Oncology Clinical Trials in Santa Monica, CA

As of July 2026, 78 paid clinical trials are recruiting for Oncology in Santa Monica, California. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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78 clinical trials for Oncology

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Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

for Non-small Cell Lung Cancer

Sites in Santa Monica, La Jolla +20 more locations

Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

Sex: All·Age: 18+

Code: NCT06343402·Phase 1·Recruiting·Listed Apr 2024

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Phase 1/2 Study of PYX-201 in Combination With Pembrolizumab in Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Santa Monica, San Diego +9 more locations

Sponsor: Pyxis Oncology, Inc

Sex: All·Age: 18+

Code: NCT06795412·Phase 1, Phase 2·Recruiting·Listed Jan 2025

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A Study of LY4050784 in Participants With Advanced or Metastatic Solid Tumors

for Metastatic Solid Tumor

Sites in Santa Monica +15 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06561685·Phase 1·Recruiting·Listed Aug 2024

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A Study of DB-1310 in Advanced/Metastatic Solid Tumors

for Advanced Solid Tumor

Sites in Santa Monica, Sacramento +10 more locations

Sponsor: DualityBio Inc.

Sex: All·Age: 18+

Code: NCT05785741·Phase 1, Phase 2·Recruiting·Listed Mar 2023

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A Phase 1 Study of CPO301 in Adult Patients With Advanced or Metastatic Solid Tumors

for Cancer

Sites in Santa Monica, Los Angeles +9 more locations

Sponsor: Conjupro Biotherapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05948865·Phase 1·Recruiting·Listed Jul 2023

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Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

for Non Small Cell Lung Cancer

Sites in Santa Monica, Beverly Hills +22 more locations

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT05983432·Phase 1·Recruiting·Listed Aug 2023

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Evaluation of RBS2418 in Subjects With Advanced, Metastatic Solid Tumors

for Advanced Cancer

Sites in Santa Monica, Palo Alto +10 more locations

Sponsor: Riboscience, LLC.

Sex: All·Age: 18+

Code: NCT05270213·Phase 1·Recruiting·Listed Mar 2022

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A First-in-Human Study of YL217 in Patients With Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Santa Monica +12 more locations

Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All·Age: 18+

Code: NCT06859762·Phase 1·Recruiting·Listed Mar 2025

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A Study of TRK-950 When Used in Combination With Ramucirumab and Paclitaxel in Patients With Gastric Cancer

for Gastric Adenocarcinoma

Sites in Santa Monica, Duarte +12 more locations

Sponsor: Toray Industries, Inc

Sex: All·Age: 18+

Code: NCT06038578·Phase 2·Recruiting·Listed Sep 2023

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uTRACT Jelmyto Registry: A Registry of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto

for Urothelial Carcinoma

Sites in Santa Monica +21 more locations

Sponsor: UroGen Pharma Ltd.

Sex: All·Age: 18+

Code: NCT05874921·Recruiting·Listed May 2023

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A Study of ZW251 in Participants With Advanced Solid Tumors

for Hepatocellular Carcinoma

Sites in Santa Monica, San Francisco +6 more locations

Sponsor: Zymeworks BC Inc.

Sex: All·Age: 18+

Code: NCT07164313·Phase 1·Recruiting·Listed Sep 2025

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Study of Patritumab Deruxtecan Plus Pembrolizumab With Other Anticancer Agents in Participants With High-Risk Early-Stage Triple-Negative or Hormone Receptor-Low Positive/HER-2 Negative Breast Cancer (MK-1022-010, HERTHENA-Breast-03)

for Breast Neoplasms

Sites in Santa Monica +7 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06797635·Phase 2·Recruiting·Listed Jan 2025

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A Study to Test the Safety and Tolerability of SBO-154 in Patients With Advanced Solid Tumors.

for Advanced Solid Tumors

Sites in Santa Monica +4 more locations

Sponsor: Sun Pharma Advanced Research Company Limited

Sex: All·Age: 18+

Code: NCT07042100·Phase 1·Recruiting·Listed Jun 2025

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Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

for Advanced Solid Tumor

Sites in Santa Monica +4 more locations

Sponsor: Senhwa Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT04890613·Phase 1·Recruiting·Listed May 2021

