VEGF Trap in Treating Patients With Recurrent Malignant Gliomas That Did Not Respond to Temozolomide

Part of paid clinical trials in Los Angeles, California.

Sponsor
National Cancer Institute (NCI)
Study ID
NCT00369590
Phase
PHASE2
Status
Completed

Conditions

  • Adult Anaplastic Astrocytoma
  • Adult Anaplastic Oligodendroglioma
  • Adult Giant Cell Glioblastoma
  • Adult Gliosarcoma
  • Recurrent Adult Brain Tumor

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • ziv-aflibercept — BIOLOGICAL
    Given IV
  • pharmacological study — OTHER
    correlative studies
  • laboratory biomarker analysis — OTHER
    correlative studies

Study Details

This phase II trial is studying how well VEGF Trap works in treating patients with recurrent malignant or anaplastic gliomas that did not respond to temozolomide. VEGF Trap may stop the growth of malignant or anaplastic gliomas by blocking blood flow to the tumor.

Key Dates

Start date
Aug 31, 2006
Status verified
Aug 2015
Primary completion
Dec 31, 2011
Completion
Oct 31, 2012

Study Design

Enrollment
58 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: All Study Patients
    Patients receive VEGF Trap (ziv-aflibercept) IV over 1 hour on day 1. Treatment repeats every 14 days in the absence of disease progression or unacceptable toxicity. Other: pharmacological study; laboratory biomarker analysis.

Primary Outcome Measure

Progression-free Survival (PFS) at 6 Months [ Time Frame: 6 months ]

Locations (7)

FacilityCityStateZIPSite coordinators
University of California Los AngelesLos AngelesCalifornia90095-
University of California San FranciscoSan FranciscoCalifornia94115-
Dana-Farber Cancer InstituteBostonMassachusetts02115-
Memorial Sloan-Kettering Cancer CenterNew YorkNew York10065-
University of PittsburghPittsburghPennsylvania15232-
M D Anderson Cancer CenterHoustonTexas77030-
University of Wisconsin Hospital and ClinicsMadisonWisconsin53792-

Find similar trials in Los Angeles, CA

By research site
University of California Los Angeles· Los Angeles, CAUniversity of California San Francisco· San Francisco, CADana-Farber Cancer Institute· Boston, MAMemorial Sloan-Kettering Cancer Center· New York, NYUniversity of Pittsburgh· Pittsburgh, PAM D Anderson Cancer Center· Houston, TX

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