Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkersfor Pancreatic Neoplasm408 locations incl. BirminghamSponsor: ECOG-ACRIN Cancer Research GroupSex: All·Age: 50 - 75Code: NCT04239573·RecruitingApply to this trial
Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancerfor Refractory Differentiated Thyroid Gland Carcinoma301 locations incl. AnchorageSponsor: ECOG-ACRIN Cancer Research GroupSex: All·Age: 18+Code: NCT06475989·Phase 3·RecruitingApply to this trial
A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancerfor Ovarian Carcinoma539 locations incl. BirminghamSponsor: NRG OncologySex: Female·Age: 35 - 50Code: NCT04251052·RecruitingApply to this trial
Family Communications After Genetic Testingfor Colon Adenocarcinoma276 locations incl. AnchorageSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+·Accepts healthy volunteersCode: NCT07143487·RecruitingApply to this trial
Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trialfor Advanced Lung Non-Small Cell Carcinoma319 locations incl. FayettevilleSponsor: National Cancer Institute (NCI)Sex: All·Age: 70+Code: NCT06096844·Phase 3·RecruitingApply to this trial
MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)for Acute Myeloid Leukemia336 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT05564390·Phase 2·RecruitingApply to this trial
S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicityfor Cardiotoxicity577 locations incl. AnchorageSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT03418961·Phase 3·RecruitingApply to this trial
Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphomafor Mantle Cell Lymphoma237 locations incl. Little RockSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 60+Code: NCT05976763·Phase 3·RecruitingApply to this trial
Testing Whether High Dose Chemotherapy and Infusion of the Patients' Own Stem Cells Improves Survival in Patients With Peripheral T-cell Lymphoma Who Achieved a Complete Response at the End of the Initial Chemotherapyfor Anaplastic Large Cell Lymphoma, ALK-Negative158 locations incl. BirminghamSponsor: Eastern Cooperative Oncology GroupSex: All·Age: 18 - 75Code: NCT06724237·Phase 3·RecruitingApply to this trial
Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancerfor Advanced Endometrial CarcinomaDrug: Bevacizumab232 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: Female·Age: 18+Code: NCT07198074·Phase 3·RecruitingApply to this trial
Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Changefor Advanced Lung Non-Small Cell CarcinomaDrug: Osimertinib345 locations incl. AnchorageSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT03191149·Phase 2·RecruitingApply to this trial
A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastasesfor Acral Lentiginous MelanomaDrug: Ipilimumab331 locations incl. BirminghamSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT04511013·Phase 2·RecruitingApply to this trial
Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLLfor Chronic Lymphocytic LeukemiaDrug: Sonrotoclax152 locations incl. Los AngelesSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 65+Code: NCT07321652·Phase 3·RecruitingApply to this trial
Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)for Myelodysplastic Syndrome141 locations incl. BerkeleySponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT06577441·Phase 2·RecruitingApply to this trial
Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)for Acute Myeloid LeukemiaDrug: Venetoclax225 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT06317649·Phase 2·RecruitingApply to this trial
Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)for Acute Myeloid Leukemia211 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18 - 59Code: NCT05554406·Phase 2·RecruitingApply to this trial
Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)for Recurrent Lung Non-Small Cell Carcinoma266 locations incl. DaphneSponsor: SWOG Cancer Research NetworkSex: All·Age: 18 Minutes+Code: NCT06031688·Phase 2·RecruitingApply to this trial
Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trialfor Recurrent Endometrial CarcinomaDrug: Selumetinib293 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: Female·Age: 18+Code: NCT05554328·Phase 2·RecruitingApply to this trial
Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)for Malignant Female Reproductive System Neoplasm187 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT06126276·Phase 2·RecruitingApply to this trial
Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)for Acute Myeloid LeukemiaDrug: Venetoclax167 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18 - 59Code: NCT05554393·Phase 2·RecruitingApply to this trial
Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)for Acute Myeloid Leukemia129 locations incl. TucsonSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT06672146·Phase 2·RecruitingApply to this trial
Inotuzumab Ozogamicin and Blinatumomab With or Without Ponatinib in Treating Patients With Newly Diagnosed, Recurrent, or Refractory CD22-Positive B-Lineage Acute Lymphoblastic Leukemiafor B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative276 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT03739814·Phase 2·RecruitingApply to this trial
Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trialfor Muscle Invasive Bladder Urothelial Carcinoma157 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT07061964·Phase 2·RecruitingApply to this trial
Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trialfor Metastatic Castration-Resistant Prostate Carcinoma102 locations incl. AnchorageSponsor: Alliance for Clinical Trials in OncologySex: Male·Age: 18+Code: NCT07200830·Phase 3·RecruitingApply to this trial
Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)for Lung Non-Small Cell Carcinoma248 locations incl. JonesboroSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT06116682·Phase 2·RecruitingApply to this trial
Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphomafor Diffuse Large B-Cell Lymphoma87 locations incl. TucsonSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT05633615·Phase 2·RecruitingApply to this trial
Carboplatin Chemotherapy Before Surgery for People With High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutationfor Prostate Adenocarcinoma133 locations incl. AnchorageSponsor: SWOG Cancer Research NetworkSex: Male·Age: 18+Code: NCT05806515·Phase 2·RecruitingApply to this trial
Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinomafor Endometrial AdenocarcinomaDrug: Ipilimumab137 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: Female·Age: 18+Code: NCT05112601·Phase 2·RecruitingApply to this trial
Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphomafor Lymphoplasmacytic LymphomaDrug: Venetoclax136 locations incl. TucsonSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT04840602·Phase 2·RecruitingApply to this trial
Testing the Effectiveness of a Combination Targeted Therapy (ViPOR) for Patients With Relapsed and/or Refractory Aggressive B-cell Lymphomafor High Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements86 locations incl. TucsonSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT06649812·Phase 2·RecruitingApply to this trial
Testing the Addition of BMS-986016 (Relatlimab) to the Usual Immunotherapy After Initial Treatment for Recurrent or Metastatic Nasopharyngeal Cancerfor Metastatic Nasopharyngeal CarcinomaDrug: Relatlimab83 locations incl. DublinSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT06029270·Phase 2·RecruitingApply to this trial
Testing the Addition of Immunotherapy Before Surgery for Patients With Sarcomatoid Mesotheliomafor Pleural Biphasic Mesothelioma132 locations incl. AnchorageSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT05647265·Phase 2·RecruitingApply to this trial