Monoclonal Antibody Therapy and Combination Chemotherapy in Treating Patients With Stage II, Stage III, or Stage IV Diffuse Large B-Cell Lymphoma

Part of paid clinical trials in Scottsdale, Arizona.

Sponsor
Alliance for Clinical Trials in Oncology
Study ID
NCT00301821
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • epratuzumab — BIOLOGICAL
  • rituximab — BIOLOGICAL
  • cyclophosphamide — DRUG
  • doxorubicin hydrochloride — DRUG
  • prednisone — DRUG
  • vincristine sulfate — DRUG

Study Details

RATIONALE: Monoclonal antibodies, such as epratuzumab and rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin, vincristine, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving monoclonal antibody therapy together with chemotherapy may kill more cancer cells.\> PURPOSE: This phase II trial is studying how well giving monoclonal antibody therapy together with combination chemotherapy works in treating patients with stage II, stage III, or stage IV diffuse large B-cell lymphoma.

Key Dates

Start date
Jan 31, 2006
Status verified
Oct 2019
Primary completion
Oct 31, 2008
Completion
Apr 30, 2015

Study Design

Enrollment
107 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Epratuzumab + Rituximab + CHOP
    One arm open label.

Primary Outcome Measure

Event-free Survival After 12 Months [ Time Frame: From Baseline to 12 months ]

Locations (162)

