Evaluation of EGFR TKI Resistance Mechanism Using Plasma DNA Analysis

Sponsor
Samsung Medical Center
Study ID
NCT01776684
Status
Unknown

Conditions

  • EGFR Mutation Positive Non-small Cell Lung Cancer

Eligibility Criteria

Sex
ALL
Age
20 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

To detect resistance gene from serially collected plasma DNA in non-small cell lung cancer harbouring EGFR activating mutation who are being treated with EGFR TKIs by using castPCR method.

Key Dates

First listed
Jan 28, 2013
Start date
Jun 30, 2012
Status verified
Jan 2013
Primary completion
May 31, 2014
Completion
May 31, 2015

Study Design

Enrollment
200 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: EGFR positive arm
    Patients with NSCLC harboring activating EGFR mutation (deletion in exon 19, L858R mutation in exon 21)

Primary Outcome Measure

detection of resistant gene [ Time Frame: 24 months ]

Central Contacts

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