Paid Clinical Trials in Rochester, MN

As of September 2026, 1,216 paid clinical trials are recruiting in Rochester, Minnesota. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

Filter results

Filter results

State

City

Facility

Recruitment status

Phase

Study type

Intervention

Condition

Sex

Age

Healthy volunteers only

1,028 clinical trials

Get a weekly email when new trials open in Rochester, MN.

Phase Ib Study of Axatilimab in Combination With Olaparib in BRCA1/2 and PALB2- Associated Metastatic HER2-negative Breast Cancer

for Breast Cancer

Sites in Rochester +1 more location

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06488378·Phase 1·Recruiting·Listed Jul 2024

Apply to this trial

Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

for Recurrent Glioblastoma, IDH-Wildtype

Drug: Selinexor

Sites in Rochester +27 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05432804·Phase 1, Phase 2·Recruiting·Listed Jun 2022

Apply to this trial

Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry

for Rheumatic Joint Disease

Sites in Rochester, Minneapolis +64 more locations

Sponsor: Duke University

Sex: All·Age: Up to 21

Code: NCT02418442·Recruiting·Listed Apr 2015

Apply to this trial

Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

for Migraine

Sites in Rochester +35 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 70

Code: NCT06972056·Phase 4·Recruiting·Listed May 2025

Apply to this trial

Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants

for Inherited Retinal Degeneration

Sites in Rochester +18 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4+

Code: NCT05589714·Recruiting·Listed Oct 2022

Apply to this trial

Cytomegalovirus (CMV) Vaccine in Orthotopic Liver Transplant Candidates

for Liver Transplant

Sites in Rochester +16 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18+

Code: NCT06075745·Phase 2·Recruiting·Listed Oct 2023

Apply to this trial

International CRDS Registry

for Calcium Release Deficiency Syndrome

Sites in Rochester +3 more locations

Sponsor: Population Health Research Institute

Sex: All·Age: All ages

Code: NCT06508164·Recruiting·Listed Jul 2024

Apply to this trial

A Multi-Center Observational Trial of Symptomatic, High-Risk Bone Metastases Treated With Percutaneous Ablation and Palliative Radiation Therapy

for Bone Cancer Metastatic

Sites in Rochester +7 more locations

Sponsor: Society of Interventional Oncology

Sex: All·Age: 21+

Code: NCT06859801·Recruiting·Listed Mar 2025

Apply to this trial

Testing the Addition of Abemaciclib to Olaparib for Women With Recurrent Ovarian Cancer

for Recurrent Ovarian High Grade Serous Adenocarcinoma

Sites in Rochester +10 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT04633239·Phase 1·Recruiting·Listed Nov 2020

Apply to this trial

Clinical and Basic Investigations Into Congenital Disorders of Glycosylation

for Congenital Disorders of Glycosylation

Sites in Rochester, Minneapolis +10 more locations

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: All ages

Code: NCT04199000·Recruiting·Listed Dec 2019

Apply to this trial

Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

for Colorectal Carcinoma

Sites in Rochester +7 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05410977·Recruiting·Listed Jun 2022

Apply to this trial

Testing Teclistamab (TECVAYLI) in Combination With Iberdomide for Relapsed or Refractory Multiple Myeloma

for Recurrent Multiple Myeloma

Drug: Teclistamab

Sites in Rochester +13 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06465316·Phase 1·Recruiting·Listed Jun 2024

Apply to this trial

Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

for Metastatic Colorectal Carcinoma

Sites in Rochester, Minneapolis +52 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT05863195·Phase 3·Recruiting·Listed May 2023

Apply to this trial

Ketogenic Intervention for Bipolar Depression

for Bipolar Depression

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 50

Code: NCT07121894·Recruiting·Listed Aug 2025

Apply to this trial

Minibeam Radiation Therapy With Tungsten Slit Collimator for the Treatment of Recurrent or Metastatic Skin or Soft Tissue Tumors

for Metastatic Malignant Skin Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07062003·Recruiting·Listed Jul 2025

Apply to this trial

Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

for Acute Respiratory Distress Syndrome

Sites in Rochester +32 more locations

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06066502·Phase 3·Recruiting·Listed Oct 2023

Apply to this trial

Subcortical Arousal in Perceptual Awareness

for Epilepsy

Sites in Rochester +7 more locations

Sponsor: Yale University

Sex: All·Age: 13+

Code: NCT06934356·Recruiting·Listed Apr 2025

Apply to this trial

RA-PRO PRAGMATIC TRIAL

for Rheumatoid Arthritis

Sites in Rochester, Eagan +46 more locations

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT04692493·Phase 3·Recruiting·Listed Dec 2020