FacilityCityStateZIPSite coordinators
Mayo Clinic ScottsdaleScottsdaleArizona85259-5499-
Aurora Presbyterian HospitalAuroraColorado80012-
Boulder Community HospitalBoulderColorado80301-9019-
Penrose Cancer Center at Penrose HospitalColorado SpringsColorado80933-
CCOP - Colorado Cancer Research ProgramDenverColorado80224-2522-
Porter Adventist HospitalDenverColorado80210-
Presbyterian - St. Luke's Medical CenterDenverColorado80218-
Rose Medical CenterDenverColorado80220-
St. Joseph HospitalDenverColorado80218-
Swedish Medical CenterEnglewoodColorado80110-
Front Range Cancer SpecialistsFort CollinsColorado80524-
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical CenterGrand JunctionColorado81502-
Sky Ridge Medical CenterLone TreeColorado80124-
Hope Cancer Care Center at Longmont United HospitalLongmontColorado80502-
St. Mary - Corwin Regional Medical CenterPuebloColorado81004-
North Suburban Medical CenterThorntonColorado80229-
Exempla Lutheran Medical CenterWheat RidgeColorado80033-
Mayo Clinic - JacksonvilleJacksonvilleFlorida32224-
Rush-Copley Cancer Care CenterAuroraIllinois60507-
St. Joseph Medical CenterBloomingtonIllinois61701-
Graham HospitalCantonIllinois61520-
Memorial HospitalCarthageIllinois62321-
Eureka Community HospitalEurekaIllinois61530-
Galesburg ClinicGalesburgIllinois61401-
Galesburg Cottage HospitalGalesburgIllinois61401-
Mason District HospitalHavanaIllinois62644-
Hopedale Medical ComplexHopedaleIllinois61747-
Joliet Oncology-Hematology Associates, Limited - WestJolietIllinois60435-
Kewanee HospitalKewaneeIllinois61443-
McDonough District HospitalMacombIllinois61455-
-MolineIllinois61265-
Trinity Medical Center - EastMolineIllinois61265-
BroMenn Regional Medical CenterNormalIllinois61761-
Community Cancer CenterNormalIllinois61761-
Community Hospital of OttawaOttawaIllinois61350-
Oncology Hematology Associates of Central Illinois, PC - OttawaOttawaIllinois61350-
Cancer Treatment Center at Pekin HospitalPekinIllinois61554-
CCOP - Illinois Oncology Research AssociationPeoriaIllinois61615-
Methodist Medical Center of IllinoisPeoriaIllinois61636-
Oncology Hematology Associates of Central Illinois, PC - PeoriaPeoriaIllinois61615-
OSF St. Francis Medical CenterPeoriaIllinois61637-
Proctor HospitalPeoriaIllinois61614-
Illinois Valley Community HospitalPeruIllinois61354-
Perry Memorial HospitalPrincetonIllinois61356-
St. Margaret's HospitalSpring ValleyIllinois61362-
Carle Cancer Center at Carle Foundation HospitalUrbanaIllinois61801-
CCOP - Carle Cancer CenterUrbanaIllinois61801-
St. Francis Hospital and Health Centers - Beech Grove CampusBeech GroveIndiana46107-
Saint Anthony Memorial Health CentersMichigan CityIndiana46360-
Reid Hospital & Health Care Services, IncorporatedRichmondIndiana47374-
McFarland Clinic, PCAmesIowa50010-
CCOP - Iowa Oncology Research AssociationDes MoinesIowa50309-
John Stoddard Cancer CenterDes MoinesIowa50316-2301-
John Stoddard Cancer Center at Iowa Methodist Medical CenterDes MoinesIowa50309-
Medical Oncology and Hematology Associates at John Stoddard Cancer CenterDes MoinesIowa50309-
Medical Oncology and Hematology Associates at Mercy Cancer CenterDes MoinesIowa50314-
Mercy Cancer Center at Mercy Medical Center - Des MoinesDes MoinesIowa50314-
Mercy Capitol HospitalDes MoinesIowa50307-
Mercy Cancer Center at Mercy Medical Center - North IowaMason CityIowa50401-
Mercy Medical Center - Sioux CitySioux CityIowa51104-
Siouxland Hematology-Oncology Associates, LLPSioux CityIowa51101-
St. Luke's Regional Medical CenterSioux CityIowa51104-
Cancer Center of Kansas, PA - ChanuteChanuteKansas66720-
Cancer Center of Kansas, PA - Dodge CityDodge CityKansas67801-
Cancer Center of Kansas, PA - El DoradoEl DoradoKansas67042-
Cancer Center of Kansas, PA - KingmanKingmanKansas67068-
Southwest Medical CenterLiberalKansas67901-
Cancer Center of Kansas, PA - NewtonNewtonKansas67114-
Cancer Center of Kansas, PA - ParsonsParsonsKansas67357-
Cancer Center of Kansas, PA - PrattPrattKansas67124-
Cancer Center of Kansas, PA - SalinaSalinaKansas67042-
Cancer Center of Kansas, PA - WellingtonWellingtonKansas67152-
Associates in Womens Health, PA - North ReviewWichitaKansas67203-
Cancer Center of Kansas, PA - Medical Arts TowerWichitaKansas67208-
Cancer Center of Kansas, PA - WichitaWichitaKansas67214-
CCOP - WichitaWichitaKansas67214-
Via Christi Cancer Center at Via Christi Regional Medical CenterWichitaKansas67214-
Cancer Center of Kansas, PA - WinfieldWinfieldKansas67156-
Hickman Cancer Center at Bixby Medical CenterAdrianMichigan49221-
Haematology-Oncology Associates of Ohio and Michigan, PCLambertvilleMichigan48144-
Community Cancer Center of MonroeMonroeMichigan48162-
