Study of Oral Topotecan With Bevacizumab for Recurrent Small Cell Lung Cancer

Part of paid clinical trials in Jonesboro, Arkansas.

Sponsor
GlaxoSmithKline
Study ID
NCT00698516
Phase
PHASE2
Status
Completed

Conditions

  • Lung Cancer, Small Cell
  • Recurrent Small-cell Lung Cancer (SCLC)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

Combination of Hycamtin (topotecan) and Avastin (bevacizumab) could allow killing of both endothelial and neoplastic cells. We postulate that addition of bevacizumab to topotecan will increase delivery of topotecan to tumor cells and may enhance activity of topotecan in patients with previously treated small cell lung cancer and improve progression free survival.

Key Dates

First listed
Jun 17, 2008
Start date
Jul 31, 2008
Status verified
Mar 2011
Primary completion
May 31, 2010
Completion
May 31, 2010

Study Design

Enrollment
50 participants (actual)
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Open label, Single arm
    Oral topotecan + IV Bevacizumab

Primary Outcome Measure

Percentage of Participants With Progression-free Survival (PFS) at 3 Months [ Time Frame: 3 months ]

Locations (16)

FacilityCityStateZIPSite coordinators
GSK Investigational SiteJonesboroArkansas72401-
GSK Investigational SiteGainesvilleFlorida32605-
GSK Investigational SiteNaplesFlorida34119-
GSK Investigational SiteAthensGeorgia30607-
GSK Investigational SiteMaconGeorgia31201-
GSK Investigational SiteMariettaGeorgia30060-
GSK Investigational SiteJacksonMississippi39202-
GSK Investigational SiteCincinnatiOhio45236-
GSK Investigational SiteMt. PleasantSouth Carolina29464-
GSK Investigational SiteChattanoogaTennessee37404-
GSK Investigational SiteMemphisTennessee38104-
GSK Investigational SiteMemphisTennessee38120-
GSK Investigational SiteNashvilleTennessee37203-
GSK Investigational SiteFort WorthTexas76104-
GSK Investigational SiteSeattleWashington98101-2795-
GSK Investigational SiteMadisonWisconsin53792-

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