ASL in Brain Metastasis MRI Following Gamma Knife Treatment

Sponsor
Assistance Publique - Hôpitaux de Paris
Study ID
NCT04833335
Status
Recruiting
Apply to this trial

Conditions

  • Brain Metastases

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • MRI perfusion sequence — OTHER
    Quantitative analysis

Study Details

Arterial spin labeling (ASL) is a non-invasive MRI technique that could help the radiologists to distinguish brain metastasis progression versus radionecrosis following gamma-knife treatment. The primary target of the study is to establish the diagnostic performances (specificity, sensitivity) of quantitative measures of ASL in brain metastases suspected of progression/radionecrosis after GK treatment

Key Dates

First listed
Apr 6, 2021
Start date
Jan 24, 2023
Status verified
Aug 2025
Primary completion
Sep 24, 2028
Completion
Sep 24, 2028

Study Design

Enrollment
60 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: Adults with brain metastases treated with Gamma Knife whose lesions suggest tumor recurrence versus
    Inclusion visit, 1 month later, 6 month later

Primary Outcome Measure

Diagnostic performance of ASL quantitative analysis in brain metastasis following GK treatment : tumor perfusion with quantitative measurement (one value) of RCBF (relative cerebral blood flow) on the ASL sequence [ Time Frame: Evolution between Baseline MRI, 1 and 6 month follow up MRI ]

Central Contacts

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