A Safety and Preliminary Efficacy Study of CC-99282, Alone and in Combination With Anti-lymphoma Agents in Participants With Relapsed or Refractory Non-Hodgkin Lymphomas (R/R NHL)

Part of paid clinical trials in Scottsdale, Arizona.

Sponsor
Celgene
Study ID
NCT03930953
Phase
PHASE1/PHASE2
Status
Active Not Recruiting

Conditions

  • Lymphoma, Non-Hodgkin

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • CC-99282 — DRUG
    Specified dose on specified days
  • Rituximab — DRUG
    Specified dose on specified days
  • Obinutuzumab — DRUG
    Specified dose on specified days
  • Tafasitamab — DRUG
    Specified dose on specified days
  • Valemetostat — DRUG
    Specified dose on specified days

Study Details

The purpose of this study is to evaluate the safety, tolerability, and preliminary efficacy of CC-99282 alone and in combination with anti-lymphoma agents in participants with relapsed or refractory non-Hodgkin's lymphomas.

Key Dates

First listed
Apr 29, 2019
Start date
May 20, 2019
Status verified
Feb 2026
Primary completion
Apr 7, 2027
Completion
Feb 9, 2028

Study Design

Enrollment
438 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Part A: Dose Escalation
  • Experimental: Part B: Dose Expansion

Primary Outcome Measure

Number of participants with Eastern Cooperative Oncology Group (ECOG) performance status abnormalities [ Time Frame: From the time of consent at screening until 28 days after the subject discontinued study treatment (up to 4 years) ]

Locations (8)

FacilityCityStateZIPSite coordinators
Local Institution - 109ScottsdaleArizona85259-
Local Institution - 111JacksonvilleFlorida32224-
Local Institution - 102TampaFlorida32207-
Local Institution - 108Overland ParkKansas66210-
Local Institution - 107RochesterMinnesota55905-
Local Institution - 104St LouisMissouri63110-
Local Institution - 103HackensackNew Jersey07601-
Local Institution - 101HoustonTexas77030-

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