Liraglutide Efficacy on Glucocorticoid Induced Hyperglycemia in Patients High Risk for Diabetes

Sponsor
Rabin Medical Center
Study ID
NCT02016846
Phase
PHASE3
Status
Unknown

Conditions

  • Glucocorticoid Induced Hyperglycemia

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

Glucocorticoids therapy exposes the patient to an increased risk for diabetes morbidity. However, there is no proven preventive therapy. GLP-1-RA has shown to improve glucose metabolism in healthy volunteers treated with glucocorticoids. We assume that GLP-1-RA will improve glucose metabolism in patients with high risk for diabetes morbidity, treated with glucocorticoids.

Key Dates

Start date
Jan 31, 2014
Status verified
Dec 2013
Primary completion
Jan 31, 2015

Study Design

Enrollment
36 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Placebo Comparator: Placebo
  • Active Comparator: Intervention
    Liraglutide, tapered from 0.6 mg/day to 1.8 mg/day.

Primary Outcome Measure

Glucose levels 2 hours after 75 gr OGTT [ Time Frame: 6 weeks ]

Central Contacts