Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary

Part of paid clinical trials in Los Angeles, California.

Sponsor
National Cancer Institute (NCI)
Study ID
NCT00748657
Phase
PHASE2
Status
Completed

Conditions

  • Malignant Ovarian Epithelial Tumor
  • Ovarian Granulosa Cell Tumor
  • Ovarian Gynandroblastoma
  • Ovarian Sertoli-Leydig Cell Tumor
  • Ovarian Sex Cord Tumor With Annular Tubules
  • Ovarian Sex Cord-Stromal Tumor
  • Ovarian Sex Cord-Stromal Tumor of Mixed or Unclassified Cell Types
  • Ovarian Steroid Cell Tumor

Eligibility Criteria

Sex
FEMALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Bevacizumab — BIOLOGICAL
    Given IV
  • Laboratory Biomarker Analysis — OTHER
    Correlative studies

Study Details

This phase II trial studies how well bevacizumab works in treating patients with sex cord-stromal tumors of the ovary that have come back. Monoclonal antibodies, such as bevacizumab, may block tumor growth in different ways by targeting certain cells. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor.

Key Dates

First listed
Sep 8, 2008
Start date
Sep 22, 2008
Status verified
Jul 2019
Primary completion
Jan 31, 2013
Completion
Jan 31, 2013

Study Design

Enrollment
36 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment (bevacizumab)
    Patients receive bevacizumab IV over 30-90 minutes on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Primary Outcome Measure

Tumor Response [ Time Frame: Every other cycle for 6 months; then every 3 months for two years; then every six months for three years; and at any other time if clinically indicated based on symptoms, physical signs suggestive of progressive disease or rising serum tumor maker levels ]

Locations (36)

FacilityCityStateZIPSite coordinators
Los Angeles County-USC Medical CenterLos AngelesCalifornia90033-
USC / Norris Comprehensive Cancer CenterLos AngelesCalifornia90033-
University of Colorado HospitalAuroraColorado80045-
Hartford HospitalHartfordConnecticut06102-
The Hospital of Central ConnecticutNew BritainConnecticut06050-
Northeast Georgia Medical Center-GainesvilleGainesvilleGeorgia30501-
Northwestern UniversityChicagoIllinois60611-
University of Chicago Comprehensive Cancer CenterChicagoIllinois60637-
Hinsdale Hematology Oncology Associates IncorporatedHinsdaleIllinois60521-
Sudarshan K Sharma MD Limted-Gynecologic OncologyHinsdaleIllinois60521-
University of Iowa/Holden Comprehensive Cancer CenterIowa CityIowa52242-
Massachusetts General Hospital Cancer CenterBostonMassachusetts02114-
University of Massachusetts Medical SchoolWorcesterMassachusetts01655-
University of Massachusetts Memorial Health CareWorcesterMassachusetts01605-
University of Minnesota/Masonic Cancer CenterMinneapolisMinnesota55455-
University of Mississippi Medical CenterJacksonMississippi39216-
Nebraska Methodist HospitalOmahaNebraska68114-
Memorial Sloan-Kettering Cancer CenterNew YorkNew York10065-
Carolinas Medical Center/Levine Cancer InstituteCharlotteNorth Carolina28203-
Duke University Medical CenterDurhamNorth Carolina27710-
Case Western Reserve UniversityClevelandOhio44106-
Cleveland Clinic Cancer Center/Fairview HospitalClevelandOhio44111-
Cleveland Clinic FoundationClevelandOhio44195-
MetroHealth Medical CenterClevelandOhio44109-
Ohio State University Comprehensive Cancer CenterColumbusOhio43210-
Riverside Methodist HospitalColumbusOhio43214-
Miami Valley HospitalDaytonOhio45409-
Hillcrest Hospital Cancer CenterMayfield HeightsOhio44124-
Lake University Ireland Cancer CenterMentorOhio44060-
University of Oklahoma Health Sciences CenterOklahoma CityOklahoma73104-
Oklahoma Cancer Specialists and Research Institute-TulsaTulsaOklahoma74146-
Abington Memorial HospitalAbingtonPennsylvania19001-
Fox Chase Cancer CenterPhiladelphiaPennsylvania19111-
Parkland Memorial HospitalDallasTexas75235-
UT Southwestern/Simmons Cancer Center-DallasDallasTexas75390-
M D Anderson Cancer CenterHoustonTexas77030-

Find similar trials in Los Angeles, CA

By research site
Los Angeles County-USC Medical Center· Los Angeles, CAUSC / Norris Comprehensive Cancer Center· Los Angeles, CAUniversity of Colorado Hospital· Aurora, COHartford Hospital· Hartford, CTThe Hospital of Central Connecticut· New Britain, CTNortheast Georgia Medical Center-Gainesville· Gainesville, GA

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