Paid Clinical Trials in South Carolina

South Carolina has 1,277 paid clinical trials enrolling now across cities including Charleston, Greenville and Columbia. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

Filter results

State

City

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

1,277 clinical trials

↓ Download CSV

Open-Label Safety Study of AXS-14 in Subjects With Fibromyalgia

for Fibromyalgia

8 locations incl. Santa Ana

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07637162·Phase 3·Enrolling By Invitation

Sex Differences in Neurobehavioral Response to THC

for Cannabis Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21 - 45

Code: NCT07225777·Phase 2·Recruiting

Apply to this trial

Direct vs Standard SLT for Glaucoma: A Noninferiority Trial

for Open-angle Glaucoma (OAG)

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07408154·Recruiting

Apply to this trial

Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

for Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

70 locations incl. Tucson

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07195734·Phase 2·Recruiting

Apply to this trial

Community Health Worker Coaching to Reduce Cardiovascular Risk Among Women After a Hypertensive Disorder of Pregnancy

for Blood Pressure Monitoring

1 location in Columbia

Sponsor: University of South Carolina

Sex: Female·Age: 18+

Code: NCT07457970·Recruiting

Apply to this trial

A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 2

for Narcolepsy Type 2

Drug: ALKS 2680

13 locations incl. Boulder

Sponsor: Alkermes, Inc.

Sex: All·Age: 18 - 70

Code: NCT07502443·Phase 3·Recruiting

Apply to this trial

A Study of TSRA-196 in Adults With PiZZ Alpha-1 Antitrypsin Deficiency (AATD)

for Alpha-1 Antitrypsin Deficiency (AATD)

2 locations incl. Boston

Sponsor: Tessera Therapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT07227207·Phase 1, Phase 2·Recruiting

Apply to this trial

A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn's Disease

for Crohn Disease

Drug: Risankizumab

17 locations incl. Dothan

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07499232·Phase 3·Recruiting

Apply to this trial

Study to Evaluate Tulisokibart in Adults With Psoriatic Arthritis (MK-7240-015)

for Psoriatic Arthritis

Drug: Tulisokibart

15 locations incl. Sun City

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18 - 80

Code: NCT07486960·Phase 2·Recruiting

Apply to this trial

EVERO Drug-coated Balloon (DCB) Randomized Trial

for Peripheral Vascular Disease

3 locations incl. Gainesville

Sponsor: Cook Research Incorporated

Sex: All·Age: 18+

Code: NCT07144150·Recruiting

Apply to this trial

Add-On ZIDA Sock Therapy for Overactive Bladder

for Overactive Bladder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07432659·Recruiting

Apply to this trial

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)

for Macular Degeneration

9 locations incl. Mountain View

Sponsor: EyeBiotech Ltd.

Sex: All·Age: 50+

Code: NCT07496567·Phase 2, Phase 3·Recruiting

Apply to this trial

A Study of GEN1106 in Participants With Solid Tumors

for Solid Tumors

Drug: GEN1106

4 locations incl. New Haven

Sponsor: Genmab

Sex: All·Age: 18+

Code: NCT07416123·Phase 1·Recruiting

Apply to this trial

A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

for Obesity

Drug: NNC0487-0111

19 locations incl. Phoenix

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07481630·Phase 3·Recruiting

Apply to this trial

AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight

for Diabetes Mellitus

Drug: NNC0487-0111

15 locations incl. Birmingham

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07533175·Phase 3·Recruiting

Apply to this trial

A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

for Solid Tumors

Drug: INCB161734

68 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07522073·Phase 3·Recruiting

Apply to this trial

Building Retention and Initiation Through Delivery of Peer-Guided Evidence-Based Practices

for Opioid Use Disorder

1 location in Greenville

Sponsor: Prisma Health-Upstate

Sex: All·Age: 18+

Code: NCT07541417·Recruiting

Apply to this trial

A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 1

for Narcolepsy Type 1

Drug: ALKS 2680

15 locations incl. Los Angeles

Sponsor: Alkermes, Inc.

Sex: All·Age: 18 - 70

Code: NCT07455383·Phase 3·Recruiting

Apply to this trial

Dietary Insights and Nutritional Education in Adults on GLP-1 Therapy

for Obesity Type 2 Diabetes Mellitus

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 18 - 65

Code: NCT07518407·Recruiting

Apply to this trial

Evaluating NALIRIFOX vs Modified Gemcitabine, Nab-Paclitaxel and Cisplatin in Patients With Locally Advanced and Metastatic Pancreatic Adenocarcinoma

for Metastatic Pancreatic Adenocarcinoma

2 locations incl. Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07076212·Phase 2·Recruiting

Apply to this trial

Atomoxetine and Executive Function in PTSD

for Posttraumatic Stress Disorder With Attention Defic

1 location in Charleston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06573970·Phase 4·Not Yet Recruiting

Church Implementation of a Social Support Intervention to Increase Physical Activity in Older African American Adults

for Healthy Participants

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT07340099·Not Yet Recruiting

Mindfulness Training During Accelerated TMS for Depression

for Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 80

Code: NCT07369557·Not Yet Recruiting

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)

for Macular Degeneration

42 locations incl. Scottsdale

Sponsor: EyeBiotech Ltd.