Apply to this trial

Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma

for Progressive Glioblastoma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07076472·EARLY_Phase 1·Recruiting·Listed Jul 2025

Apply to this trial

An International Observational Study of Adults With Acute Infection

for Infectious Disease

Sites in Rochester, Minneapolis +18 more locations

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT07069400·Recruiting·Listed Jul 2025

Apply to this trial

Continuous Glucose Monitoring for the Management of Hyperglycemia in Patients With Glioblastoma

for Glioblastoma, IDH-Wildtype

Sites in Rochester +2 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07091864·Recruiting·Listed Jul 2025

Apply to this trial

Voices: Messages of Wisdom and Hope in the Face of Illness

for Hematopoietic and Lymphatic System Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07381179·Recruiting·Listed Feb 2026

Apply to this trial

A Study Of Deep Learning For Echo Analysis, Tracking, And Evaluation

for Cardiomyopathy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07308704·Recruiting·Listed Dec 2025

Apply to this trial

BMS-986340 in Combination With Nivolumab, Gemcitabine and Nab-paclitaxel for the Treatment of Metastatic and Recurrent Pancreatic Adenocarcinoma

for Metastatic Pancreatic Adenocarcinoma

Drug: Nivolumab

Sites in Rochester +2 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07226856·Phase 2·Recruiting·Listed Nov 2025

Apply to this trial

Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting

for Respiratory Distress Syndrome, Newborn

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 32 Weeks - 41 Weeks·Accepts healthy volunteers

Code: NCT07344714·Recruiting·Listed Jan 2026

Apply to this trial

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

for Stage I Breast Cancer

Sites in Rochester, Burnsville +705 more locations

Sponsor: NRG Oncology

Sex: All·Age: 50 - 70

Code: NCT04852887·Phase 3·Recruiting·Listed Apr 2021

Apply to this trial

Acceptance and Commitment Therapy for the Improvement of Cancer Distress in Patients With Incurable Cancers, ACT-C Trial

for Malignant Hepatobiliary Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07124546·Recruiting·Listed Aug 2025

Apply to this trial

High Resolution Gastric Mapping and Gastroduodenal Manometry

for Dyspepsia

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80

Code: NCT06941545·Recruiting·Listed Apr 2025

Apply to this trial

A 3D-Printed External Breast Prosthesis for the Improvement of Patient-reported Outcomes Among Breast Cancer Patients That Underwent a Mastectomy Without Reconstruction

for Breast Carcinoma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07047872·Recruiting·Listed Jul 2025

Apply to this trial

A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma, GHoST Trial

for Glioma

Sites in Rochester +1 more location

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07074756·Recruiting·Listed Jul 2025

Apply to this trial

Fibrosis Lessens After Metabolic Surgery

for Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD)

Sites in Rochester +3 more locations

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06374875·Phase 4·Recruiting·Listed Apr 2024

Apply to this trial

Proton or Photon RT for Retroperitoneal Sarcomas

for Retroperitoneal Sarcoma

Sites in Rochester +9 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT01659203·Phase 1, Phase 2·Recruiting·Listed Aug 2012

Apply to this trial

Clinical Trial of Concomitant Hip Arthroscopy During PAO

for Hip Dysplasia

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 15 - 55

Code: NCT03181048·Recruiting·Listed Jun 2017

Apply to this trial

Exercise Response in Humans With Obesity

for Obese

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 20 - 45

Code: NCT05857150·Recruiting·Listed May 2023

Apply to this trial

A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)

for Coarctation of Aorta

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06150560·Phase 3·Recruiting·Listed Nov 2023

Apply to this trial

A Study of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation

for Lung Transplant

Sites in Rochester +8 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05547698·Recruiting·Listed Sep 2022

Apply to this trial

A Study of Vemurafenib and Obinutuzumab Compared to Cladribine and Rituximab in People With Hairy Cell Leukemia (HCL)

for Hairy Cell Leukemia

Drug: Rituximab

Sites in Rochester +9 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06561360·Phase 2·Recruiting·Listed Aug 2024

Apply to this trial

Influence of Pulse Electromagnetic Field Therapy on Myocardial Ischemia

for Coronary Artery Disease

Sites in Rochester +1 more location

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05111288·Recruiting·Listed Nov 2021

Apply to this trial

Molecular Analysis of Suspected or High-Risk Lung Cancer to Drive Individualized Care

for Lung Carcinoma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06482073·Recruiting·Listed Jul 2024

Apply to this trial

Testing the Combination of DS-8201a and Olaparib in HER2-Expressing Cancers With Expansion in Patients With Platinum Resistant Ovarian Cancer

for Metastatic Malignant Solid Neoplasm

Sites in Rochester +11 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04585958·Phase 1·Recruiting·Listed Oct 2020

Apply to this trial