Investigating Pathological Mechanisms in Non-alcoholic Fatty Liver Disease

Sponsor
Queen Mary University of London
Study ID
NCT04141592
Status
Recruiting
Apply to this trial

Conditions

  • Non-Alcoholic Fatty Liver Disease

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Bariatric Surgery — PROCEDURE
    Already clinically indicated surgical procedures

Study Details

To identify key characteristics of the tissue resident and peripherally circulating immune-phenotype in addition to blood markers, metabolic profile, faecal and oral microbiota in non-alcoholic fatty liver disease

Key Dates

First listed
Oct 28, 2019
Start date
Mar 5, 2019
Status verified
Jun 2026
Primary completion
Jul 31, 2026
Completion
Jul 31, 2026

Study Design

Enrollment
153 participants (estimated)

Arms

  • Arm: Healthy Control
    non-obese individuals without fatty liver disease
  • Arm: Obese wihtout non-alcoholic steatohepatitis
    Body mass index greater than 30 without liver histological evidence of non-alcoholic fatty liver disease
  • Arm: Obese Non-alcoholic steatohepatitis
    Body mass index greater than 30 with liver histological evidence of non-alcoholic fatty liver disease

Primary Outcome Measure

Impact of weight loss surgery upon Non-alcoholic steatohepatitis [ Time Frame: Two years ]

Central Contacts

Related Studies