undergoing an Open Surgical Procedure to Repair the Aorta

for Aortic Aneurysm

Sites in Pittsburgh, Philadelphia +13 more locations

Sponsor: Vascutek Ltd.

Sex: All·Age: 18+

Code: NCT07078383·Recruiting·Listed Jul 2025

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A Study of BGB-16673 Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors

for CLL

Sites in Pittsburgh, York +23 more locations

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06846671·Phase 3·Recruiting·Listed Feb 2025

Apply to this trial

Abbott Cephea Mitral Valve Disease Registry

for Mitral Regurgitation

Sites in Pittsburgh +22 more locations

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT07069673·Recruiting·Listed Jul 2025

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Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

for Non-Small Cell Lung Cancer (NSCLC)

Drug: daraxonrasib

Sites in Pittsburgh +19 more locations

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06128551·Phase 1, Phase 2·Recruiting·Listed Nov 2023

Apply to this trial

Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease

for Primary Mitochondrial Disease

Sites in Pittsburgh, Philadelphia +18 more locations

Sponsor: Pharming Technologies B.V.

Sex: All·Age: 18+

Code: NCT05650229·Phase 2·Recruiting·Listed Dec 2022

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Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

for Metastatic Melanoma

Drug: Lifileucel

Sites in Pittsburgh +17 more locations

Sponsor: Iovance Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT05727904·Phase 3·Recruiting·Listed Feb 2023

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Intracept Minimally-invasive PROcedure for VErtebrogenic Back Pain

for Chronic Low-back Pain

Sites in Pittsburgh +15 more locations

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT06827262·Recruiting·Listed Feb 2025

Apply to this trial

The Ailliance Post-Market Clinical Study

for Spinal Deformity

Sites in Pittsburgh +22 more locations

Sponsor: Medtronic Spinal and Biologics

Sex: All·Age: 18+

Code: NCT05856370·Recruiting·Listed May 2023

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Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or ICI, for the Treatment of Patients With Advanced Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study)

for Gastric or Gastroesophageal Junction Adenocarcinoma

Sites in Pittsburgh +9 more locations

Sponsor: Phanes Therapeutics

Sex: All·Age: 18+

Code: NCT05482893·Phase 1, Phase 2·Recruiting·Listed Aug 2022

Apply to this trial

RevCore for In Stent Thrombosis

for In-stent Thrombosis

Sites in Pittsburgh, Philadelphia +14 more locations

Sponsor: Inari Medical

Sex: All·Age: 18+

Code: NCT06394739·Recruiting·Listed May 2024

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A Study of 177Lu-FAP-2286 in Advanced Solid Tumors

for Solid Tumor

Sites in Pittsburgh +19 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT04939610·Phase 1, Phase 2·Recruiting·Listed Jun 2021

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A Study of JNT-517 in Participants With Phenylketonuria (PKU)

for Phenylketonuria

Sites in Pittsburgh +9 more locations

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

Sex: All·Age: 18+

Code: NCT06971731·Phase 3·Recruiting·Listed May 2025

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A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

for Relapsed or Refractory Multiple Myeloma (RRMM)

Sites in Pittsburgh, Philadelphia +18 more locations

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06615479·Phase 3·Recruiting·Listed Sep 2024

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A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)

for Healthy Volunteers, Pulmonary Arterial Hypertension

Sites in Pittsburgh +19 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT06649110·Phase 1, Phase 2·Recruiting·Listed Oct 2024

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Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

for Heart Failure

Sites in Pittsburgh, Philadelphia +18 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 29 Days - 17

Code: NCT05714085·Phase 2, Phase 3·Recruiting·Listed Feb 2023

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Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer

for Ovarian Cancer

Sites in Pittsburgh +20 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT06787612·Phase 2·Recruiting·Listed Jan 2025

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Lead-212 PSV359 Therapy for Patients With Solid Tumors

for Pancreatic Ductal Adenocarcinoma

Sites in Pittsburgh +10 more locations

Sponsor: Perspective Therapeutics

Sex: All·Age: 18 - 90

Code: NCT06710756·Phase 1, Phase 2·Recruiting·Listed Nov 2024

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A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

for Anemia, Sickle Cell

Sites in Pittsburgh, Philadelphia +16 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06481306·Phase 1, Phase 2·Recruiting·Listed Jul 2024

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A Study of SYNC-T Therapy SV-102 in Participants With Metastatic Castration-Resistant Prostate Cancer

for Metastatic Castration-resistant Prostate Cancer

Sites in Pittsburgh, Philadelphia +21 more locations

Sponsor: Syncromune, Inc.

