Phase 2 Study of Rituximab-ABVD in Classical Hodgkin Lymphoma

Part of paid clinical trials in Duarte, California.

Sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Study ID
NCT00369681
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 120 Years
Healthy Volunteers
Not accepted

Interventions

  • Bleomycin — DRUG
  • Rituximab — BIOLOGICAL
  • Dacarbazine — DRUG
  • Doxorubicin — DRUG
  • Vinblastine — DRUG

Study Details

RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving rituximab together with combination chemotherapy may kill more cancer cells. PURPOSE: This phase II trial is studying how well giving rituximab together with combination chemotherapy works in treating patients with newly diagnosed stage II, stage III, or stage IV Hodgkin's lymphoma.

Key Dates

Start date
May 31, 2006
Status verified
Jul 2018
Primary completion
Oct 31, 2014
Completion
Oct 31, 2014

Study Design

Enrollment
51 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: R-ABVD
    ABVD (doxorubicin; vinblastine; bleomycin; dacarbazine) given as standard for 6-8 cycles. Rituximab given 375 mg/m\^2 Cycle 1 Days -6, 1, 8, 15, and 22. Rituximab given 375 mg/m\^2 Cycles 2, 4, and 6 Day 1.

Primary Outcome Measure

Effect of Rituximab on EBV(+) Tumors [ Time Frame: Up to 56 months ]

Locations (4)

FacilityCityStateZIPSite coordinators
City of Hope Comprehensive Cancer CenterDuarteCalifornia91010-3000-
Holden Comprehensive Cancer Center at University of IowaIowa CityIowa52242-1009-
Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsBaltimoreMaryland21231-2410-
Mayo Clinic Cancer CenterRochesterMinnesota55905-

Find similar trials in Duarte, CA

By research site
City of Hope Comprehensive Cancer Center· Duarte, CAHolden Comprehensive Cancer Center at University of Iowa· Iowa City, IASidney Kimmel Comprehensive Cancer Center at Johns Hopkins· Baltimore, MDMayo Clinic Cancer Center· Rochester, MN

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