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A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

for Solid Tumours

Sites in Santa Monica, Beverly Hills +1 more location

Sponsor: Epkin

Sex: All·Age: 18+

Code: NCT06789172·Phase 1·Recruiting·Listed Jan 2025

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Study to Evaluate IMGS-001 Treatment in Patients With Relapsed or Refractory Advanced Solid Tumors

for Solid Tumor

Sites in Santa Monica +5 more locations

Sponsor: ImmunoGenesis

Sex: All·Age: 18+

Code: NCT06014502·Phase 1·Recruiting·Listed Aug 2023

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A Study to Evaluate the Adverse Events, Efficacy, and Optimal Dose of Intravenous (IV) ABBV-400 in Combination With IV Fluorouracil, Leucovorin, and Budigalimab in Adult Participants With Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

for Locally Advanced Unresectable or Metastatic Gastric Adenocarcinoma

Sites in Santa Monica, Duarte +6 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06628310·Phase 2·Recruiting·Listed Oct 2024

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Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmocodynamics and Preliminary Antitumor Activity of AT-1965 in Patients With Advanced, Refractory or Recurrent Solid Tumors

for Solid Tumor

Sites in Santa Monica, El Segundo +5 more locations

Sponsor: Alyssum Therapeutics

Sex: All·Age: 18+

Code: NCT06234098·Phase 1, Phase 2·Recruiting·Listed Jan 2024

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Open-Label, Dose-Escalation With Expansion to Assess the Safety, Tolerability, and PK of TRE-515 in Subjects With Solid Tumors

for Solid Tumor, Adult

Sites in Santa Monica +1 more location

Sponsor: Trethera

Sex: All·Age: 18+

Code: NCT05055609·Phase 1·Recruiting·Listed Sep 2021

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A Study of ADRX-0405 in Subjects With Select Advanced Solid Tumors

for Solid Tumors

Sites in Santa Monica, Duarte +6 more locations

Sponsor: Adcentrx Therapeutics

Sex: All·Age: 18+

Code: NCT06710379·Phase 1·Recruiting·Listed Nov 2024

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A Beta-only IL-2 ImmunoTherapY Study

for Advanced Solid Tumor

Sites in Santa Monica, San Diego +3 more locations

Sponsor: Medicenna Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05086692·Phase 1, Phase 2·Recruiting·Listed Oct 2021

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This is a Study to Evaluate the Safety and Tolerability of ABL503, and to Determine the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D) of ABL503 in Subjects with Any Progressive Locally Advanced or Metastatic Solid Tumors

for Advanced Solid Tumor

Sites in Santa Monica, Los Angeles +3 more locations

Sponsor: ABL Bio, Inc.

Sex: All·Age: 18+

Code: NCT04762641·Phase 1·Recruiting·Listed Feb 2021

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Urine Metabolites in the Diagnosis of Disease

for Colorectal Cancer

Sites in Santa Monica, Encinitas & Walnut Creek

Sponsor: Luventix, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06710067·Recruiting·Listed Nov 2024

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A Study of BRIA-OTS Cellular Immunotherapy in Metastatic Recurrent Breast Cancer

for Breast Cancer

1 location in Santa Monica

Sponsor: BriaCell Therapeutics Corporation

Sex: All·Age: 18+

Code: NCT06471673·Phase 1, Phase 2·Recruiting·Listed Jun 2024

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Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

for Advanced Malignant Solid Neoplasm

Sites in Santa Monica, Los Angeles +428 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: All ages

Code: NCT05564377·Phase 2·Recruiting·Listed Oct 2022

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Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors

for Breast Cancer

Sites in Santa Monica, Los Angeles +635 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18 - 100

