VEGF Trap in Treating Patients With Recurrent or Persistent Endometrial Cancer

Part of paid clinical trials in Hartford, Connecticut.

Sponsor
National Cancer Institute (NCI)
Study ID
NCT00462826
Phase
PHASE2
Status
Completed

Conditions

  • Recurrent Endometrial Carcinoma

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

This phase II trial is studying the side effects and how well VEGF Trap works in treating patients with recurrent or persistent endometrial cancer. VEGF Trap may stop the growth of endometrial cancer by blocking blood flow to the tumor and by carrying tumor-killing substances directly to endometrial cancer cells.

Key Dates

Start date
Nov 30, 2007
Status verified
Jul 2019
Primary completion
Jan 31, 2013
Completion
Jan 31, 2013

Study Design

Enrollment
49 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment (aflibercept)
    Patients receive VEGF Trap IV over 1 hour on days 1 and 15. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.

Primary Outcome Measure

6 Month Progression-free Survival [ Time Frame: At 6 monthsEvery other cycle during treatment for the first 6 months. ]

Locations (67)

FacilityCityStateZIPSite coordinators
Hartford HospitalHartfordConnecticut06102-
The Hospital of Central ConnecticutNew BritainConnecticut06050-
Washington Hospital CenterWashington D.C.District of Columbia20010-
Jupiter Medical CenterJupiterFlorida33458-
Florida HospitalOrlandoFlorida32803-
Memorial Health University Medical CenterSavannahGeorgia31403-
Northwestern UniversityChicagoIllinois60611-
University of ChicagoChicagoIllinois60637-
University of IllinoisChicagoIllinois60612-
Saint Vincent Hospital and Health ServicesIndianapolisIndiana46260-
University of Iowa Hospitals and ClinicsIowa CityIowa52242-
Providence Medical CenterKansas CityKansas66112-
Lawrence Memorial HospitalLawrenceKansas66044-
Radiation Oncology Center of OlatheOlatheKansas66061-
Menorah Medical CenterOverland ParkKansas66209-
Radiation Oncology Practice Corporation SouthwestOverland ParkKansas66210-
Shawnee Mission Medical CenterShawnee MissionKansas66204-
Franklin Square Hospital CenterBaltimoreMaryland21237-
Johns Hopkins University/Sidney Kimmel Cancer CenterBaltimoreMaryland21287-
Massachusetts General Hospital Cancer CenterBostonMassachusetts02114-
Green Bay Oncology - EscanabaEscanabaMichigan49431-
Green Bay Oncology - Iron MountainIron MountainMichigan49801-
Centerpoint Medical Center LLCIndependenceMissouri64057-
North Kansas City HospitalKansas CityMissouri64116-
Radiation Oncology Practice Corporation - NorthKansas CityMissouri64154-
Radiation Oncology Practice Corporation SouthKansas CityMissouri64114-
Research Medical CenterKansas CityMissouri64132-
Saint Joseph Health CenterKansas CityMissouri64114-
Saint Luke's Cancer InstituteKansas CityMissouri64111-
Saint Luke's Hospital of Kansas CityKansas CityMissouri64111-
Truman Medical CenterKansas CityMissouri64108-
Liberty HospitalLibertyMissouri64068-
Heartland Regional Medical CenterSaint JosephMissouri64506-
Washington University School of MedicineSt LouisMissouri63110-
Cooper Hospital University Medical CenterCamdenNew Jersey08103-
Southwest Gynecologic Oncology Associates IncAlbuquerqueNew Mexico87106-
University of New Mexico Cancer CenterAlbuquerqueNew Mexico87106-
Stony Brook University Medical CenterStony BrookNew York11794-
Novant Health Presbyterian Medical CenterCharlotteNorth Carolina28204-
Gynecologic Oncology NetworkGreenvilleNorth Carolina27834-
Wake Forest University Health SciencesWinston-SalemNorth Carolina27157-
Case Western Reserve UniversityClevelandOhio44106-
Cleveland Clinic Cancer Center/Fairview HospitalClevelandOhio44111-
Cleveland Clinic FoundationClevelandOhio44195-
MetroHealth Medical CenterClevelandOhio44109-
Mount Carmel Health Center WestColumbusOhio43222-
Riverside Methodist HospitalColumbusOhio43214-
Miami Valley HospitalDaytonOhio45409-
Hillcrest Hospital Cancer CenterMayfield HeightsOhio44124-
Lake University Ireland Cancer CenterMentorOhio44060-
University of Oklahoma Health Sciences CenterOklahoma CityOklahoma73104-
Cancer Care Associates-MidtownTulsaOklahoma74104-
Tulsa Cancer InstituteTulsaOklahoma74146-
Abington Memorial HospitalAbingtonPennsylvania19001-
Women and Infants HospitalProvidenceRhode Island02905-
M D Anderson Cancer CenterHoustonTexas77030-
Carilion Clinic Gynecological OncologyRoanokeVirginia24016-
Fred Hutchinson Cancer Research Center/University of Washington Cancer ConsortiumSeattleWashington98109-
University of Washington Medical CenterSeattleWashington98195-
Northwest Medical Specialties PLLCTacomaWashington98405-
Green Bay Oncology at Saint Vincent HospitalGreen BayWisconsin54301-3526-
Green Bay Oncology Limited at Saint Mary's HospitalGreen BayWisconsin54303-
Saint Mary's HospitalGreen BayWisconsin54303-
Saint Vincent HospitalGreen BayWisconsin54301-
University of Wisconsin Hospital and ClinicsMadisonWisconsin53792-
Green Bay Oncology - Oconto FallsOconto FallsWisconsin54154-
Green Bay Oncology - Sturgeon BaySturgeon BayWisconsin54235-

Find similar trials in Hartford, CT

By research site
Hartford Hospital· Hartford, CTThe Hospital of Central Connecticut· New Britain, CTWashington Hospital Center· Washington D.C., DCJupiter Medical Center· Jupiter, FLFlorida Hospital· Orlando, FLMemorial Health University Medical Center· Savannah, GA

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