Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Older Patients With Non-Hodgkin's Lymphoma

Part of paid clinical trials in Mobile, Alabama.

Sponsor
Eastern Cooperative Oncology Group
Study ID
NCT00003150
Phase
PHASE3
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
60 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • rituximab — BIOLOGICAL
  • CHOP regimen — DRUG
  • cyclophosphamide — DRUG
  • doxorubicin hydrochloride — DRUG
  • prednisone — DRUG
  • vincristine sulfate — DRUG

Study Details

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies such as rituximab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. It is not yet known if combination chemotherapy is more effective with or without rituximab for non-Hodgkin's lymphoma. PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy with or without rituximab in treating older patients who have non-Hodgkin's lymphoma.

Key Dates

Start date
Dec 31, 1997
Status verified
Aug 2010
Completion
Sep 30, 2006

Study Design

Enrollment
630 participants (estimated)
Allocation
RANDOMIZED
Primary purpose
TREATMENT

Locations (91)

FacilityCityStateZIPSite coordinators
MBCCOP - Gulf CoastMobileAlabama36688-
CCOP - Greater PhoenixPhoenixArizona85006-2726-
Veterans Affairs Medical Center - Phoenix (Hayden)PhoenixArizona85012-
Arizona Cancer CenterTucsonArizona85724-
Veterans Affairs Medical Center - TucsonTucsonArizona85723-
University of Arkansas for Medical SciencesLittle RockArkansas72205-
Veterans Affairs Medical Center - Little Rock (McClellan)Little RockArkansas72205-
Cancer Center and Beckman Research Institute, City of HopeDuarteCalifornia91010-3000-
Veterans Affairs Medical Center - Long BeachLong BeachCalifornia90822-
Jonsson Comprehensive Cancer Center, UCLALos AngelesCalifornia90095-1781-
USC/Norris Comprehensive Cancer Center and HospitalLos AngelesCalifornia90033-0804-
Veterans Affairs Medical Center - West Los AngelesLos AngelesCalifornia90073-
Veterans Affairs Outpatient Clinic - MartinezMartinezCalifornia94553-
CCOP - Bay Area Tumor InstituteOaklandCalifornia94609-3305-
Chao Family Comprehensive Cancer CenterOrangeCalifornia92868-
University of California Davis Medical CenterSacramentoCalifornia95817-
CCOP - Santa Rosa Memorial HospitalSanta RosaCalifornia95403-
David Grant Medical CenterTravis Air Force BaseCalifornia94535-
University of Colorado Cancer CenterDenverColorado80010-
Veterans Affairs Medical Center - DenverDenverColorado80220-
Hematology Oncology AssociatesAtlantisFlorida33462-
CCOP - Atlanta RegionalAtlantaGeorgia30342-1701-
Dwight David Eisenhower Army Medical CenterFort GordonGeorgia30905-5650-
Cancer Research Center of HawaiiHonoluluHawaii96813-
MBCCOP - University of Illinois at ChicagoChicagoIllinois60612-7323-
CCOP - Central IllinoisDecaturIllinois62526-
Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital)HinesIllinois60141-
Loyola University Medical CenterMaywoodIllinois60153-
University of Kansas Medical CenterKansas CityKansas66160-7357-
CCOP - WichitaWichitaKansas67214-3882-
Veterans Affairs Medical Center - WichitaWichitaKansas67218-
Albert B. Chandler Medical Center, University of KentuckyLexingtonKentucky40536-0084-
Veterans Affairs Medical Center - LexingtonLexingtonKentucky40511-1093-
MBCCOP - LSU Health Sciences CenterNew OrleansLouisiana70112-
Tulane University School of MedicineNew OrleansLouisiana70112-
Louisiana State University Health Sciences Center - ShreveportShreveportLouisiana71130-3932-
Veterans Affairs Medical Center - ShreveportShreveportLouisiana71130-
Boston Medical CenterBostonMassachusetts02118-