Sex: All·Age: 50+

Code: NCT07440225·Phase 2, Phase 3·Recruiting

Apply to this trial

A Study to Evaluate the Safety, Tolerability, and Efficacy of Pumitamig Alone or in Combination With Ipilimumab or Cabozantinib in Participants With Advanced Renal Cell Carcinoma (RCC) (ROSETTA RCC-208)

for Advanced Renal Cell Carcinoma (RCC)

Drug: Cabozantinib

13 locations incl. New Haven

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07293351·Phase 1, Phase 2·Recruiting

Apply to this trial

LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis

for Ulcerative Colitis (UC)

Drug: LY4268989

49 locations incl. Phoenix

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07415044·Phase 2·Recruiting

Apply to this trial

A Study to Evaluate the Efficacy and Safety of E2086 in Adults With Narcolepsy

for Narcolepsy

17 locations incl. Santa Ana

Sponsor: Eisai Inc.

Sex: All·Age: 18+

Code: NCT07493265·Phase 2·Recruiting

Apply to this trial

Continuous Dual Aspiration Technique With Zoom System for Stroke

for Ischemic Stroke

13 locations incl. Huntsville

Sponsor: Imperative Care, Inc.

Sex: All·Age: 18+

Code: NCT07491952·Recruiting

Apply to this trial

A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis

for Multiple Sclerosis (MS) Primary Progressive

11 locations incl. Pheonix

Sponsor: Zenas BioPharma (USA), LLC

Sex: All·Age: 18 - 60

Code: NCT07067463·Phase 3·Recruiting

Apply to this trial

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes

for Obesity or Overweight

Drug: Enicepatide

28 locations incl. Guntersville

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT07351058·Phase 3·Recruiting

Apply to this trial

A Study of mRNA-1018-H5 Pandemic Influenza Vaccine in Healthy Adults

for Influenza

10 locations incl. San Bernardino

Sponsor: ModernaTX, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07496450·Phase 3·Recruiting

Apply to this trial

Post Approval Effectiveness and Durability Evaluation of the Altaviva™ Tibial Device

for Urge Urinary Incontinence

5 locations incl. Homewood

Sponsor: MedtronicNeuro

Sex: All·Age: 18+

Code: NCT07456865·Recruiting

Apply to this trial

Advanced Fibrosis Detection for MASLD in Primary Care

for Metabolic Dysfunction-associated Steatotic Liver Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07159386·Recruiting

Apply to this trial

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

for Obesity or Overweight

Drug: Enicepatide

25 locations incl. Anniston

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT07351045·Phase 3·Recruiting

Apply to this trial

Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS)

for Neovascular Age-Related Macular Degeneration (nAMD)

Drug: Ixo-vec

65 locations incl. Phoenix

Sponsor: Adverum Biotechnologies, Inc.

Sex: All·Age: 50+

Code: NCT07482176·Phase 3·Recruiting

Apply to this trial

Brain Stimulation and Cognitive Training for MCI

for Mild Cognitive Impairment (MCI)

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 60 - 85

Code: NCT07526740·Recruiting

Apply to this trial

Train Your Brain Fitness SC: An Exercise Intervention for People With Cognitive Impairments

for Mild-moderate Cognitive Impairment

2 locations incl. Columbia

Sponsor: University of South Carolina

Sex: All·Age: 18+

Code: NCT06799429·Recruiting

Apply to this trial

Cannabis Reduction and Functional Outcomes

for Cannabis Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07218471·Recruiting

Apply to this trial

Long-Term Open-Label Extension Study of Oral Levosimendan

for Pulmonary Hypertension Associated With HFpEF

5 locations incl. Chicago

Sponsor: Tenax Therapeutics, Inc.

Sex: All·Age: All ages

Code: NCT07436689·Phase 3·Enrolling By Invitation

A Study to Find Out if Enfortumab Vedotin Given With Pembrolizumab Helps People With Muscle-invasive Bladder Cancer Keep Their Bladder

for Muscle-invasive Bladder Cancer

9 locations incl. Little Rock

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 18+

Code: NCT07475806·Phase 2·Recruiting

Apply to this trial