Mercy Memorial Hospital - MonroeMonroeMichigan48162-
-AlexandriaMinnesota56308-
MeritCare BemidjiBemidjiMinnesota56601-
Fairview Ridges HospitalBurnsvilleMinnesota55337-
Mercy and Unity Cancer Center at Mercy HospitalCoon RapidsMinnesota55433-
CCOP - DuluthDuluthMinnesota55805-
Duluth Clinic Cancer Center - DuluthDuluthMinnesota55805-1983-
Miller - Dwan Medical CenterDuluthMinnesota55805-
Fairview Southdale HospitalEdinaMinnesota55435-
-Fergus FallsMinnesota56537-
Mercy and Unity Cancer Center at Unity HospitalFridleyMinnesota55432-
Hutchinson Area Health CareHutchinsonMinnesota55350-
Meeker County Memorial HospitalLitchfieldMinnesota55355-
HealthEast Cancer Care at St. John's HospitalMaplewoodMinnesota55109-
Minnesota Oncology Hematology, PA - MaplewoodMaplewoodMinnesota55109-
Hennepin County Medical Center - MinneapolisMinneapolisMinnesota55415-
Virginia Piper Cancer Institute at Abbott - Northwestern HospitalMinneapolisMinnesota55407-
Chippewa County - Montevideo Hospital and Medical CenterMontevideoMinnesota56265-
Hubert H. Humphrey Cancer Center at North Memorial Outpatient CenterRobbinsdaleMinnesota55422-2900-
Mayo Clinic Cancer CenterRochesterMinnesota55905-
CentraCare Clinic - River CampusSaint CloudMinnesota56303-
Coborn Cancer CenterSaint CloudMinnesota56303-
CCOP - Metro-MinnesotaSaint Louis ParkMinnesota55416-
Park Nicollet Cancer CenterSaint Louis ParkMinnesota55416-
HealthEast Cancer Care at St. Joseph's HospitalSaint PaulMinnesota55102-
Regions Hospital Cancer Care CenterSaint PaulMinnesota55101-
United HospitalSaint PaulMinnesota55102-
St. Francis Cancer Center at St. Francis Medical CenterShakopeeMinnesota55379-
Ridgeview Medical CenterWaconiaMinnesota55387-
HealthEast Cancer Care at Woodwinds Health CampusWoodburyMinnesota55125-
Minnesota Oncology Hematology, PA - WoodburyWoodburyMinnesota55125-
Cancer Resource Center - LincolnLincolnNebraska68510-
Alegant Health Cancer Center at Bergan Mercy Medical CenterOmahaNebraska68124-
CCOP - Missouri Valley Cancer ConsortiumOmahaNebraska68106-
Creighton University Medical CenterOmahaNebraska68131-2197-
Immanuel Medical CenterOmahaNebraska68122-
Rutherford HospitalRutherfordtonNorth Carolina28139-
Bismarck Cancer CenterBismarckNorth Dakota58501-
Medcenter One Hospital Cancer Care CenterBismarckNorth Dakota58501-
Mid Dakota Clinic, PCBismarckNorth Dakota58501-
St. Alexius Medical Center Cancer CenterBismarckNorth Dakota58502-
CCOP - MeritCare HospitalFargoNorth Dakota58122-
MeritCare BroadwayFargoNorth Dakota58122-
Wood County Oncology CenterBowling GreenOhio43402-
CCOP - DaytonDaytonOhio45429-
David L. Rike Cancer Center at Miami Valley HospitalDaytonOhio45409-
Good Samaritan HospitalDaytonOhio45406-
Grandview HospitalDaytonOhio45405-
Samaritan North Cancer Care CenterDaytonOhio45415-
Veterans Affairs Medical Center - DaytonDaytonOhio45428-
Blanchard Valley Medical AssociatesFindlayOhio45840-
Fremont Memorial HospitalFremontOhio43420-
Charles F. Kettering Memorial HospitalKetteringOhio45429-
Lima Memorial HospitalLimaOhio45804-
Northwest Ohio Oncology CenterMaumeeOhio43537-
St. Luke's HospitalMaumeeOhio43537-
Middletown Regional HospitalMiddletownOhio45044-
St. Charles Mercy HospitalOregonOhio43616-
Toledo Clinic - OregonOregonOhio43616-
Firelands Regional Medical CenterSanduskyOhio44870-
North Coast Cancer Care, IncorporatedSanduskyOhio44870-
Flower Hospital Cancer CenterSylvaniaOhio43560-
Mercy Hospital of TiffinTiffinOhio44883-
CCOP - Toledo Community HospitalToledoOhio43617-
Medical University of Ohio Cancer CenterToledoOhio43614-
St. Vincent Mercy Medical CenterToledoOhio43608-
Toledo Clinic, Incorporated - Main ClinicToledoOhio43623-
Toledo HospitalToledoOhio43606-
UVMC Cancer Care Center at Upper Valley Medical CenterTroyOhio45373-1300-
Fulton County Health CenterWauseonOhio43567-
Ruth G. McMillan Cancer Center at Greene Memorial HospitalXeniaOhio45385-
Natalie Warren Bryant Cancer Center at St. Francis HospitalTulsaOklahoma74136-
Morgan Cancer Center at Lehigh Valley Hospital - Cedar CrestAllentownPennsylvania18105-
AnMed Cancer CenterAndersonSouth Carolina29621-
CCOP - Upstate CarolinaSpartanburgSouth Carolina29303-
Gibbs Regional Cancer Center at Spartanburg Regional Medical CenterSpartanburgSouth Carolina29303-
Avera Cancer InstituteSioux FallsSouth Dakota57105-
Medical X-Ray Center, PCSioux FallsSouth Dakota57105-
Sanford Cancer Center at Sanford USD Medical CenterSioux FallsSouth Dakota57117-5039-
Hematology-Oncology Associates of Fredericksburg, IncorporatedFredericksburgVirginia22401-
Franciscan Skemp Healthcare - La Crosse CampusLa CrosseWisconsin54601-

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