Erlotinib and SBRT in Treating Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Part of paid clinical trials in Aurora, Colorado.

Sponsor
University of Texas Southwestern Medical Center
Study ID
NCT00547105
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 120 Years
Healthy Volunteers
Not accepted

Interventions

  • Erlotinib — DRUG
    Erlotinib is indicated for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) after failure of at least one prior chemotherapy regimen.
  • SBRT — RADIATION
    SBRT is a treatment method to deliver a high dose of radiation to the target, utilizing either a single dose or a small number of fractions with a high degree of precision within the body

Study Details

RATIONALE: Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Stereotactic body radiation therapy may be able to send x-rays directly to the tumor and cause less damage to normal tissue. Giving erlotinib together with stereotactic body radiation therapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving erlotinib together with stereotactic body radiation therapy works in treating patients with locally advanced or metastatic non-small cell lung cancer.

Key Dates

First listed
Oct 22, 2007
Start date
Jun 25, 2007
Status verified
Apr 2018
Primary completion
Jul 6, 2016
Completion
Jul 6, 2017

Study Design

Enrollment
24 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: erlotinib in combination with SBRT
    Patients enrolled on the trial will have been receiving or will begin to receive erlotinib at standard doses (150 mg po per day). SBRT will commence within 4 weeks of the initiation of erlotinib

Primary Outcome Measure

6 Month Progression-Free Survival [ Time Frame: 6 months ]

Locations (2)

FacilityCityStateZIPSite coordinators
University of Colorado Cancer Center at UC Health Sciences CenterAuroraColorado80045-
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - DallasDallasTexas75390-

Find similar trials in Aurora, CO

By condition
Lung cancer
By specialty
OncologyLung oncologyLung disease
By research site
University of Colorado Cancer Center at UC Health Sciences Center· Aurora, COSimmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas· Dallas, TX

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