Sex: Male·Age: 18+

Code: NCT06533644·Phase 2·Recruiting·Listed Aug 2024

Apply to this trial

XTX301 in Patients With Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Pittsburgh +9 more locations

Sponsor: Xilio Development, Inc.

Sex: All·Age: 18+

Code: NCT05684965·Phase 1, Phase 2·Recruiting·Listed Jan 2023

Apply to this trial

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

for Solid Tumors With HRAS Alterations

Sites in Pittsburgh +21 more locations

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT06026410·Phase 1·Recruiting·Listed Sep 2023

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A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia Gravis

for Generalized Myasthenia Gravis

Drug: Remibrutinib

Sites in Pittsburgh +23 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 85

Code: NCT06744920·Phase 3·Recruiting·Listed Dec 2024

Apply to this trial

DOC1021 Dendritic Cell Immunotherapy for Treatment of Newly Diagnosed Adult Glioblastoma (GBM)

for Glioblastoma (GBM)

Sites in Pittsburgh +16 more locations

Sponsor: Diakonos Oncology Corporation

Sex: All·Age: 18+

Code: NCT06805305·Phase 2·Recruiting·Listed Feb 2025

Apply to this trial

A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)

for Chronic Graft-versus-host-disease

Sites in Pittsburgh +10 more locations

Sponsor: Incyte Corporation

Sex: All·Age: 2 - 17

Code: NCT07124078·Phase 2·Recruiting·Listed Aug 2025

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Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors

for Ovarian Cancer

Sites in Pittsburgh +16 more locations

Sponsor: Xencor, Inc.

Sex: All·Age: 15+

Code: NCT06276491·Phase 1·Recruiting·Listed Feb 2024

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A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.

for Candidemia

Sites in Pittsburgh, Philadelphia +20 more locations

Sponsor: Basilea Pharmaceutica

Sex: All·Age: 18+

Code: NCT05421858·Phase 3·Recruiting·Listed Jun 2022

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A Study of Tarlatamab in Combination With AB248 in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-311)

for Extensive Stage Small Cell Lung Cancer

Drug: Tarlatamab

Sites in Pittsburgh, Philadelphia +11 more locations

Sponsor: Amgen

Sex: All·Age: 18 - 90

Code: NCT07037758·Phase 1·Recruiting·Listed Jun 2025

Apply to this trial

The PERSEVERE Study

for Pulmonary Embolism

Sites in Pittsburgh, Philadelphia +13 more locations

Sponsor: Inari Medical

Sex: All·Age: 18+

Code: NCT06588634·Recruiting·Listed Sep 2024

Apply to this trial

Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer

for Prostate Cancer

Sites in Pittsburgh +23 more locations

Sponsor: Novartis Pharmaceuticals

Sex: Male·Age: 18 - 100

Code: NCT05803941·Phase 4·Recruiting·Listed Apr 2023

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MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma

for Recurrent Melanoma (Skin)

Drug: Nivolumab

Sites in Pittsburgh, Philadelphia +10 more locations

Sponsor: Perspective Therapeutics

Sex: All·Age: 18 - 90

Code: NCT05655312·Phase 1, Phase 2·Recruiting·Listed Dec 2022

Apply to this trial

Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)

for Acute Respiratory Distress Syndrome

Sites in Pittsburgh, Hershey +12 more locations

Sponsor: BioAegis Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT05947955·Phase 2·Recruiting·Listed Jul 2023

Apply to this trial

A Study Assessing HMB-002 in Participants With Von Willebrand Disease

for Von Willebrand Disease (VWD)

Sites in Pittsburgh +12 more locations

Sponsor: Hemab ApS

Sex: All·Age: 16 - 69

Code: NCT06754852·Phase 1, Phase 2·Recruiting·Listed Jan 2025

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A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes

for Diabetes Mellitus, Type 1

Sites in Pittsburgh, Philadelphia +9 more locations

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 65

Code: NCT04786262·Phase 3·Recruiting·Listed Mar 2021

Apply to this trial

Vivistim Registry for Paired VNS Therapy (GRASP)

for Upper Extremity Problem

Sites in Pittsburgh, Scranton +13 more locations

Sponsor: MicroTransponder Inc.

Sex: All·Age: 22+

Code: NCT05301140·Recruiting·Listed Mar 2022

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A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer

for Unresectable Melanoma

Sites in Pittsburgh +9 more locations

Sponsor: Iovance Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT05361174·Phase 1, Phase 2·Recruiting·Listed May 2022

Apply to this trial