An Investigational Immunotherapy Study of BMS-986299 Alone and in Combination With Nivolumab and Ipilimumab in Participants With Solid Cancers That Have Spread or Cannot be Removed

Part of paid clinical trials in La Jolla, California.

Sponsor
Bristol-Myers Squibb
Study ID
NCT03444753
Phase
PHASE1
Status
Terminated

Conditions

  • Advanced Cancer

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • BMS-986299 — DRUG
    Specified dose on specified day
  • Nivolumab — BIOLOGICAL
    Specified dose on specified day
  • Ipilimumab — BIOLOGICAL
    Specified dose on specified day

Study Details

The purpose of this study is to determine whether BMS-986299 both by itself and in combination with Nivolumab and Ipilimumab is safe and tolerable in the treatment of advanced solid tumors. In addition, the ability of study drugs to stimulate an immune response against cancer will be investigated.

Key Dates

Start date
Apr 5, 2018
Status verified
May 2022
Primary completion
Feb 14, 2022
Completion
Feb 14, 2022

Study Design

Enrollment
82 participants (actual)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Arm A
    BMS-986299
  • Experimental: Arm B
    BMS-986299 in combination with nivolumab and ipilimumab

Primary Outcome Measure

Incidence of dose-limiting toxicities (DLTs) [ Time Frame: Up to 28 days ]

Locations (9)

FacilityCityStateZIPSite coordinators
Local Institution - 0003La JollaCalifornia92093-0698-
Local InstitutionOrangeCalifornia92868-
University of California Davis Medical CenterSacramentoCalifornia95817-
Local InstitutionNew HavenConnecticut06520-
Local InstitutionDetroitMichigan48202-
Washington UniversitySt LouisMissouri63110-
Local InstitutionPortlandOregon97239-
Local InstitutionPittsburghPennsylvania15232-1305-
MD Anderson Cancer CenterHoustonTexas77030-

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