Veterans Affairs Medical Center - Boston (Jamaica Plain)Jamaica PlainMassachusetts02130-
CCOP - Ann Arbor RegionalAnn ArborMichigan48106-
University of Michigan Comprehensive Cancer CenterAnn ArborMichigan48109-0752-
Veterans Affairs Medical Center - Ann ArborAnn ArborMichigan48105-
Barbara Ann Karmanos Cancer InstituteDetroitMichigan48201-1379-
Henry Ford HospitalDetroitMichigan48202-
Veterans Affairs Medical Center - DetroitDetroitMichigan48201-1932-
CCOP - Grand Rapids Clinical Oncology ProgramGrand RapidsMichigan49503-
Providence Hospital - SouthfieldSouthfieldMichigan48075-9975-
CCOP - DuluthDuluthMinnesota55805-
Veterans Affairs Medical Center - BiloxiBiloxiMississippi39531-2410-
University of Mississippi Medical CenterJacksonMississippi39216-4505-
Veterans Affairs Medical Center - JacksonJacksonMississippi39216-
Keesler Medical Center - Keesler AFBKeesler Air Force BaseMississippi39534-2576-
CCOP - Kansas CityKansas CityMissouri64131-
Veterans Affairs Medical Center - Kansas CityKansas CityMissouri64128-
CCOP - Cancer Research for the OzarksSpringfieldMissouri65807-
CCOP - St. Louis-Cape GirardeauSt LouisMissouri63141-
St. Louis University Health Sciences CenterSt LouisMissouri63110-0250-
CCOP - Montana Cancer ConsortiumBillingsMontana59101-
MBCCOP - University of New Mexico HSCAlbuquerqueNew Mexico87131-
Veterans Affairs Medical Center - AlbuquerqueAlbuquerqueNew Mexico87108-5138-
Herbert Irving Comprehensive Cancer CenterNew YorkNew York10032-
CCOP - Southeast Cancer Control ConsortiumWinston-SalemNorth Carolina27104-4241-
Barrett Cancer Center, The University HospitalCincinnatiOhio45219-
Veterans Affairs Medical Center - CincinnatiCincinnatiOhio45220-2288-
Cleveland Clinic Taussig Cancer CenterClevelandOhio44195-
CCOP - ColumbusColumbusOhio43206-
Veterans Affairs Medical Center - DaytonDaytonOhio45428-
CCOP - DaytonKetteringOhio45429-
CCOP - Toledo Community Hospital Oncology ProgramToledoOhio43623-3456-
University of Oklahoma Health Sciences CenterOklahoma CityOklahoma73190-
Veterans Affairs Medical Center - Oklahoma CityOklahoma CityOklahoma73104-
CCOP - Columbia River ProgramPortlandOregon97213-
Oregon Cancer CenterPortlandOregon97201-3098-
Veterans Affairs Medical Center - PortlandPortlandOregon97207-
CCOP - GreenvilleGreenvilleSouth Carolina29615-
CCOP - Upstate CarolinaSpartanburgSouth Carolina29303-
Simmons Cancer Center - DallasDallasTexas75235-9154-
Brooke Army Medical CenterFort Sam HoustonTexas78234-
University of Texas Medical BranchGalvestonTexas77555-0209-
Texas Tech University Health Science CenterLubbockTexas79423-
University of Texas Health Science Center at San AntonioSan AntonioTexas78284-7811-
Veterans Affairs Medical Center - San Antonio (Murphy)San AntonioTexas78284-
CCOP - Scott and White HospitalTempleTexas76508-
Veterans Affairs Medical Center - TempleTempleTexas76504-
Huntsman Cancer InstituteSalt Lake CityUtah84112-
Veterans Affairs Medical Center - Salt Lake CitySalt Lake CityUtah84148-
CCOP - Virginia Mason Research CenterSeattleWashington98101-
Swedish Cancer InstituteSeattleWashington98104-
Veterans Affairs Medical Center - SeattleSeattleWashington98108-
CCOP - NorthwestTacomaWashington98405-0986-
Madigan Army Medical CenterTacomaWashington98431-5000-

Find similar trials in Mobile, AL

By research site
MBCCOP - Gulf Coast· Mobile, ALCCOP - Greater Phoenix· Phoenix, AZVeterans Affairs Medical Center - Phoenix (Hayden)· Phoenix, AZArizona Cancer Center· Tucson, AZVeterans Affairs Medical Center - Tucson· Tucson, AZUniversity of Arkansas for Medical Sciences· Little Rock, AR

Related Studies