Fibro-inflammatory Progression From Acute to Chronic Pancreatitis

Sponsor
Copenhagen University Hospital, Hvidovre
Study ID
NCT03853447
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • Diagnostic imaging — DIAGNOSTIC_TEST
    MRI assessments including magnetic resonance cholangiopancreatography (MRCP) and diffusion weighted imaging (DWI) combined with gold standard EUS

Study Details

Observational prospective study evaluating the developement of chronic pancreatitis based on imaging modalities as well as biochemical markers of inflammation, fibrosis and oxidative stress.

Key Dates

First listed
Feb 25, 2019
Start date
Feb 14, 2019
Status verified
Apr 2020
Primary completion
Jan 1, 2040
Completion
Jan 1, 2041

Study Design

Enrollment
150 participants (estimated)

Arms

  • Arm: Diagnostic imaging
    The progression of fibrosis will be assessed based on diagnostic imaging of thre subgroups including Patients with chronic pancreatitis (CP; N=50) of any aetiology, except gallstones, based on MANNHEIM. Patients with their first attack of acute pancreatitis (AP; N=50) of any aetiology except gallstones using the revised Atlanta criteria for AP. Patients with recurrent AP (RAP; N=50) except gallstones, defined as two or more cases of AP as diagnosed by the revised Atlanta Criteria.

Primary Outcome Measure

Fibrosis progression on endoscopic ultrasound (EUS) or magnetic resonance imaging (MRI) [ Time Frame: 15 years ]

Central Contacts

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