Cabozantinib (XL184) in Patients With Relapsed or Refractory Myeloma

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT01866293
Phase
PHASE1/PHASE2
Status
Completed

Conditions

  • Relapsed or Refractory Multiple Myeloma

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

This study is an open label phase I/II trial to investigate the safety and efficacy of Cabozantinib for patients with relapsed or refractory myeloma.

Key Dates

Start date
May 28, 2013
Status verified
Feb 2017
Primary completion
Aug 18, 2016
Completion
Aug 18, 2016

Study Design

Enrollment
11 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Cabozantinib (XL184)
    Eligible patients will receive cabozantinib as a tablet, orally daily. One cycle is defined as 28 days. Myeloma response will be assessed by IMWG criteria after each cycle. The DLT evaluation period will be six weeks. This trial will be a standard 3 by 3 dose escalation design, where three daily dose levels (20mg, 40mg, and 60mg) will be investigated.

Primary Outcome Measure

Maximally Tolerated Dose [ Time Frame: 1 year ]

Locations (5)

FacilityCityStateZIPSite coordinators
Memoral Sloan Kettering Cancer CenterBasking RidgeNew Jersey--
Memorial Sloan Kettering Cancer Center @ SuffolkCommackNew York11725-
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065-
Memorial Sloan Kettering Cancer Center at Mercy Medical CenterRockville CentreNew York11570-
Memorial Sloan Kettering Cancer Center at Phelps Memorial Hospital CenterSleepy HollowNew York10591-

Find similar trials in Basking Ridge, NJ

By research site
Memoral Sloan Kettering Cancer Center· Basking Ridge, NJMemorial Sloan Kettering Cancer Center @ Suffolk· Commack, NYMemorial Sloan Kettering Cancer Center· New York, NYMemorial Sloan Kettering Cancer Center at Mercy Medical Center· Rockville Centre, NYMemorial Sloan Kettering Cancer Center at Phelps Memorial Hospital Center· Sleepy Hollow, NY

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