UCSD Image-Guided Cognitive-Sparing Radiosurgery for Intracranial Lesions

Part of paid clinical trials in San Diego, California.

Sponsor
Jona Hattangadi-Gluth
Study ID
NCT04343157
Phase
PHASE2
Status
Recruiting
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Conditions

  • Arteriovenous Malformations, Cerebral
  • Brain Metastases, Adult
  • Cancer
  • Meningioma of Brain
  • Neurocognitive Function

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Cognitive Sparing Brain Stereotactic Radiosurgery (SRS) — RADIATION
    In this proposal, the investigators introduce advanced diffusion and volumetric imaging techniques along with innovative, automated image parcellation methods to identify critical brain regions, incorporate into cognitive-sparing SRS, and analyze biomarkers of radiation response. This work will advance the investigators' understanding of neurocognitive changes after brain SRS and help create interventions that preserve cognitive-function during SRS for intracranial lesions

Study Details

In this proposal, the investigators introduce advanced diffusion and volumetric imaging techniques along with innovative, automated image parcellation methods to identify critical brain regions, incorporate into cognitive-sparing SRS for intracranial lesions, and analyze biomarkers of radiation response. This work will advance the investigators' understanding of neurocognitive changes after brain SRS and help create interventions that preserve cognitive-function in patients with intracranial lesions.

Key Dates

First listed
Apr 13, 2020
Start date
May 1, 2019
Status verified
Sep 2026
Primary completion
Dec 31, 2028
Completion
Dec 31, 2028

Study Design

Enrollment
90 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Image-guided cognitive sparing brain SRS
    This is a single arm phase II study where enrolled subjects will receive intracranial SRS will performed identically to standard of care, except for implementing additional imaging techniques and software for additional regional avoidance for cognitive sparing (specifically sparing white matter and the bilateral hippocampus)

Primary Outcome Measure

Change in Verbal Memory from baseline to 3 months after SRS [ Time Frame: Change from Baseline (pre-treatment) to 3 months post treatment ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Moores Cancer CenterSan DiegoCalifornia92037
Sheila Medina
[email protected]
858-822-6575
Jona Hattangadi-Gluth, MD (PRINCIPAL_INVESTIGATOR)

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By research site
Moores Cancer Center· San Diego, CA

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