Cabozantinib With Radiation Therapy for the Treatment of Sarcomas of the Extremities

Part of paid clinical trials in Seattle, Washington.

Sponsor
University of Washington
Study ID
NCT04220229
Phase
PHASE1/PHASE2
Status
Terminated

Conditions

  • Sarcoma of the Extremity
  • Stage I Soft Tissue Sarcoma of the Trunk and Extremities
  • Stage IA Soft Tissue Sarcoma of the Trunk and Extremities
  • Stage IB Soft Tissue Sarcoma of the Trunk and Extremities
  • Stage II Soft Tissue Sarcoma of the Trunk and Extremities

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Cabozantinib S-malate — DRUG
    Given PO
  • Radiation Therapy — RADIATION
    Undergo standard of care radiation therapy

Study Details

This phase I/II trial studies the side effects and best dose of cabozantinib when given with radiation therapy and how well it works in treating patients with sarcoma of the extremities. Cabozantinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving cabozantinib with radiation therapy may make the tumors smaller and reduce the amount of normal tissue that needs to be removed.

Key Dates

Start date
Jun 1, 2020
Status verified
Jun 2025
Primary completion
Apr 5, 2024
Completion
Oct 31, 2024

Study Design

Enrollment
6 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment (cabozantinib S-malate, radiation therapy)
    Patients receive cabozantinib S-malate PO QD on days 1-21. Cycles repeat every 21 days until the completion of radiation therapy in the absence of disease progression or unacceptable toxicity. Beginning cycle 1 day 8, patients also undergo standard of care radiation therapy for 5-6 weeks.

Primary Outcome Measure

Recommended Phase 2 Dose of Cabozantinib S-malate (Cabozantinib) (Phase I) [ Time Frame: Up to 21 days ]

Locations (1)

FacilityCityStateZIPSite coordinators
Fred Hutch/University of Washington Cancer ConsortiumSeattleWashington98109-

Find similar trials in Seattle, WA

By research site
Fred Hutch/University of Washington Cancer Consortium· Seattle, WA

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