Radiation Therapy, Chemotherapy, and Bevacizumab in Treating Patients With Recurrent, Unresectable or Stage III or Stage IV Non-Small Cell Lung Cancer

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Northwestern University
Study ID
NCT00334763
Phase
PHASE2
Status
Terminated

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • bevacizumab — BIOLOGICAL
  • carboplatin — DRUG
  • chemoprotection — DRUG
  • paclitaxel — DRUG
  • radiation therapy — RADIATION

Study Details

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Giving radiation therapy together with chemotherapy and monoclonal antibody therapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving radiation therapy together with chemotherapy and bevacizumab works in treating patients with recurrent, unresectable or stage III or stage IV non-small cell lung cancer.

Key Dates

First listed
Jun 8, 2006
Start date
May 31, 2006
Status verified
Jul 2012
Primary completion
May 31, 2007
Completion
Nov 30, 2007

Study Design

Enrollment
32 participants (estimated)
Primary purpose
TREATMENT

Primary Outcome Measure

Reduction in toxicity measured by pulmonary hemorrhage rate

Locations (5)

FacilityCityStateZIPSite coordinators
Lurleen Wallace Comprehensive Cancer at University of Alabama - BirminghamBirminghamAlabama35294-
Robert H. Lurie Comprehensive Cancer Center at Northwestern UniversityChicagoIllinois60611-3013-
Evanston Northwestern Healthcare - Evanston HospitalEvanstonIllinois60201-1781-
Vanderbilt-Ingram Cancer CenterNashvilleTennessee37232-6838-
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - DallasDallasTexas75390-

Find similar trials in Birmingham, AL

By condition
Lung cancer
By specialty
OncologyLung oncologyLung disease
By research site
Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham· Birmingham, ALRobert H. Lurie Comprehensive Cancer Center at Northwestern University· Chicago, ILEvanston Northwestern Healthcare - Evanston Hospital· Evanston, ILVanderbilt-Ingram Cancer Center· Nashville, TNSimmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas· Dallas, TX

Related Studies