AZD6244 (Selumetinib) in Treating Patients With Multiple Myeloma

Part of paid clinical trials in Tampa, Florida.

Sponsor
National Cancer Institute (NCI)
Study ID
NCT01085214
Phase
PHASE2
Status
Completed

Conditions

  • Recurrent Plasma Cell Myeloma
  • Refractory Plasma Cell Myeloma

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Laboratory Biomarker Analysis — OTHER
    Correlative studies
  • Selumetinib — DRUG
    AZD6244 (Selumetinib), 75 mg was administered orally, twice a day, continuously for 28-day cycles

Study Details

This phase II trial studies how well selumetinib works in treating patients with multiple myeloma, a type of cancer in which a specific protein is over active. Selumetinib may stop the growth of cancer cells by blocking this protein.

Key Dates

Start date
Mar 31, 2010
Status verified
May 2015
Primary completion
Mar 31, 2012
Completion
Mar 31, 2012

Study Design

Enrollment
37 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: AZD6244 (Selumetinib) Treatment
    Participants receive AZD6244 (Selumetinib) orally (PO) twice a day (BID) on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Primary Outcome Measure

Overall Response Rate [ Time Frame: Up to 2 years ]

Locations (9)

FacilityCityStateZIPSite coordinators
Moffitt Cancer CenterTampaFlorida33612-
Emory University/Winship Cancer InstituteAtlantaGeorgia30322-
University of Maryland/Greenebaum Cancer CenterBaltimoreMaryland21201-
Mark O Hatfield-Warren Grant Magnuson Clinical CenterBethesdaMaryland20892-
National Institutes of HealthBethesdaMaryland20892-
Billings Clinic Cancer CenterBillingsMontana59107-
University of North Carolina at Chapel HillChapel HillNorth Carolina27599-
Vanderbilt University/Ingram Cancer CenterNashvilleTennessee37232-
Virginia Commonwealth University/Massey Cancer CenterRichmondVirginia23298-

Find similar trials in Tampa, FL

By research site
Moffitt Cancer Center· Tampa, FLEmory University/Winship Cancer Institute· Atlanta, GAUniversity of Maryland/Greenebaum Cancer Center· Baltimore, MDMark O Hatfield-Warren Grant Magnuson Clinical Center· Bethesda, MDNational Institutes of Health· Bethesda, MDBillings Clinic Cancer Center· Billings, MT

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