Bevacizumab Plus Ixabepilone to Treat Patients With Advanced Kidney Cancer

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Cancer Institute (NCI)
Study ID
NCT00923130
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 99 Years
Healthy Volunteers
Not accepted

Interventions

  • Bevacizumab — DRUG
    Bevacizumab will be administered intravenously every 3 weeks on an outpatient basis with the exception of admissions for the purpose of facilitating research studies. The dose of bevacizumab to be given is 15 mg/kg.
  • Ixabepilone — DRUG
    Ixabepilone will be given on days 1, 2, 3, 4, and 5 of each three week cycle as a one hour intravenous infusion. The dose will be 6 mg/m(2)/day on five successive days.

Study Details

Background: * Substantial preclinical antitumor synergy supports the exploration of the combination of antiangiogenic compounds (including sunitinib and bevacizumab) plus ixabepilone. In Vivo, synergistic activity between ixabepilone and bevacizumab has been demonstrated using the 151-B human renal carcinoma xenograft model and this synergy compares favorably with other antiangiogenic inhibitors (i.e. sunitinib). * Combination therapies of bevacizumab with chemotherapy demonstrated improved benefit compared with single-agent cytotoxics in multiple animal models and in humans. * Clinical activity of both compounds used as single agents has been demonstrated in a broad spectrum of solid tumors. Bevacizumab and ixabepilone, when used as a single agent, have demonstrated substantial activity in renal cell carcinoma. * Phase II studies with bevacizumab and ixabepilone suggest the absence of overlapping toxicities. * Development of a well-tolerated and active bevacizumab/ixabepilone combination has the potential to further improve the treatment of metastatic renal cell carcinoma (mRCC), and could represent a second-line option after sunitinib or sorafenib are no longer of benefit or are intolerable. Primary Objectives: * Determine the objective response rate of the combination of ixabepilone and bevacizumab in patients with relapsed or refractory mRCC. * Determine progression-free survival. * Characterize the toxicity of the combination of ixabepilone and bevacizumab in patients with mRCC. * Determine changes in biomarkers and evaluate correlation with clinical outcomes. Eligibility: * Pathologic confirmation of renal cell carcinoma (clear cell histology) by the Laboratory of Pathology, National Cancer Institute (NCI), or the Medical University of South Carolina. * Presence of metastatic renal carcinoma, after progression or intolerance to Vascular endothelial growth factor receptor (VEGFR) inhibitors (sunitinib and/or sorafenib). * Adequate organ and bone marrow function. Design: * Multi-center, open labeled phase II study * Following a Simon two-stage optimal design, a maximum of 58 patients with metastatic RCC will be accrued. * Ixabepilone will be administered daily as a one hour infusion on five successive days (daily x 5), every three weeks (one cycle equals 3 weeks or 21 days +/- 5 days). Following cycle 6, cycles will be spread out to 4 weeks or 28 days +/- 5 days. The starting dose will be a daily dose of 6 mg/m(2)/day, for a total per cycle dose of 30 mg/m(2). * In addition, 15 mg/kg bevacizumab will be administered intravenously on day 1 of each cycle. The first infusion of bevacizumab will be 90 minutes in duration, the second 60 minutes in duration, and in all subsequent cycles bevacizumab will be infused over 30 minutes if prior infusions are well tolerated.

Key Dates

First listed
Jun 18, 2009
Start date
Jan 7, 2009
Status verified
Mar 2018
Primary completion
Mar 1, 2016
Completion
Jun 30, 2016

Study Design

Enrollment
30 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Bevacizumab with Ixabepilone
    Bevacizumab 15mg/kg every 3 weeks Ixabepilone given on days 1,2,3,4 and 5 of each three week cycle at a dose of 6mg/m(2)/day

Primary Outcome Measure

Progression-free Survival [ Time Frame: up to 44 months ]

Locations (2)

FacilityCityStateZIPSite coordinators
National Institutes of Health Clinical Center, 9000 Rockville PikeBethesdaMaryland20892-
University of South CarolinaCharlestonSouth Carolina29425-

Find similar trials in Bethesda, MD

By condition
Kidney cancer
By specialty
OncologyUrology
By research site
National Institutes of Health Clinical Center, 9000 Rockville Pike· Bethesda, MDUniversity of South Carolina· Charleston, SC

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