Hantavirus Registry - HantaReg

Sponsor
University of Cologne
Study ID
NCT04323904
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Not accepted

Interventions

  • Retrospective data collection — OTHER
    Retrospective data collection from patients with hantavirus infection and matching control group patients.

Study Details

Hantavirus disease are zoonotic infections and remain a clinical challenge with globally increasing incidence and multiple serious outbreak situations in Europe within the last years. Hantavirus disease encompasses two clinical syndromes, hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS) caused by Old World and New World hantaviruses, respectively. Depending on the causative Old World hantavirus species, clinical course of HFRS can vary from mild to moderate to severe. At present, there is no specific therapy available for hantavirus disease. As the clinical course of hantavirus disease is dependent on the causing viral pathogen and as there worrisome hints that clinical course HFRS and HCPS overlap, further studies with regard to the disease course are mandatory. Furthermore, the examination of attributable mortality and costs of hantavirus disease will need to be studied on a multinational basis and therefore HantaReg will particularly use a matched case control design.

Key Dates

Start date
Mar 4, 2020
Status verified
Dec 2025
Primary completion
Mar 31, 2030
Completion
Dec 31, 2030

Study Design

Enrollment
200 participants (estimated)

Arms

  • Arm: Hantavirus Group
    Patients with cultural, serological, molecular evidence of hantavirus infection
  • Arm: Control group
    Controls will be included at the same hospitals that conduced cases based on matching of demographics, underlying diseases and duration of hospitalization (i.e. one control per case, both in the same hospital)

Primary Outcome Measure

Incidence [ Time Frame: up to 100 weeks ]

Central Contacts