Bevacizumab and Erlotinib After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma

Part of paid clinical trials in Los Angeles, California.

Sponsor
Northwestern University
Study ID
NCT00720356
Phase
PHASE2
Status
Completed

Conditions

  • Brain and Central Nervous System Tumors

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving bevacizumab together with erlotinib may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving bevacizumab together with erlotinib works after radiation therapy and temozolomide in treating patients with newly diagnosed glioblastoma multiforme or gliosarcoma.

Key Dates

First listed
Jul 22, 2008
Start date
Jul 7, 2009
Status verified
Oct 2018
Primary completion
Jun 24, 2014
Completion
Jul 5, 2018

Study Design

Enrollment
115 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment
    erlotinib and bevacizumab

Primary Outcome Measure

Overall Survival [ Time Frame: From start of treatment, during treatment and every 3 months following the end of treatment until death. Median follow up at time of OS data was 33 months. ]

Locations (9)

FacilityCityStateZIPSite coordinators
Cedars-Sinai Medical CenterLos AngelesCalifornia90048-
M.D. Anderson Cancer Center at OrlandoOrlandoFlorida32806-2134-
Northwestern University, Northwestern Medical Faculty FoundationChicagoIllinois60611-3013-
Evanston HospitalEvanstonIllinois60201-1781-
Hollings Cancer Center at Medical University of South CarolinaCharlestonSouth Carolina29425-
Neuro-Oncology Associates at Baylor University Medical Center, DallasDallasTexas75246-
M.D. Anderson Cancer Center at University of TexasHoustonTexas77030-4009-
The Methodist Hospital Neurological InstituteHoustonTexas77030-
Fred Hutchinson Cancer Research Center/University of Washington Cancer ConsortiumSeattleWashington19024-

Find similar trials in Los Angeles, CA

By research site
Cedars-Sinai Medical Center· Los Angeles, CAM.D. Anderson Cancer Center at Orlando· Orlando, FLNorthwestern University, Northwestern Medical Faculty Foundation· Chicago, ILEvanston Hospital· Evanston, ILHollings Cancer Center at Medical University of South Carolina· Charleston, SCNeuro-Oncology Associates at Baylor University Medical Center, Dallas· Dallas, TX

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