Effects of Drinking Beetroot Juice on Exercise Performance in Patients With Fibrotic Interstitial Lung Disease

Sponsor
University of British Columbia
Study ID
NCT04299945
Status
Recruiting
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Conditions

  • Interstitial Lung Disease

Eligibility Criteria

Sex
ALL
Age
19 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • concentrated beetroot juice (400mg of nitrate per serving) — DIETARY_SUPPLEMENT
    Dietary nitrate supplementation includes consumption of two beverages daily for 7 consecutive days.
  • concentrated beetroot juice (trace amounts of nitrate per serving) — DIETARY_SUPPLEMENT
    Dietary placebo supplementation includes consumption of two beverages daily for 7 consecutive days.

Study Details

Exercise training as part of a structured pulmonary rehabilitation program is a key factor in improving quality of life and symptoms in people with interstitial lung disease (ILD). Optimal methods of exercise training are yet to be explored in ILD. Drinking beetroot juice, which is rich in nitrate, has been shown to improve exercise performance in a variety of groups, but its effects in ILD have not been tested. The purpose of this study is to determine if drinking nitrate-rich beetroot juice can improve exercise performance compared to drinking nitrate-free beetroot juice in people with ILD.

Key Dates

First listed
Mar 9, 2020
Start date
Aug 7, 2024
Status verified
May 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
15 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE

Arms

  • Experimental: Dietary nitrate supplementation
    The dietary nitrate supplement will be a concentrated, nitrate-rich beetroot juice (70 ml providing ∼400mg nitrate per serving)
  • Placebo Comparator: Placebo
    The placebo will be a concentrated, nitrate-depleted beetroot juice (70 ml with trace amounts of nitrate)

Primary Outcome Measure

Difference in submaximal cycle exercise endurance time following dietary nitrate supplementation compared to placebo supplementation. [ Time Frame: 1 Week ]

Central Contacts

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