Pilot Study of Ranibizumab With and Without Ketorolac Eyedrops for Exudative Age-related Macular Degeneration
- Sponsor
- Università degli Studi di Brescia
- Study ID
- NCT02060604
- Phase
- PHASE4
- Status
- Completed
Conditions
- Wet Macular Degeneration
Eligibility Criteria
- Sex
- ALL
- Age
- 40 Years - N/A
- Healthy Volunteers
- Not accepted
Interventions
- Ketorolac + Ranibizumab — DRUG3 monthly ranibizumab, then as needed Ketorolac TID
- Ranibizumab — DRUG3 monthly ranibizumab, then as needed
Study Details
The addition of an anti-inflammatory agent could be a valid option for controlling choroidal neovascularization, as simply inhibiting VEGF addresses neither the multifactorial pathogenesis of choroidal neovascularization nor the underlying cause of VEGF production.
Key Dates
- First listed
- Feb 12, 2014
- Start date
- Dec 31, 2012
- Status verified
- Feb 2014
- Primary completion
- Jan 31, 2014
- Completion
- Jan 31, 2014
Study Design
- Enrollment
- 60 participants (actual)
- Allocation
- RANDOMIZED
- Intervention model
- PARALLEL
- Primary purpose
- TREATMENT
Arms
- Experimental: Ketorolac + Ranibizumab3 monthly ranibizumab, then as needed plus ketorolac eyedrops TID
- Active Comparator: Ranibizumab Alone3 monthly ranibizumab, then as needed
Primary Outcome Measure
mean change in study eye visual acuity as measured by the best-corrected ETDRS letter score [ Time Frame: 12 months ]
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