Code: NCT05896189·Recruiting·Listed Jun 2023

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A Phase 2 Study of the Ketogenic Diet vs Standard Anti-cancer Diet Guidance for Patients With Glioblastoma in Combination With Standard-of-care Treatment

for Glioblastoma Multiforme

Sites in Santa Monica, Los Angeles +2 more locations

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 18+

Code: NCT05708352·Phase 2·Recruiting·Listed Feb 2023

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Talimogene Laherparepvec, Nivolumab and Trabectedin for Sarcoma

for Sarcoma

Drug: Nivolumab

1 location in Santa Monica

Sponsor: Sarcoma Oncology Research Center, LLC

Sex: All·Age: 18+

Code: NCT03886311·Phase 2·Recruiting·Listed Mar 2019

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Registry for Intra-Operative Radiotherapy During Breast Conserving Surgery in Patients With Early Stage Breast Cancer

for Early-stage Breast Cancer

1 location in Santa Monica

Sponsor: Saint John's Cancer Institute

Sex: All·Age: 18+

Code: NCT04603209·Recruiting·Listed Oct 2020

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GALLANT: Metronomic Gemcitabine, Doxorubicin, Docetaxel and Nivolumab for Advanced Sarcoma

for Sarcoma

Drug: Nivolumab

1 location in Santa Monica

Sponsor: Sarcoma Oncology Research Center, LLC

Sex: All·Age: 18+

Code: NCT04535713·Phase 2·Recruiting·Listed Sep 2020

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A Study of Rilvegostomig or Durvalumab Plus Chemotherapy for First-Line Treatment of Biliary Tract Cancer (ARTEMIDE-Biliary02)

for Biliary Tract Cancer

Drug: Rilvegostomig

Sites in Santa Monica, Duarte +33 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07221253·Phase 3·Recruiting·Listed Oct 2025

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A Study of Novel Combinations in Non-Small Cell Lung Cancer (NSCLC)

for Non-Small Cell Lung Cancer

Sites in Santa Monica, Santa Rosa +4 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07098338·Phase 2·Recruiting·Listed Aug 2025

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A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

for Breast Cancer

Sites in Santa Monica, Santa Rosa +8 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05123482·Phase 1, Phase 2·Recruiting·Listed Nov 2021

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A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

for Non-small Cell Lung Cancer

Sites in Santa Monica, Duarte +12 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05877599·Phase 1·Recruiting·Listed May 2023

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Study for AZD4360 in Participants With Advanced Solid Tumours

for Gastric Cancer

Sites in Santa Monica +2 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06921928·Phase 1, Phase 2·Recruiting·Listed Apr 2025

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A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Solid Tumors

for Clear Cell Renal Cell Carcinoma

Sites in Santa Monica, San Diego +18 more locations

Sponsor: Arcus Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT05536141·Phase 1·Recruiting·Listed Sep 2022

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A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

for HER2-positive Gastric Cancer

Drug: Rilvegostomig

Sites in Santa Monica, Los Angeles +43 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06764875·Phase 3·Recruiting·Listed Jan 2025

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Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer

for Non-small Cell Lung Cancer

Drug: Osimertinib

Sites in Santa Monica, Los Angeles +26 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06350097·Phase 3·Recruiting·Listed Apr 2024

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Conditions in Oncology (Santa Monica, CA)

Solid tumor· 24 Non-small cell lung cancer (NSCLC)· 16 Breast cancer· 14 Colorectal cancer· 9 Pancreatic cancer· 6 Ovarian cancer· 6 Esophageal cancer· 5 Gastroesophageal junction cancer· 5 Prostate cancer· 5 Cancer (any)· 5 Bladder cancer· 4 Endometrial cancer· 4 Head and neck cancer· 4 Triple-negative breast cancer· 3 Gastric cancer· 3 Non-Hodgkin lymphoma· 3 Sarcoma· 3 Metastatic breast cancer· 2 Biliary tract cancer· 2 Metastatic prostate cancer· 2 Cervical cancer· 2 Fallopian tube cancer· 2 Melanoma· 2 Lung cancer· 1 Small cell lung cancer· 1 Metastatic colorectal cancer· 1 Liver cancer· 1 Glioblastoma· 1 Glioma· 1 Chronic lymphocytic leukemia (CLL)· 1 Diffuse large B-cell lymphoma (DLBCL)· 1 Follicular lymphoma· 1 Mantle cell lymphoma· 1 Marginal zone lymphoma· 1 Small lymphocytic lymphoma· 1 Hematologic malignancy· 1 Skin cancer· 1 Thyroid cancer· 1 Ewing sarcoma· 1 Mesothelioma· 1