Comparing Injection Frequency Between Aflibercept and Ranibizumab in Patients With CRVO With a Treat& Extend Regimen

Sponsor
Anders Kvanta
Study ID
NCT02274259
Phase
PHASE4
Status
Completed

Conditions

  • Central Retinal Vein Occlusion

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Aflibercept — DRUG
    Aflibercept injection is given at every visit. Time to next treatment according to presence of macular edema
  • Ranibizumab — DRUG
    Ranibizumab injection is given at every visit. Time to next treatment according to presence of macular edema

Study Details

Comparing ranibizumab and aflibercept in a treat and extend algorithm evaluating the number of needed injections over a 18 month period in patients with newly diagnosed CRVO.

Key Dates

Start date
Oct 31, 2014
Status verified
Dec 2020
Primary completion
Jun 30, 2015
Completion
Dec 31, 2016

Study Design

Enrollment
40 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Aflibercept
    Aflibercept injection is given at every visit. Time to next treatment according to presence of macular edema
  • Active Comparator: Ranibizumab
    Ranibizumab injection is given at every visit. Time to next treatment according to presence of macular edema

Primary Outcome Measure

The number of needed injections over a 18 month period comparing ranibizumab and aflibercept. [ Time Frame: 18 months ]